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All Journal e-CliniC JURNAL BIOMEDIK Jurnal Kedokteran Klinik
Valentine Umboh, Valentine
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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PERBANDINGAN JENIS KONSUMSI AIR MINUM DENGAN KRISTALURIA PADA ANAK Umboh, Adrian; Umboh, Valentine
JKK (Jurnal Kedokteran Klinik) Vol 1, No 2 (2017): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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Abstract

The sources of  drinking water should be qualified both in chemistry, physics, radioactive or bacteriological. One of the parameters in terms of the quality of water is the amount of deposits of minerals such as calcium and magnesium ions. Water consumption of high calcium can increase urine calcium excretion and the process of early occurrence of kidney stones. This research aims to analyze the difference of urinary calcium excretion in children based on the consumption of well water, bottled water and water from a drinking water company and there is not kristaluria. The design of the study was observational, analytic approach to cut the latitude. This research was conducted in three places, on the island of Gangga, Manado and Bitung in April until the month of November 2016. Urinary calcium excretion was measured by calculating the ratio of urine calcium against creatinin urine. And measured also levels of calcium in drinking water. Data were analyzed with Anova test followed by the Fisher test is meaningful and logistical regression. The result p 0.05 was considered meaningful <. On this research obtained 112 children met the criteria of inclusion, the mean excretion of urinary calcium is obtained from the overall sample is 0.143 mg/dl. There is a very meaningful distinction between samples mengkonsumi water Company drinking water and bottled water as well as samples that consume water Company drinking water and well water with a value of p < 0.0001. In the sample who consume bottled water and well water not obtained urine calcium excretion that difference means p = 0.073. In this study also brings about the relationship between calcium excretion meaning apparent urine hiperkalsiuria of events. These relationships meet the logistical regression equations p = 1/1 + e (0,722-+4, 55x). From this research it can be concluded that calcium levels from each different drinking water and may cause a difference in calcium excretion of urine as well as related events kristaluria. Key words: water, kristaluria, kidney stones
Gambaran Fungsi Hati pada Sepsis Neonatorum di RSUP Prof. Dr. R. D. Kandou Manado Lorencia, .; Manoppo, Jeanette I. Ch.; Umboh, Valentine
e-CliniC Vol 8, No 1 (2020): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v8i1.27188

Abstract

Abstract: Neonatal sepsis is a clinical syndrome that consists of nonspecific symptoms and infection signs, occuring with bacteremia in the first 28 days of life. SGOT and SGPT abnormalities as well as hypoalbuminemia can be found in neonatal sepsis patients. This study was aimed to obtain the overview of liver function especially SGOT, SGPT and albumin in neonatal sepsis patients at NICU of Prof. Dr. R. D. Kandou Hospital. This was a retrospective and descriptive study. Data were obtained from the patients’ medical records. The results showed that the percentage of sepsis patients that had mild increased SGOT level was 47.9%. Meanwhile, the SGPT level was more often normal (81.7%). Hypoalbuminemia was found in 54 patients (76.1%), more frequent in male infants (80.9%). Increased SGOT and SGPT levels were more frequent in male infants; 51.1% for mild increased SGOT and 12.8% for mild increased SGPT. In conclusion, among neonatal sepsis increased SGOT levels were more often in mild form meanwhile increased SGPT levels were rare. Increased SGOT and SGPT levels and decreased albumin levels were more common among male infants.Keywords: SGOT, SGPT, albumin, neonatal sepsis Abstrak: Sepsis neonatorum merupakan sindroma klinis yang terdiri dari gejala-gejala nonspesifik dan tanda-tanda infeksi, terjadi bersamaan dengan bakteremia pada 28 hari pertama kehidupan. Abnormalitas SGOT dan SGPT serta hipoalbuminemia dapat ditemukan pada pasien sepsis neonatorum. Penelitian ini bertujuan untuk mengetahui gambaran fungsi hati secara khusus SGOT, SGPT, dan albumin pada pasien sepsis neonatorum di NICU RSUP Prof. Dr. R.D. Kandou. Jenis penelitian ialah deskriptif retrospektif menggunakan data rekam medik pasien sepsis neonatorum. Hasil penelitian mendapatkan persentase pasien sepsis yang mengalami peningkatan ringan kadar SGOT sebesar 47,9%. Kadar SGPT lebih sering ditemukan normal (81,7%). Hipoalbuminemia dijumpai pada 54 pasien (76,1%), lebih sering pada bayi laki-laki (80,9%). Peningkatan SGOT dan SGPT berdasarkan jenis kelamin lebih sering pada bayi laki-laki dan dalam bentuk peningkatan ringan yaitu sebesar 51,1% untuk SGOT dan 12,8% untuk SGPT. Simpulan penelitian ini ialah pada pasien sepsis neonatorum peningkatan kadar SGOT paling sering dalam bentuk peningkatan ringan sedangkan peningkatan kadar SGPT jarang didapatkan. Peningkatan ringan SGOT dan SGPT serta penurunan albumin lebih sering dijumpai pada bayi laki-laki.Kata kunci: SGOT, SGPT, albumin, sepsis neonatorum
CLINICAL AND LABORATORY PROFILES OF URINARY TRACT INFECTION AMONG CHILDREN AT PROF. DR. R. D. KANDOU HOSPITAL MANADO Umboh, Valentine; Umboh, Adrian
JURNAL BIOMEDIK : JBM Vol 8, No 2 (2016): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.8.2.2016.12674

