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Erika Maharani
Faculty of Medicine, University of Indonesia/ Harapan Kita National Cardiovascular Center
Medicine & Pharmacology

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Potential use of isosorbide dinitrate As a new drug for tilt table test of young adult subject: A study of haemodynamic effects Yuniadi, Yoga; Maharani, Erika; Prakoso, Radityo; Saragih, Robert E.; Munawar, Muhammad
Medical Journal of Indonesia Vol 15, No 1 (2006): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.626 KB) | DOI: 10.13181/mji.v15i1.210

Abstract

Vasovagal syncope is a common health problem in young adult population. Tilt table test (TTT) is the only method to diagnose vasovagal syncope. Since isoprenaline as a standard provocative drug of TTT is hard to be found in Indonesia, we study the haemodynamic effect of isosorbide dinitrate (ISDN) which has similar venous pooling effect with isoprenaline. Seventeen young healthy adult subjects (age of 28.6 ± 4.7 year old, and 14 males) underwent TTT using 400 μg ISDN spray sublingually as a provocative drug. The haemodynamic changes were observed during baseline and provocative phase. None of 17 subjects experienced of syncope. Although, the systolic, diastolic, and mean arterial blood pressure were significantly decreased and the heart rate significantly increased after ISDN administration, but the changes were not sufficient to cause syncopal event. In conclusion sublingual ISDN spray during TTT of young healthy adult subject changes haemodynamic measures but did not cause syncope. These results give a reasonable basic for ISDN usage as provocative drug of TTT. (Med J Indones 2006; 15:24-9)Keywords: Syncope, vasovagal, tilt table test, nitrate
Left ventricular hypertrophy are associated with increased ostial pulmonary vein diameter Yuniadi, Yoga; Prakoso, Radityo; Maharani, Erika; Nagawijaya, Budi; Munawar, Muhammad
Medical Journal of Indonesia Vol 15, No 3 (2006): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.519 KB) | DOI: 10.13181/mji.v15i3.234

Abstract

Atrial fibrillation (AF), which is called as a global epidemic disease, frequently found in hypertensive patients with left ventricular hypertrophy (LVH). Pulmonary vein (PV), which is known to have an important role in AF initiation and maintenance, increases in its diameter during AF. We sought to investigate PVs diameter changes in LVH with sinus rhythm. Of 70 hypertensive patients with sinus rhythm, 42 subjects demonstrated LVH. The mean ostial diameter of patient with and without LVH, assessed by doing spiral multisliced CT scan in the axial plane, were as follow: right superior (RSPV) of 19.6±2.78 vs 17.8±1.93 (p = 0.003), right inferior (RIPV) of 18.4±3.12 vs 16.0±2.19 (p < 0.001), left superior (LSPV) of 18.1±2.62 vs 16.0±2.16 (p < 0.001), and left inferior (LIPV) of 15.9±1.93 vs 15.4±1.85 mm (p = 0.284), respectively. Even during sinus rhythm, LVH causes PV dilation. This result might give an explanation of frequent AF prevalence in hypertensive patients. (Med J Indones 2006; 15:173-6) Keywords: Pulmonary veins, Left ventricular hypertrophy
Co-Authors Budi Nagawijaya Muhammad Munawar Radityo Prakoso Robert E. Saragih Yoga Yuniadi Yoga Yuniadi