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All Journal INDONESIAN JOURNAL OF PHARMACY
Muhammad Da’i
Faculty Of Pharmacy, Universitas Muhammadiyah Surakarta
Medicine & Pharmacology

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Structure and cytotoxic activity relationship of curcumin derivatives on Myeloma cells Supardjan Amir Margono; Muhammad Da’i
Indonesian Journal of Pharmacy Vol 16 No 2, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (167.012 KB) | DOI: 10.14499/indonesianjpharm0iss0pp100-104

Abstract

Curcumin is a compound having broad spectrum of biological activities for example as anti-cancer. The aim of this research is to evaluate the relationship of structure and the cytotoxicity effect of curcumin and its derivatives on myeloma cell line. Some alkyl curcumin derivatives have beensynthesized and evaluated for the activity on myeloma cell lines with direct counting method. The IC50 values for curcumin, 4-methyl, 4-ethyl, 4-propyl, 4-isopropyl,4-benzyl, 4-phenyl dan 4-paramethylphenylcurcumin are 8.78, 3.45, 2.93, 2.18, 4.20, 3.87, >100, >100 μM respectively. Its seem that the activity of the curcumin derivatives is corelated to the stabilization of β diketone moiety and positive partial charge of those compound.Key words: Curcumin, myeloma cells, Curcumin derivatives
Co-Authors Supardjan Amir Margono