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All Journal Pharmaciana: Jurnal Kefarmasian MPI (Media Pharmaceutica Indonesiana) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat)

Ema Pristi Yunita

Departemen Farmasi Fakultas Kedokteran Universitas Brawijaya

Author-ID : 3093983

Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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The effect of physician prescribing patterns based on ESC guidelines on morbidity improvement among heart failure patients Ema Pristi Yunita; Anindhita Dwi Safitri; Ardian Rizal
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Data from Basic Health Research shows the prevalence of heart failure in Indonesia is between 0.1% to 0.3% of the entire Indonesian population. This number is predicted to increase from year to year. Heart failure is a complex syndrome that can cause abnormalities in the structure and function of the heart. Based on the ejection fraction values, there are three types of heart failure, namely HFrEF (EF: < 40%), HFmrEF (EF: 40-49%), and HFpEF (EF: â‰¥ 50%). Considering that the type of heart failure requiring treatment according to ESC guidelines is only HFrEF, however, this study would also evaluate the effect of physician prescribing patterns on the morbidity of HFmrEF. The recommendations from ESC guidelines to the treatment of HFrEF that can reduce morbidity and mortality are three medication combinations, namely ACE inhibitors/angiotensin receptor blockers, beta-blockers, and aldosterone antagonists. Therefore, this study aims to determine the effect of the suitability of physician prescribing patterns according to ESC guidelines on improving the morbidity of heart failure patients in HFrEF and HFmrEF type. Improvements in morbidity can be seen from the quality of life score and frequency of hospitalization by using questionnaires. The study was conducted in the cardiology outpatient clinic of Dr. Saiful Anwar General Hospital and Islamic Hospital of Aisyiyah in April-May 2019. Subjects who participated in the study were 57 patients. The One-way ANOVA test results showed no significant difference between physician prescribing patterns of quality of life scores on HFrEF (p = 0.944) while the Kruskal Wallis test for the same parameters on HFmrEF also showed insignificant results (p = 0.210). The Kruskal Wallis test results showed no significant difference between the patterns of physician prescribing to the frequency of hospitalization in both HFrEF and HFmrEF (p = 0.260; p = 0.428). The results showed that physician prescribing patterns in accordance with ESC guidelines resulted in the best quality of life scores on HFrEF. The lowest frequency of hospitalization was also shown in HFrEF patients who received treatment according to ESC guidelines.

Multidisciplinary Synergy of Health Workers as an Effort to Improve Public Health Status Ema Pristi Yunita
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 3 (2021): September
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

The low level of public knowledge of the importance of preventing diseases and maintaining health can increase morbidity and mortality. In this community service, counseling and integrated health services were provided by seven health study programs at Universitas Brawijaya (UB). This community service aimed to improve public health status and identify the correlation between education level and public behavior and their health condition. All health workers wrote the health status of the participants on the community health cards. The participants were asked to answer questionnaires as a feedback process and an analysis of the activity. A total of 95.33% of the participants stated that these activities were useful while 4.67% stated that the activities were useless. The results of the gamma correlation test showed a significant correlation between education level and public behavior towards complaints about aches and pains, coughs and colds, diarrhea, chest pains, and itching. On complaints about aches and pains and abdominal pain, the higher the education level, the worse the behavior in dealing with the complaints. Collaborative activities among health workers are needed to overcome public health problems. A high education level of the public does not always guarantee the accuracy of certain actions chosen to overcome various early symptoms of diseases. Therefore, the role of health workers is needed in providing health education to the public regardless of their education levels.

Penyuluhan Waspada Swamedikasi pada Penyakit Degeneratif serta Identifikasi Tanda-Tanda Vital dan Gaya Hidup Masyarakat terhadap Risiko Penyakit Degeneratif Ema Pristi Yunita
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 1, No 1 (2021)
Publisher : JTRIDHARMA

Swamedikasi untuk penyakit degeneratif di masyarakat terutama pada kelompok lansia tanpa disertai edukasi yang baik dapat memperburuk kondisi kesehatan masyarakat. Tanda-tanda vital (TTV) dan gaya hidup tidak sehat masyarakat yang tidak pernah dipantau oleh tenaga kesehatan juga dapat meningkatkan risiko maupun memperberat penyakit degeneratif. Tujuan kegiatan ini adalah memberi pemahaman kepada masyarakat tentang pentingnya kesadaran waspada swamedikasi pada penyakit degeneratif serta perlunya monitoring rutin TTV dan memperbaiki gaya hidup untuk menurunkan morbiditas serta mortalitas terutama terkait penyakit degeneratif. Metode yang digunakan dalam kegiatan ini yaitu monitoring TTV (tekanan darah dan denyut nadi), wawancara, konsultasi mandiri, dan penyuluhan. Sebagian besar peserta kegiatan termasuk kelompok lansia (74,19%) yang mengalami penyakit degeneratif antara lain dislipidemia (48,39%), hipertensi (35,48%), diabetes melitus (29,03%), strok (19,35%), dan penyakit jantung (19,35%). Dari hasil identifikasi TTV diketahui bahwa 54,84% peserta kegiatan mengalami hipertensi dan 48,39% lainnya menunjukkan denyut nadi yang normal. Berdasarkan identifikasi gaya hidup, sebagian besar peserta tidak memiliki kebiasaan merokok (87,10%), tidak suka begadang (45,16%), tidak memiliki kebiasaan minum kopi (70,97%), tidak memiliki kebiasaan makan makanan yang berat di malam hari (48,39%), tidak suka makan makanan yang asin (70,97%), tidak suka minum minuman berenergi (93,55%), dan tidak suka minum jamu (83,87%), tetapi sering minum minuman yang manis (41,94%).

