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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional
Sugeng Riyanto
Faculty of Pharmacy, Universitas Gadjah Mada
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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EFEK SENYAWA FLAVONOIDS DARI KEMUNING (Murraya paniculata [L.] Jack.) TERHADAP PELEPASAN HISTAMIN DARI KULTUR SEL MAST Agung Endro Nugroho; Sugeng Riyanto; Mohamad Aspollah Sukari; Kazutaka Maeyama
Majalah Obat Tradisional Vol 15, No 1 (2010)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (503.985 KB) | DOI: 10.22146/tradmedj.8066

Abstract

Murraya paniculata [L.] Jack. (Kemuning) is a plant that grows widely in some areas of Indonesia. Studies related to this plant have been widely explored especially isolation of its active compounds. The plant contents several active compounds such as flanovoids. In the study, three flavonoid isolated from M. paniculata were evaluated for their effect on histamine release from mast cells (RBL-2H3 cells). These compounds were 3,3’,4’,5,5’,6,7,8-octamethoxyflavone; 3,3’,4’,5,5’,6,7-heptamethoxyflavone and 3, 3’, 4’, 5, 5’, 7–hexamethoxyflavone. The histamine inducers used in the study were DNP24-BSA dan thapsigargin, inducing the histamine release immunologically and non-immunologically, respectively. In the study, heptamethoxyflavone and hexamethoxyflavone did not influence the histamine release from mast cells significantly. However, octamethoxyflavone could increase the histamine release from RBL-2H3 cells in absence and presence the histamine inducers. The flavanoid could increase the release of histamine up to 50 %. Based on the results, polymethoxy moieties at the structure of flavonoid have a significant role to emerge the histamine-release stimulating effect from mast cells. 
Macroscopy and Microscopy Study of Scopraia dulcis L. Djoko Santosa; Subagus Wahyuono; Sugeng Riyanto; SM Widyastuti
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (395.926 KB) | DOI: 10.22146/mot.31261

Abstract

A morphological diversity analysis of Scoparia dulcis by macroscopy and microscopy has been conducted. The aim of this research is to determine the morphological and anatomical character of S. dulcis which grow in Opak watershed, Special Region of Yogyakarta. Samples were taken from Sleman (Cangkringan, Ngemplak Kalasan, and Prambanan) and Bantul (Imogiri and Pundong) region. Selection of sampling location is based on altitude difference. The samples are the third leaf order from the tip of the stem. They were measured in length and width. Microscopy analysis was performed by observing the number of glandular trichomes, palisade cells in the epidermis and stomata in the upper and lower epidermis. The data obtained were analyzed using principal component analysis (PCA). The results show that based on morphological and anatomical assessment, there were found 3 clusters of S. dulcis, i.e. Cangkringan-Ngemplak-Prambanan, Kalasan, and Imogiri-Pundong cluster.
Antiproliferative Effect of Chloroform Extract of Cangkring Leaves (Erythrina fusca Lour.) and Its Isolates against HeLa Cells Endah Puspitasari; Endah Dwi Setyowati; Binar Asrining Dhiani; Sugeng Riyanto
Indonesian Journal of Cancer Chemoprevention Vol 3, No 1 (2012)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev3iss1pp358-363

Abstract

Cervical cancer is a type of cancer possessing the 3rd highest incidence among women worldwide. Today’s therapies against cancer are still ineffective, thus people are seeking for alternative method. Erythrina fusca Lour. has been used traditionally as anticancer. This experiment is conducted to study the ability of chloroform extract of E. fusca Lour. leaves and its isolates on HeLa cervical cancer cells. The cytotoxicity assay and doubling time assay were done using direct counting method, while the DNA staining assay was done using acrydine orange. The chloroform extract and isolate # 30 showed cytotoxic activity with IC50 of 16 and 5 µg/ml, respectively, while isolate # 2 and isolate # 8 didn’t. The effluent # 30 could not affect HeLa cells growth at the given concentration, but it might promote DNA fragmentation indicating apoptosis induction. The molecular mechanisms underlying these effects still need to be further explored.Keywords: Erythrina fusca Lour., isolate and effluent of chloroform extract, antiproliferative, cervical cancer
Co-Authors Agung Endro Nugroho Binar Asrining Dhiani Djoko Santosa Endah Dwi Setyowati Endah Puspitasari Kazutaka Maeyama Mohamad Aspollah Sukari SM Widyastuti Subagus Wahyuono