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Muhammad Mirza Hardiansyah
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Chemistry

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Direct Amidation of ethyl p-methoxycinnamate to Produce N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide Ismiarni Komala; Supandi Supandi; Muhammad Mirza Hardiansyah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (469.902 KB) | DOI: 10.15408/jkv.v4i1.7300

Abstract

Ethyl p-methoxycinnamate (EPMC) (1) is found as a major natural ester in the rhizome of Kaempferia galanga (kencur) and has been known to have various pharmacological activities. The previous study has reported the synthesis of N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide (2) by using microwave-assisted direct amidation of EPMC (1) with diethanolamine. In this research, we attempt to synthesize of 2 by using a conventional direct amidation of EPMC (1) with diethanolamine. The reaction was conducted without adding any coupling reagents or catalyst. Structure of the synthetic product was determined by using analysis of GC-MS, IR, and 1H-NMR spectroscopic data and then compared to the previously reported.DOI:http://dx.doi.org/10.15408/jkv.v4i1.7300
Co-Authors Ismiarni Komala Supandi Supandi