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All Journal e-CliniC Jurnal e-Biomedik JURNAL BIOMEDIK Medical Scope Journal (MSJ)
Jeanette I. Ch. Manoppo
Fakultas Kedokteran Universitas Sam Ratulangi Manado
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : JURNAL BIOMEDIK

 1 
PERAN INFLAMASI DALAM PATOFISIOLOGI SEPSIS DAN SYOK SEPTIK PADA ANAK Oematan, Yosef; Manoppo, Jeanette I. Ch.; Runtunuwu, Ari L.
Jurnal Biomedik : JBM Vol 1, No 3 (2009): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.1.3.2009.831

Abstract

Abstract: As one of the main causes of death in critically patients in intensive care unit, sepsis remains a health problem in developing and industrialized countries. Sepsis spectrum varies from invasion of microbes into the bloodstream associated with early signs of circulatory disorders (tachycardia, tachypneu, peripheral vasodilatation, fever, hypothermia) to circulatory collapse, multiple organ failures, and even death. Sepsis and septic shock occurs due to uncontrolled inflammation and immune system failure. Activated CD4 T cells are programmed to secrete mediators that have either one of two distinct and antagonistic profiles: proinflammatory [type 1 helper T-cell (Th1)] or anti-inflammatory [type 2 helper T-cell (Th2)]. There is a complex interaction between these proinflammatory and anti-inflammatory mediators in sepsis and septic shock. The balance of these two kinds of mediators helps the involved tissues in repairing and healing processes. High mortality rates of sepsis occur when/if the levels of both kinds of mediators are high. Prognosis of patients is affected by the severity of infections, previous health status, and host responses. Understanding the role of inflammation in the pathophysiology of sepsis and septic shock may improve the ability of health workers in diagnosis and handling of sepsis patients. Key words: Sepsis, septic shock, inflammation, proinflammatory and antiinflammatory mediators. Abstrak: Sebagai salah satu penyebab utama kematian terutama pada penderita di unit perawatan intensif, sepsis tetap merupakan masalah kesehatan baik di negara berkembang maupun negara maju. Spektrum sepsis bervariasi dari invasi mikroba ke aliran darah dengan tanda awal gangguan sirkulasi (takikardia, takipnu, vasodilatasi perifer, demam atau hipotermi) hingga kolaps sirkulasi, kegagalan sistem multiorgan bahkan kematian. Sepsis dan syok septik terjadi akibat tidak terkontrolnya inflamasi dan kegagalan system imun. Sel T CD4 teraktivasi menyekresi mediator yang memiliki salah satu dari dua profil yang berbeda, yakni: proinflamasi [sel T-helper tipe 1 (Th1)] atau anti-inflamasi [sel T-helper tipe 2 (Th2)]. Terdapat interaksi yang kompleks antara sejumlah mediator proinflamasi dan anti inflamasi pada sepsis dan syok septik. Keseimbangan antara kedua jenis mediator dapat membantu perbaikan dan pemulihan jaringan. Angka kematian akan tinggi bila kadar keduanya tinggi. Prognosis penderita dipengaruhi oleh beratnya infeksi, status kesehatan sebelumnya dan respon host. Dengan memahami kontribusi inflamasi dalam patofisiologi sepsis dan syok septik dapat meningkatkan kemampuan tenaga kesehatan dalam menegakkan diagnosis dan menangani penderita sepsis. Kata kunci: Sepsis, syok septik, inflamasi, mediator proinflamasi dan anti-inflamasi
Gambaran Mikrobiota Usus dan Konsistensi Tinja pada Bayi Sehat Usia 0-6 Bulan yang Mendapat ASI dan Susu Formula Logor, Narita T; Manoppo, Jeanette I. Ch.; Tatura, Suryadi N. N.
Jurnal Biomedik : JBM Vol 13, No 2 (2021): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.13.2.2021.31782

Abstract

Abstract: The gut microbiota affects the maturation of the immune system, absorption of nutrients and the avoidance of colonization of pathogens, and the stool consistency can reflect the tolerance of gastrointestinal tract and activity in the ecosystem of the colon. The intake of infants in early life affects the gut microbiota and stool consistency, there are differences in the description of the intestinal microbiota and the stool consistency in infants who are given breast milk and infant formula. This study aims to compare the description of gut microbiota and stool consistency in healthy infants aged 0-6 months who are breastfed and infant formula. This study was in the form of a literature review. The literature was taken from three databases, namely Pubmed, Google scholar and pediatric extract. The keywords used were gut microbiota, stool consistency, breast milk and infant formula. After being selected by exclusion inclusion criteria, it was obtained 13 literature. There are 13 literatures examining the description of the gut microbiota and stool consistency in infants who are breastfed, standard infan formula and supplemented infant formula; probiotics, prebiotics, synbiotics, sn-2 palmitate and protein. In conclusion, breastfed infants have a lower diversity of the gut microbiota in early life and will increase with age, a low diversity indicates a healthy gut characteristic if caused by breastfeeding. The stool consistency in breastfed infant is softer than in infants who receive standard infant formula and supplemental infant formulas.Key words: gut microbiota, stool consistency, breast milk, infant formula  Abstrak: Mikrobiota usus mempengaruhi pematangan system kekebalan, penyerapan nutrisi serta menghindari kolonisasi patogen, dan konsistensi tinja dapat menggambarkan toleransi dari gastrointestinal dan aktivitas di ekosistem usus besar. Asupan bayi diawal kehidupan mempengaruhi mikrobiota usus dan konsistensi tinja, terdapat perbedaan gambaran mikrobiota usus dan konsistensi tinja pada bayi yang diberi Air Susu Ibu (ASI) dan susu formula. Penelitian ini bertujuan untuk mengetahui perbedaan gambaran mikrobiota usus dan konsistensi tinja pada bayi sehat usia 0-6 bulan yang mendapat ASI dan susu formula. Penelitian ini dalam bentuk literature review. Literature diambil dari tiga database yaitu Pubmed, Google scholar dan sari pediatric. Kata kunci yang digunakan yaitu gut microbiota, stool consistency, breast milk dan infant formula. Setelah diseleksi dengan kriteria inklusi eksklusi, didapatkan 13 literatur. Terdapat 13 literatur yang meneliti gambaran microbiota usus dan konsistensi tinja pada bayi yang mendapat ASI, susu formula standar dan susu formula dengan tambahan ; probiotik, prebiotik, sinbiotik, sn-2 palmitate dan protein. Sebagai simpulan, bayi yang mendapat ASI memiliki keragaman mikrobiota usus yang rendah diawal kehidupan dan kemudian akan meningkat seiring bertambahnya usia, keragaman yang rendah menunjukan ciri usus yang sehat jika dikarenakan pemberian ASI. Konsistensi tinja pada bayi dengan ASI lebih lunak dibandingkan dengan bayi yang mendapat susu formula standar dan susu formula dengan tambahan.Kata kunci: mikrobiota usus, konsistensi tinja, ASI, susu formula
Co-Authors Adrian Umboh Ari L. Runtunuwu Fatmawati Latamu, Fatmawati Gunawan, Gregorius Logor, Narita T Lorencia, . Marlina G. O. Soentpiet, Marlina G. O. Max F. J. Mantik Mona C. U. Aman Pojoh, Venita S. Rocky Wilar Rompis, Yulke R. Y. Rony Hakim Sabriani, Jehan Suryadi N. N. Tatura, Suryadi N. N. Valentine Umboh, Valentine Yosef Oematan