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Pathogenicity Biofilm formation of Enterococcus faecalis Nur Asmah
Journal of Syiah Kuala Dentistry Society Vol 5, No 1 (2020): June 2020
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v5i1.20011

Biofilm formation is closely related to the pathogenicity of E. faecalis in persistent root canal infections. Limited information is available about the ability and characteristics of E. faecalis biofilm-forming in the persistent pathogenicity of root canal infections. Based on these problems, the purpose of this paper is to improve the molecular understanding of E. faecalis on virulence factors associated with biofilm formation against persistent root canal infections to support laboratory diagnosis and therapy of oral E. faecalis. In conclusion, the release of cytokines triggers the dlt gene of LTA to improving: homeostasis, autolytic activity, and bacterial envelope properties. The role of cytolysin activated by the cylLL and cylLS genes improving the survival ability of E. Faecalis. Hyaluronidase will facilitate other bacteria to migrate from the root canal to periapical lesions resulting in the triggering of toxin production, which will increase damage and inflammation in the host. Enterococcus faecalis, through dentine matrix formation, hydrolyze collagen and induce apatite deposition in developing biofilms. Besides, these bacteria can also increase their tolerance to antimicrobials by blocking the inflammatory response's acid reaction. Alkaline conditions will neutralize the lactic acid secreted by osteoclasts to absorb hard tissue

Molecular aspects of Enterococcus faecalis virulence Nur Asmah
Journal of Syiah Kuala Dentistry Society Vol 5, No 2 (2020): December 2020
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v5i2.20020

The Enterococcus faecalis (E. Faecalis) virulence factor plays an essential role in the persistence of root canal infection. Virulence factors of Enterococcus faecalis such as lipoteichoic acid, extracellular superoxide, gelatinase, hyaluronidase, and cytolysin are known to increase the ability of Enterococcus faecalis to induce inflammatory processes, colonization formation, and increase resistance. The virulence factor of E. faecalis is mediated by LTA, which has pattern recognition receptors for cytokine release, bone resorption and triggers apoptosis of osteoblasts, osteoclasts, periodontal connective tissue, macrophages, and neutrophils, which have implications for the occurrence of periradicular lesions. Lipoteichoic acid is also involved in producing D-alanine, which stimulates signals to other bacteria to form biofilms. The E. faecalis will change the balance of oxygen radical production in the periapical lesion, fragment collagen. The fight host's defense mechanisms that cause periapical damage and worsening bone loss. Furthermore, cytolysin will respond to changes in oxygen conditions in the depleting root canals for the dominance of E. faecalis against other bacteria. The energy needs of E. faecalis that assisted by hyaluronidase, which degrades hyaluronan dentin. İt has to produce disaccharide degradation products that can be transported and metabolized intracellularly. These materials hydrolyzing the substrate to obtain essential carbon for its growth. This article aims to describe the molecular aspect of E. faecalis virulence that is involved in root canal infections.

Penanganan kista radikuler pada gigi insisivus lateralis rahang atas dengan menggunakan kalsium hidroksida Management of a radicular cyst of upper lateral incisive by using calcium hydroxide Nur Asmah; Moch. Richata Fadil; Endang Sukartini; Milly Armilia
Journal of Dentomaxillofacial Science Vol. 12 No. 1 (2013): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v12i1.344

Cyst is an enclosed cavity surrounded by epithelial cells and contains cholesterin. Radicular cysts are formed as aresult of chronic inflammation of malassez epithelium, caused by trauma or untreated pulp necrosis. In this case, a 21years-old man came to Clinic of Conservative Dentistry, Faculty of Dentistry, University of Padjadjaran, in Bandungto get dental endodontic treatment on his maxillary right lateral incisor. Patient experienced trauma after a motorcycleaccident ten years ago. Clinical examination with vitality test, percussion test, palpation test showed no complaints.Radiological examination revealed a radiolucent lesion with a clear boundary around the apical. The disorder wasdiagnosed as a radicular cyst of teeth 12. Conventional endodontic treatment performed using calcium hydroxide as aroot canal medication in eight times visiting. The outcome of the treatment was assessed by clinical and radiographicevaluation that showed a reduction of radicular cyst size. It is concluded that conventional endodontic treatment usingcalcium hydroxide as medications is an adequate root canal treatment, that was accompanied by periodic observationcould heal the radicular cysts