Front Matter Jurnal TRI DHARMA MANDIRI Volume 1 Nomor 2 Ema Pristi Yunita
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 1, No 2 (2021)
Publisher : JTRIDHARMA

Evaluasi Penggunaan Aspirin Jangka Panjang terhadap Fungsi Ginjal Pasien Penyakit Jantung Koroner Ema Pristi Yunita; Puji Astuti Nur Hidayanti; Cholid Tri Tjahjono
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 10, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.53312

Low-dose aspirin (75-100 mg/day) is a long-term platelet antiaggregation therapy for certain coronary heart disease (CHD) patients. This study aims to evaluate the long-term use of aspirin on kidney function by examining the changes in the levels of serum creatinine, blood urea nitrogen (BUN), and creatinine clearance of CHD patients. The research method used was a prospective observational cohort analysis. The number of study subjects was 37 CHD patients who took 80 mg/day of aspirin and never experienced kidney disease. Serum creatinine and BUN levels were examined in the 1st and 3rd month of the study. Patient creatinine clearance values were calculated using the Cockcroft-Gault equation. The results of the study showed that the mean levels of serum creatinine, BUN, and creatinine clearance on the 1st and 3rd month were 1.03 ± 0.27 mg/dL and 1.03 ± 0.29 mg/dL; 13.05 ± 4.10 mg/dL and 14.65 ± 4.44 mg/dL; 73.16 ± 18.14 mL/min and 72.92 ± 19.76 mL/min, respectively. The paired t-test results showed that the differences in the mean of creatinine serum, BUN, and creatinine clearance on the 1st and 3rd month were not statistically significant (p > 0.05). The One Way ANOVA test results on the effect of the duration of aspirin use on kidney function were also not statistically significant (p > 0.05) however there is a tendency to decrease creatinine clearance and increase in serum creatinine and BUN. Long-term use of low-dose aspirin has the potential to cause a decrease in kidney function that is seen from a decrease in creatinine clearance as well as an increase in serum creatinine and BUN.

Front Matter Jurnal TRI DHARMA MANDIRI Volume 2 Nomor 1 apt. Ema Pristi Yunita, S.Farm., M.Farm.Klin. (Scopus ID : 57213688462; Sinta ID : 5983214)
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 2, No 1 (2022)
Publisher : JTRIDHARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.01.0

TRAINING ON CONTRACEPTIVE SELECTION BASED ON FAMILY PLANNING ACCEPTORS’ CLINICAL CONDITIONS Ema Pristi Yunita; Oktavia Rahayu Adianingsih; Sri Winarsih
Caring : Jurnal Pengabdian Masyarakat Vol 2, No 3 (2022): CARING Jurnal Pengabdian Masyarakat (Desember 2022)
Publisher : Caring : Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2022.002.03.2

A population growth rate of 1.22% has become a national problem and makes Indonesia one of the most densely populated countries in the world. Meanwhile, the population growth rate in Malang city, which has been successfully decreasing, needs to be sustained. This community service aimed to help maintain this achievement by providing training on contraception in the pharmaceutical care aspect, especially in clinical pharmacy. It is because if the contraceptive preparation chosen is birth control pills, the choice of hormonal contraception needs to be adjusted to the family planning acceptor’s clinical condition and emphasizing the importance of medication adherence is required. The problem-solving method used in this community service activity was Participatory Action Research (PAR). Techniques for delivering material were done through presentation, training, and practices using visual aids. The activity was located at the meeting hall of RW 08, Bunulrejo Village, Blimbing District, Malang City and was carried out for two months with the highlight of the event in March 2022. Three types of questionnaire instruments used were personal data and data related to the history of contraceptive methods used, knowledge instrument, and activity evaluation instrument. The knowledge instrument has been declared valid and reliable through the results of the Pearson and Cronbach’s Alpha correlation tests. The results of this community service activity showed that 43.48% of the participants experienced class 1 obesity, and 9% suffered from comorbid hypertension. The pre-test and post-test results related to knowledge showed an increase of 32.46 points. Besides, the evaluation questionnaire of the three aspects of the assessment, including process, benefits, and training presenters, showed an average score of ≥ 3.50. In short, class 1 obesity and hypertension comorbidity are the conditions to consider when choosing hormonal contraceptive preparations for the community, although the prevalence was relatively small. Participant knowledge related to contraception increased after the training. From the evaluation questionnaire results, the participants considered that the series of training activities went very well.

