<![CDATA[The purpose of this research is to analyze the effect of Non Performing Financing,Operational Efficiency Ratio, BI Rate and inflation toward the rate of return mudharabah deposits islamic bank industries in Indonesia start from January 2012 until December 2016. This research use quantitative approach. The analysis method used in this research is time series regression using eviews 9.0 program. This research used saturation sampling. Sample that used in this research were taken from Islamic Bank Statistic issued by OJK, while BI Rate and Inflation taken from www.bi.go.id. The result show that Non Performing Financinghas no effect on the rate of return mudharabah deposits, Beban Operasional Pendapatan Operasional has no effect on the rate of return mudharabah deposits. While BI Rate has positive and significant on the rate of return mudharabah deposits, and than variabel inflation has negative and significant on the rate of return mudharabah deposits. 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