Restorasi onlay komposit indirek pada gigi molar kedua rahang bawah kanan Nur Asmah
Makassar Dental Journal Vol. 1 No. 6 (2012): Vol 1 No 6, Desember 2012
Publisher : Makassar Dental Journal PDGI Makassar

Restorasi akhir yang baik merupakan bagian paling penting dari keberhasilan perawatan endodontik, karena dapat mempertahankan sterilitas ruang pulpa dan dapat mencegah terjadinya pencabutan gigi karena kegagalan restorasi. Restorasi komposit terbagi 2 golongan yaitu restorasi komposit direk dan restorasi komposit indirek. Restorasi onlay diindikasikan bila 2 atau lebih bonjol gigi yang hilang dan masih memiliki ketebalan email dan dentin yang masih cukup. Pada kasus ini dilaporkan seorang pasien laki-laki berusia 35 tahun, gigi 47 sudah dirawat endodontik, ingin ditambal sesuai warna gigi alami, pilihan restorasi adalah restorasi onlay komposit indirek, karena memiliki kekuatan dan estetik yang baik.

Restorasi veneer labial komposit direk pada gigi anterior rahang atas yang mengalami white spot dan malformasi Nur Asmah
Makassar Dental Journal Vol. 3 No. 6 (2014): Vol 3 No 6 Desember 2014
Publisher : Makassar Dental Journal PDGI Makassar

Perubahan warna gigi dan posisi gigi yang tidak baik dapat mempengaruhi penampilan dan psikologis seseorang, baik itu terjadi pada usia muda atau dewasa. Terdapat enam jenis pewarnaan spesifik yang sering ditemukan, antara lain pewarnaan tetrasiklin hipoplastik, akibat fluorosis, white spot, gigi non vital, fraktur dan karena penyebab usia. White spot adalah kerusakan dalam pembentukan gigi yang terjadi pada email gigi, yang tampak daerah putih berbatas jelas pada bagian depan mahkota gigi. Veneer adalah sebuah lapisan tipis bahan sewarna gigi yang diaplikasikan pada permukaan gigi yang mengalami perubahan warna. Pada kasus ini dilaporkan seorang pasien laki laki berusia 17 tahun, gigi 12,11 vital, gigi 21 non vital sudah dirawat endodontik, ingin ditambal sesuai warna gigi alami, dengan bentuk gigi yang ideal. Restorasi yang dipertimbangkan pada kasus ini adalah veneer labial komposit direk, karena memiliki kekuatan, ekonomis dan estetik yang baik.

Characteristics and Antibacterial Properties of Film Membrane of Chitosan-Resveratrol for Wound Dressing Basri A. Gani; Nur Asmah; Cut Soraya; Dharli Syafriza; Sri Rezeki; Muhammad Nazar; Subhaini Jakfar; Nurtami Soedarsono
Emerging Science Journal Vol 7, No 3 (2023): June
Publisher : Ital Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28991/ESJ-2023-07-03-012

The research aimed to evaluate the film membrane of Nano Chitosan Resveratrol (NCHR) for biological, physicochemical, and antibacterial properties. Psychochemically, the functional groups of chitosan compounds were examined by FTIR, chemical compounds by GCMS, and the morphology of chitosan and chemical elements by SEM-EDS. Biologically, the characteristics of NCHR were examined by solubility, swelling, permeability, and biodegradation tests. Meanwhile, the antibacterial properties were examined for inhibition of Porphyromonas gingivalis (P. gingivalis) ATCC 33277 by Minimal inhibition concentration (MIC) and growth assessment by spectrophotometry. Nano Chitosan (NCH) has appeared at 1033.85 cm-1 as a sharp peak indicating the P=O group and contains anti-toxicity compounds (Ethane, 1,1-diethoxy- (CAS) 1,1-Diethoxye) is 81.06% and antioxidant compounds Limonene is (1.28%). In addition, NCH has chemical elements, Oxygen Weight (69.4%), calcium (19.7%), magnesium (6.6%), and phosphorus (4.3%). NaCl 0.9%, PBS, and Aquades. In addition, it has an excellent index of water vapor transmission rate (WVTR) in all solvents (R2³ 0.95). The NCHR membrane film is bacteriostatic (≤ 300 CFU/mL) with each value of Minimal Inhibition Concentration (MIC) >15 mm. The Nano chitosan contains antitoxic, antioxidant, and antibacterial compounds with high oxygen elements. The film membrane of nano chitosan resveratrol can maintain the stability of changes in pH with a very high solubility index, swelling index, and WVTR index, as well as good biodegradation and antibacterial properties. Doi: 10.28991/ESJ-2023-07-03-012 Full Text: PDF

