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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Indonesia Prosiding Seminar Nasional Unimus
Ghani Nurfiana Fadma Sari
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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AKTIVITAS ANTIBAKTERI DAN BIOAUTOGRAFI EKSTRAK DAUN RAMBUSA (Passiflora foetida L) TERHADAP Pseudomonas aeruginosa-Klebsiella pneumoniae Ghani Nurfiana Fadma Sari; Ismi Puspitasari
Media Farmasi: Jurnal Ilmu Farmasi Vol 18, No 2: September 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.676 KB) | DOI: 10.12928/mf.v18i2.21537

Abstract

Daun rambusa (Passiflora foetida L.) mempunyai khasiat sebagai antioksidan, antidiabetes dan antikolesterol, akan tetapi masih belum banyak informasi ilmiah tentang potensi daun rambusa sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui golongan senyawa aktif dan aktivitas antibakteri dari ekstrak daun rambusa secara difusi. Daun rambusa diekstraksi secara maserasi menggunakan etanol 96%. Ekstrak yang diperoleh kemudian diidentifikasi kandungan golongan senyawa aktif menggunakan KLT-Bioautografi dan diuji aktivitas antibakteri dengan konsentrasi 20%, 40% dan 60% menggunakan metode difusi agar. Kontrol positif yang digunakan adalah kloramfenikol 0,1% dan kontrol negatif menggunakan DMSO 5%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun rambusa efektif menghambat aktivitas bakteri Klebsiella pneumonia dan Pseudomonas aeruginosa. Konsentrasi ekstrak yang paling besar zona hambatnya yaitu konsentrasi 60% yang dikategorikan kuat. Pengujian aktivitas antibakteri dilakukan dengan metode bioautografi kontak hasilnya menunjukkan terdapat bercak pada kromatogram KLT yang menghasilkan zona hambat. Karakterisasi bercak dilakukan dengan penampak bercak AlCl3 dan diduga bahwa bercak tersebut flavonoid. 
Aktivitas Antibakteri Ekstrak Dan Fraksi Daun Manggis (Garcinia Mangostana) Terhadap Staphylococcus aureus Taufik Turahman; Ghani Nurfiana Fadma Sari
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (708.045 KB) | DOI: 10.31001/jfi.v15i2.453

Abstract

Infectious diseases are still one of the important public health problems to be considered especially in developing countries. Mangosteen leaf (Garcinia mangostana L.) is a well-known plant that is useful as an antioxidant, antibacterial and anticancer. This study aims to determine the chemical content and antibacterial activity of ethanol extract, n-hexane fraction, ethyl acetate and water of mangosteen leaves (Garcinia mangostana L.) on Staphylococcus aureus by diffusion and dilution Mangosteen leaves were extracted by maceration using 96% ethanol then continued by fractionation using a liquid-liquid extraction method. Antibacterial activity was then tested using disc diffusion method with a concentration of 12.5%, 25% and 50%. Positive control used was ciprofloxacin 5μg / disk and negative control of 5% Tween 80. Dilution test was carried out on the most active extract by looking at the MIC and MBC. Identification of compound groups can be done using Thin Layer Chromatography method. The results of antibacterial activity testing showed that the diameter of the largest inhibitory zone in Staphylococcus aureus bacteria was found in the water fraction of mangosteen leaves at 50% concentration with inhibition zone diameter (10 mm). The results of the minimum MIC inhibitory level and the minimum suicide rate of MBC at a concentration of 12.5%. The TLC test results showed that in the extracts and fractions of mangosteen leaves contained flavonoids, saponins and steroids
Aktivitas Antibakteri Ekstrak Dan Fraksi Herba Kemangi (Ocimum Sanctum L) Terhadap Staphylococcus Aureus Dan Pseudomonas Aeruginosa Taufik Turahman; Ghani Nurfiana Fadma Sari
Jurnal Farmasi Indonesia Vol 16 No 2 (2019): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.882 KB) | DOI: 10.31001/jfi.v16i2.596

Abstract

Infectious disease is still one of the public health problems, especially in developing countries. Etiology is generally caused by Staphylococcus aureus and Pseudomonas aeruginosa. Basil (Ocimum sanctum L) is a plant known as lalapan which has antioxidant, anticancer and antimicrobial properties but there is not much scientific information as an antibacterial. This study aims to determine the chemical content and antibacterial activity of ethanol extract, n-hexane fraction, ethyl acetate and basil herb water on the growth of Staphylococcus aureus and Pseudomonas aeruginosa by diffusion and dilution. Herbs are macerated using 96% ethanol. The extract obtained was then suspended with water and then fractionated with n-hexane and ethyl acetate. Basil extract and the fractions obtained were then tested for antibacterial activity at concentrations of 12.5%, 25% and 50% using the diffusion method. The MIC and MBC of the most active fractions can be known using dilution tests with concentrations of 0.78, 1.56, 3.125, 6.25%, 12.5%, 25% and 50%. Ciprofloxacin positive control 5μg/15μl and negative control using sterile 80% 5% tween. Identification of groups of compounds is done by the test tube method. Antibacterial activity test results showed that the zone of inhibition zone in gram-negative bacteria in general tends to be larger than gram-positive bacteria. The largest inhibition zone diameter in the bacterium Pseudomonas aeruginosa in the ethyl acetate fraction basil concentration 50% with a diameter of inhibition zone (10 mm), in the Staphylococcus aureus bacteria found in the ethyl acetate fraction at a concentration of 50% has inhibitory power of (8.6 mm). The results of the identification of the chemical content showed that the extract and fraction of basil herbs contain flavonoids, saponins and steroids and tannins Keywords: Antibacterial, Basil (Ocimum sanctum L), Staphylococcus aureus, Pseudomonas aeruginosa
Uji Sitotoksik Ekstrak Etanol Daun Stevia (Stevia Rebaudiana Bertoni) pada Kultur Sel Hela Ghani Nurfiana Fadma Sari; Endang Sri Rejeki
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.875

