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All Journal Majalah Obat Tradisional
Azka M. Rusydan
Master Program, Faculty of Pharmacy, Universitas Gadjah Manda, Yogyakarta
Health Professions Medicine & Pharmacology Public Health

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Journal : Majalah Obat Tradisional

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Modeling and Optimization of Mitragyna speciosa Extraction using Box Behnken Design Azka M. Rusydan; Endang Lukitaningsih; Nanang Fakhrudin
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68610

Abstract

The extraction of kratom (M. speciosa) leaf powder was optimized with preliminary extraction to be further optimized with the Box-Behnken experimental design. The individual and interactive effects of process variables (sample-to-solvent ratio, extraction time, solvent concentration) were assessed. The preliminary extraction results showed that ultrasound-assisted extraction (UAE) and methanol were chosen for further optimization. The experimental data were analyzed by Pareto analysis of variance (ANOVA) and second-order polynomial models were developed using multiple regression analysis. The model developed showed a good fit with the experimental data with a high coefficient of correlation (R2) and predictive ability (predicted R2). An optimization study was performed and the optimal extraction conditions were sample-to-solvent ratio value 1.5:10; extraction time of 10 minutes, and methanol concentration of 100%.
Co-Authors Endang Lukitaningsih Nanang Fakhrudin, Nanang