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All Journal INDONESIAN JOURNAL OF PHARMACY
Tamizharasi Sengodan
assistant professor
Medicine & Pharmacology

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Naringenin-Loaded TPGS Polymeric Nanosuspension: In-Vitro and In-Vivo Anti-Inflammatory Activity Sumathi Rajamani; Tamizharasi Sengodan; Sivakumar Thangavelu; Nikhitha K Shanmukhan; Arun Radhakrishnan
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1047.977 KB) | DOI: 10.14499/indonesianjpharm30iss3pp225

Abstract

Naringenin, (NAR) from Citrus grandis(L.) Osbeck, family Rutaceae, exhibit extensive pharmacological action, lacks significance in application due to low aqueous solubility approximately  0.214 mg/ml, which results in low bioavailability of 5.8%. Nanosuspension of NAR (NARNS) was prepared in our previous studies using high pressure homogenization adding various polymers. All these formulations were characterized and as a continuation of our work formulations was further evaluated for their anti-inflammatory activity by in-vitro and in-vivo methods. Denaturation of protein method and membrane stabilization methods were chosen for in-vitro evaluation. In-vivo studies performed were acute inflammatory studies (carrageenan-induced paw oedema) and chronic inflammatory studies (cotton pellet granuloma) on Wistar albino rats. The studies demonstrated that the NAR and NARNS at a dose of 50 mg/kg P.O. have a potent activity compared to the standard drug diclofenac.  The percentage protection against inflammation exhibited by NARNS was highly significant compared to NAR.
Co-Authors Arun Radhakrishnan Nikhitha K Shanmukhan Sivakumar Thangavelu Sumathi Rajamani