Abstract

In Indonesia cervical cancer ranks second after breast cancer experienced by women. Stevia is a shrub that is used as a low-calorie sweetener. Stevia also has bioactive compounds such as steviosida, alkaloids, tanin, steroid and flavonoid which are useful as a treatment. Stevia leaf research as an anticancer has not been done much. Therefore, research on the cytotoxic effects of stevia leaves on HeLa cells. The purpose of this study was to determine the IC50 value of stevia leaves on HeLa cells. Stevia leaf extraction was carried out by maceration method using 96% ethanol solvent. The ethanol extract of stevia leaves was tested for its effect on HeLa cells using the MTT method with a concentration series of 500; 250; 125; 62.5; 31.25; 15,625 µg / mL. Cisplastin (Kalbe) is used as a positive control and cell control as a negative control. The results of testing the cytotoxic activity of stevia leaf ethanol extract on HeLa cells showed an IC50 value of 512.94 ± 1.62 µg / ml and IC50 value of Cisplatin 16.16 ± 1.75 µg / ml. This shows that ethanol extract of stevia leaves can be used as a cancer chemo preventive agent that acts to prevent the development of cancer cells
Pengaruh Corona Virus Disease terhadap Penjualan Produk Suplemen Kesehatan Khotimatul Khusna; Rita Septiana; Ghani Nurfiana Fadma Sari; Isma Rosida
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.937

Abstract

Corona Virus Disease-19 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on March 11, 2020, previously on March 2, 2020 Indonesia has reported 2 confirmed cases of COVID-19. Immunomodulators that can increase the body's resistance to the COVID-19 virus by stimulating the immune system. The purpose of this study was to determine the effect of COVID-19 on the sale of health supplement products in a pharmacy in Surakarta.This research is an analytical observational research. Data was collected from sales records at pharmacies in the 3 months before the COVID-19 pandemic and 3 months at the beginning of the COVID-19 pandemic. Data analysis using statistical tests.Sales of health supplement products for 6 months were 17843 pcs. There were 4773 health supplement products sold before the pandemic, while 13070 pcs were sold during the pandemic. The results of the normality test showed that the data were not normally distributed. The Wilcoxon test results show that the significant value is 0.028 (<0.05), meaning that there is a difference in sales before and after the determination of the pandemic. The conclusion of this study is that COVID-19 has an effect on the sale of health supplement products in a pharmacy in Surakarta.
Aktivitas Antioksidan Ekstrak Dan Fraksi Herba Ciplukan (Physalis Angulata) Terhadap Dpph (1,1-Difenil-2-Pikrilhidrazil) Ghani Nurfiana Fadma Sari
Prosiding Seminar Nasional Unimus Vol 1 (2018): Hilirisasi & Komersialisasi Hasil Penelitian dan Pengabdian Masyarakat untuk Indonesia
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antioksidan berperan sebagai pelindung tubuh yang berfungsi menangkal radikal bebas. Keseimbangan antara antioksidan dan radikal bebas untuk menjaga fungsi fisiologis tubuh, sehingga asupan dari sumber luardiperlukan untuk membantu tubuh mengatasi tekanan oksidatif. Ciplukan(Physalis Angulata L) secra tradisional telah digunakan secra luas untuk mengatasi berbagai macam penyakit, dan salah satu kegunaannya adalah sebagai antioksidan. Penelitian ini dilaksanakan untuk menentukan jenis dan juga mengukur aktifitas dari ekstrak dan penyaringan dari tanaman herbal. Ciplukan diekstraksi  dengan maserasi ethanol 95%. Ekstrak yang dihasilkan ditambahkan dengan cairan cairan ekstraksi. Test aktifitas antioksidan dialkukan dengan mekanismein vitro menggunakan pengurangan radikal bebas metode DPPH(1-1 difenil-2- fikrihidrasil). Hasilnya menunjukkan bahwa ekstrak tanaman ciplukan dengan penambahan yang mengandung flavonoid, alkaloid,steroid, dan saponin. Actifitas anti oksidan dalam ekstrak etanol, n-penambahan heksan, penambahan etil asetat,dan penambahan air memberikan nilai IC setara 793,97; 623.20;213.34;407.91/mL. penambahan etil asetat memiliki aktifitas terkuat dibandingkan dengan yang lain dengan nilai IC50 mendekati IC50 kurcetin, dengan 3.85/mL sebagai control positif.
Co-Authors Isma Rosida Khotimatul Khusna Puspitasari, Ismi Rita Septiana Taufik Turahman