Efektivitas Antibakteri Ekstrak Tulang Ikan Cakalang (Katsuwonus pelamis) terhadap Streptococcus mutans dan Porphyromonas gingivalis Syamsiah Syam; Nur Asmah; Nabila A. L. Lestari
e-GiGi Vol. 11 No. 2 (2023): e-GiGi
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/eg.v11i2.46942

Abstract: Dental and oral diseases are dominated by periodontal disease and tooth decay. The most common type of bacteria that causes periodontal diseases is Porphyromonas gingivalis meanwhile the one that causes dental caries is Streptococcus mutans. Skipjack tuna (Katsuwonus pelamis) bones contain high calcium which can produce hydroxyapatite often used for tooth remineralization. This study aimed to determine the antibacterial effectiveness of skipjack tuna bones against Porphyromonas gingivalis and Streptococcus mutans. This was a laboratory experimental study using post test only control design. Data were analyzed with One Way Anova, using five treatments and five repetitions. The results showed that the mean diameter of the inhibition zone of Streptococcus mutans against 5% skipjack tuna bone extract was 8.63±0.24 mm; 10% extract was 9.28±0.12 mm; and 15% extract was 11.05 0.95 mm (p<0.01). Meanwhile, the mean diameter of the inhibition zone of Porphyromonas gingivalis against 5% skipjack tuna bone extract was 6.99±0.94 mm; 10% extract was 7.86 0.63 mm; and 15% extract was 12.63±0.55 mm (p<0.01). In conclusion, skipjack tuna bone extract (Katsuwonus pelamis) at 5%, 10%, and 15% can inhibit Streptococcus mutans and Porphyromonas gingivalis. Extract with the highest concentration (15%) is classified as strong category against both types of bacteria in this study. Keywords: caries; periodontal diseases; antibacterial; skipjack bone Abstrak: Masalah mulut didominasi oleh penyakit periodontal dan kerusakan gigi. Bakteri penyebab tersering penyakit periodontal ialah Porphyromonas gingivalis sedangkan pada penyakit karies gigi ialah Streptococcus mutans. Tulang ikan cakalang (Katsuwonus pelamis) mempunyai kandungan kalsium tinggi yang dapat menghasilkan hidroksiapatit untuk proses remineralisasi gigi. Penelitian ini bertujuan untuk mengetahui efektivitas antibakteri tulang ikan cakalang terhadap Porphyromonas gingivalis dan Streptococcus mutans. Jenis penelitian ialah eksperimental laboratorium dengan post test only control design. Pengambilan sampel dilakukan secara random sampling. Data penelitian dianalisis dengan One Way Anova, yaitu menggunakan lima perlakuan dan lima kali pengulangan. Hasil penelitian memperlihatkan bahwa diameter zona daya hambat Streptococcus mutans dari ekstrak tulang ikan cakalang konsentrasi 5% sebesar 8,63±0,24 mm; konsentrasi 10% sebesar 9,28±0,12 mm; dan konsentrasi 15% sebesar 11,05±0,95 mm (p<0,01). Diameter zona daya hambat Porphyromonas gingivalis dari ekstrak tulang ikan cakalang konsentrasi 5% sebesar 6,99±0,94 mm; konsentrasi 10% sebesar 7,86±0,63 mm; dan konsentrasi 15% sebesar 12,63±0,55 mm (p<0,01). Simpulan penelitian ini ialah ekstrak tulang ikan cakalang (Katsuwonus pelamis) konsentrasi 5%, 10%, dan 15% dapat menghambat bakteri Streptococcus mutans dan Porphyromonas gingivalis. Ekstrak dengan konsentrasi tertinggi (15%) digolongkan memiliki daya hambat kuat terhadap kedua bakteri uji. Kata kunci: karies; penyakit periodontal; antibakteri; tulang ikan cakalang

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