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All Journal Jurnal Kedokteran Diponegoro Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Yetty Movieta Nancy
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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ASSOCIATION BETWEEN LOW BIRTH WEIGHT (LBW) INFANTS AND TH INCIDENCE OF ACUTE LEUKEMIA IN CHILDREN Roidlotul Nikmah Annafi; Yetty Movieta Nancy; Mulyono Mulyono; Dwi Retnoningrum
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (482.54 KB) | DOI: 10.14710/dmj.v9i2.27077

Abstract

Background: Acute leukemia is a blood cells malignancy disease originating from the bone marrow, characterized by the proliferation of white blood cells, with manifestations of abnormal cells in peripheral blood. Perinatal conditions such as low birth weight can increase the risk of leukemia in children. Low birth weight infants cause resistance towards GH and IGF-1 which triggers leukemia. The purpose of this study is to determine the correlation between low birth weight infants and the incidence of acute leukemia in children. Methods: A case-control analytic observational study, carried out at RSUP Dr. Kariadi. The study was conducted in July-October 2019. Subjects were patients with acute leukemia as the case group and non-leukemia patients as the control group aged 0-18 years old. Data was collected by interview using a questionnaire and then data analysis was conducted using the chi square test. Results: Research subjects 82 people, aged 0-18 years old consisting of 46 males (56.1%) and 36 females (43.9%). No significant relationship was found between low birth weight infants with the incidence of acute leukemia in children. Different results were obtained for the duration of breastfeeding with the incidence of acute leukemia in children with P = 0.002. Conclusion: There was no association between low birth weight (LBW) infants and the incidence of acute leukemia in children.Keywords: acute leukemia in children, LBW
LEUKEMIA MEGAKARIOBLASTIK AKUT PADA SEORANG ANAK Nyoman Suci Widyastiti; Ima Arum Lestarini; Yetty Movieta Nancy; Umi S Intansari; R. Lindeman
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 14, No 2 (2008)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v14i2.906

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Acute Megakaryoblastic Leukemia (FAB AML M7) occurs in all age groups with two peaks in distribution. The one is in adults and theother in children 1 to 3 years of age especially in those with Down’s syndrome. The diagnosis of AML M7 requires more than 30% of thenucleated bone marrow cells being megakaryoblasts. The AML M7 was under diagnosed before the availability of monoclonal antibodies.The more common types of AML MO-M6 have to be excluded by morphological and cytochemical analysis whereas immunology is neededto exclude ALL. The megakaryocytic nature of the leukemia has to be proven by ultrastructural demonstration of platelet peroxidase or byimmunological demonstration of CD61, CD42, CD41 on the surface of the leukemic blasts. Megakaryocytic/megakaryoblastic leukemiasshow a wide morphologic spectrum. Cytoplasmic blebs and protrusions are the most prominent feature of many cases. The nuclei ofthese cells are round with more finely reticulated chromatin and with prominent nucleoli. The megakaryoblastic nature of these cells canbe suggested by morphology. Cytochemistry is of limited diagnostic value in megakaryoblastic leukemias. Usually it is used to excludethe more common types of leukemia. An eighteen months girl was admitted to hospital with anemia and hepatosplenomegaly. There isdismorphic - hypertelorism face and enlargement of neck lymph nodes. The laboratory examination found anemia, hyperleukocytosis with75 % blast cells. Morphologically the blast cells show prominent blebs and cytoplasmic budding resemble features of budding platelets.The cytochemistry staining for granulocyte and erythrocyte lineages were negative. The expressions of lymphoid and myeloid lineagesmarkers by immunoflowcytometry method were also negative. Cytogenetic examination was followed. The physical and laboratoryexamination result conclude a child with Acute Megakaryoblastic Leukemia. Cytogenetic examination was followed
Co-Authors Dwi Retnoningrum Ima Arum Lestarini Mulyono Mulyono Nyoman Suci Widyastiti R. Lindeman Roidlotul Nikmah Annafi Umi S Intansari