Front Matter Jurnal TRI DHARMA MANDIRI Volume 2 Nomor 2 apt. Ema Pristi Yunita, S.Farm., M.Farm.Klin. (Scopus ID : 57213688462; Sinta ID : 5983214)
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 2, No 2 (2022)
Publisher : JTRIDHARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2022.002.02.0

Front Matter Jurnal TRI DHARMA MANDIRI Volume 3 Nomor 1 apt. Ema Pristi Yunita, S.Farm., M.Farm.Klin. (Scopus ID : 57213688462; Sinta ID : 5983214)
TRI DHARMA MANDIRI: Diseminasi dan Hilirisasi Riset kepada Masyarakat (Jurnal Pengabdian kepada Masyarakat) Vol 3, No 1 (2023)
Publisher : JTRIDHARMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jtridharma.2023.003.01.0

Pengaruh Obat Antituberkulosis Kombinasi RHZE Terhadap Peningkatan Kadar Asam Urat Ika Prima Azzahra; Sri Winarsih; Ema Pristi Yunita
MPI (Media Pharmaceutica Indonesiana) Vol. 5 No. 2 (2023): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v5i2.5925

Tuberkulosis paru merupakan penyakit infeksius yang diakibatkan oleh bakteri Mycobacterium tuberculosis. Pasien tuberkulosis paru memperoleh pengobatan kombinasi obat antituberkulosis (OAT). Pada pengobatan kategori I, pasien mendapatkan kombinasi RHZE pada tahap intensif selama 2 bulan. Adanya obat pirazinamid (Z) dan etambutol (E) dalam regimen terapi berisiko menyebabkan efek samping berupa peningkatan kadar asam urat di dalam darah. Efek samping tersebut dapat menyebabkan problem medis berupa gout maupun gangguan fungsi ginjal. Oleh karena itu, apoteker harus memantau risiko efek samping OAT pada pasien. Penelitian ini bertujuan untuk menganalisis pengaruh penggunaan OAT kombinasi RHZE terhadap kadar asam urat pasien. Penelitian yang dilakukan di Puskesmas Citangkil Kota Cilegon ini merupakan penelitian observasional kohort. Penelitian dilakukan selama bulan April – Juni 2023. Jumlah subjek penelitian yang memenuhi kriteria inklusi dan eksklusi sebanyak 36 pasien. Pemeriksaan kadar asam urat dilakukan sebelum pasien minum OAT (minggu ke-0) dan minggu ke-4 setelah minum OAT. Hasil penelitian menunjukkan bahwa rerata kadar asam urat pasien laki-laki pada minggu ke-0 dan minggu ke-4 masing-masing sebesar 5,09 ± 0,9 mg/dL dan 12,02 ± 1,59 mg/dL. Sementara itu, pada pasien perempuan masing-masing sebesar 5,06 ± 0,94 mg/dL dan 11,98 ± 1,69 mg/dL. Hasil uji t berpasangan menunjukkan adanya perbedaan yang signifikan secara statistik terhadap rerata kadar asam urat pada minggu ke-0 dan ke-4 (p < 0,001). Dari hasil penelitian ini diketahui bahwa penggunaan OAT RHZE pada pasien tuberkulosis paru selama 4 minggu dapat menyebabkan peningkatan kadar asam urat. Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis bacteria. Patients with pulmonary tuberculosis undergo combination anti-tuberculosis drug (ATD) therapy. In category I treatment, patients receive a combination of RHZE during the intensive phase for 2 months. The inclusion of pyrazinamide (Z) and ethambutol (E) in the therapy regimen carries the risk of side effects, including an increase in uric acid levels in the bloodstream. These side effects can result in medical issues, such as gout and kidney function disturbances. As a result, it is crucial for pharmacists to monitor the potential side effects of ATD in patients. This study aimed to analyze the impact of RHZE combination ATD use on patients’ uric acid levels. This research was conducted at Citangkil Community Health Center in Cilegon City, and was an observational cohort study started from April to June 2023, involving a total of 36 patients who met the inclusion and exclusion criteria. Uric acid levels were assessed both before patients initiated ATD treatment (week 0) and at week 4 after commencing ATD. The findings indicated that the mean uric acid levels for male patients at week 0 and week 4 were 5.09 ± 0.9 mg/dL and 12.02 ± 1.59 mg/dL, respectively. For female patients, the corresponding levels were 5.06 ± 0.94 mg/dL and 11.98 ± 1.69 mg/dL. Paired t-test results revealed a statistically significant difference in mean uric acid levels between week 0 and week 4 (p < 0.001). In conclusion, the use of RHZE combination ATD in pulmonary tuberculosis patients for 4 weeks could lead to an elevation in uric acid levels.

Co-Authors Anindhita Dwi Safitri Ardian Rizal Cholid Tri Tjahjono Ika Prima Azzahra Oktavia Rahayu Adianingsih Puji Astuti Nur Hidayanti Sri Winarsih Sri Winarsih

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