Abstract

Abstrak: Infeksi saluran kencing (ISK)masih sering ditemukan pada anak-anak dan berperan dalam tingginya jumlah pasien yang dirawat di rumah sakit. Oleh karena itudibutuhkan diagnosis dan penanganan dini terhadap pasien ISK. Penelitian ini bertujuan untuk menentukan profil klinik dan laboratorik ISK pada pasien yang dirawat di Bagian Anak RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini ialah retrospektif menggunakan data pasien dari Desember 2009 sampai Desember 2014. Hasil penelitian mendapatkan 65 pasien terdiagnosis ISK berusia 0-15 tahun terdiri dari 37 berjenis kelamin perempuan dan 27 berjenis kelamin laki-laki. Data rekam medik mengenai gambaran klinis dan hasil laboratorium memperlihatkan persentae tertinggi ialah demam (76,6%) diikuti mual dan muntah (26,6%), nyeri perut(17,2%), and diare (14,0%). Pada hasil urinalisisdidapatkan pH urin <6,5 (62,5%) dan pH urin 6,5-8,0 (27,5%). Kuman tersering dari hasil kultur urin ialah Proteus sp. (32,8%), Staphylococcus aureus (20,%), dan Escherichia coli (10,9%). Simpulan: Gambaran klinik dan laboratorik dari anak-anak dengan infeksi saluran kencing di RSUP Prof. Dr. R. D. Kandou Manado tidak berbeda bermakna dengan di negara maju dan di negara berkembang lainnya. Walaupun demikian hasil penelitian ini dapat membantu pertimbangan diagnosis dini pada pasien anak.Kata kunci: infeksi saluran kencing, kultur urin, demam, urinalisisAbstract: Urinary tract infection (UTI) is still common among children all over the world and cause a significant number of patient admission to the hospital. Keeping in view the high incidence of UTI in children with associated morbidity and mortality, it is imperative to diagnose and to treat the infection as early as possible. This study aimed to determine the clinical and laboratory profiles of UTI among patients admitted at Pediatric Ward Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective study. Clinical and laboratory presentation of the UTI patients were obtained from the medical records from December 2009 to December 2014. The results showed that there were 65 cases of UTI aged 0 to 15 years in this study consisted of 37 females and 27 males. Fever was the commonest clinical presentation (76.6%) followed by nausea and vomitting (26.6%), flank pain (17.2%), and diarrhea (14.0%). From the urinalysis it was found that the urine pHs were <6.5 (62.5%) and 6.5-8.0 (27.5%). Proteus sp. (32.8%), Staphylococcus aureus (20.3%), and Escherichia coli(10.9%) were the most common bacteria found in urinary culture. Conclusion: Clinical and laboratory profile of urinary tract infection in children at Pediatric Ward Prof. Dr. R. D. Kandou Hospital Manado was not significantly different from that of other developing and developed countries. Albeit, it willhelp us in confirming early diagnosis of urinary tract infection among pediatrics patients.Keywords: urinary tract infection, urine culture, fever, urinalysis
Luaran Pada Anak-Anak Dengan Sindroma Nefrotik Sensitif Steroid Di RSUP PROF. Dr. R. D. Kandou Manado Umboh, Valentine; Tandiawan, Ledy; Umboh, Adrian
JKK (Jurnal Kedokteran Klinik) Vol 3, No 2 (2019): JURNAL KEDOKTERAN KLINIK
Publisher : FAKULTAS KEDOKTERAN UNSRAT

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Abstract

ABSTRACTBackground : Nephrotic Syndrolme (NS) is the most common kidney disorder in children. Based on therapy, NS consist of steroid sensitive nephotic syndrome (SSNS) ans steroid resistant nephrotic syndrome (SRNS). Nearly 50% of children with SSNS have a frequently relapsing (FR) or steroid dependent (SD) course, experiencing steroid toxicities. Objective :To examine the outcome in childrens with SSNS at Prof. DR. R.D.Kandou Manado Hospital  Methods : A retrospective study of patients from January 2013 to December 2017. 123 of patients diagnosed SSNS, from 6 month to 18 years of age admitted in the Pediatric Nephrology clinic of Prof. DR. R.D.Kandou Manado Hospital. We record the clinical and laboratory presentation of these patients from medical records. Result : Sample (n=123) children with SSNS. 62 children  include inclusi criteria. There are 36(58%) children experience FRNS, and 26(42%) children experience SDNS. The median age of onset was 36 months. The median time to the first relapse was 3 months in FRgroup, and 14 day in SD group. There are 9(25%) children with FR and 6(23%) with SD,  experiences SRNS. Conclusion : Treatment in the first periode and shorter median time in SSNS is a predictor of FRNS or SDNS.Keywords : Nephrotic syndrome, sensitive steroid, steroid resistant, steroid dependent, frequent relap.ABSTRAKLatar Belakang : Sindroma Nefrotik (SN) merupakan kelainan ginjal tersering pada anak. Berdasarkan respon terhadap terapi, SN dibagi menjadi Sindrom Nefrotik Sensitif Steroid (SNSS) dan Sindrom Nefrotik Resisten Steroid (SNSR). Sebagian besar anak dengan SNSS memiliki kemungkinan terjadi sindrom nefrotik relaps sering (SNSR) atau sindrom nefrotik tergantung steroid (SNDS), dikarenakan mengalami toksisitas steroid Tujuan : Untuk melihat luaran dari anak-anak dengan SNSS di RSUP Prof. Dr. R. D. Kandou Manado. Metode : Penelitian retrospektif, yang dilakukan pada anak-anak dengan diagnosa SNSS dari Januari 2013 sampai dengan Desember 2017, yang dirawat di unit rawat jalan Nefrologi anak bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado. Data pemeriksaan dan hasil laboratorium diambil dari rekam medis  Hasil : Sample (n=123) anak dengan SNSS. 62 anak yang termasuk kriteria inklusi. Didapatkan 36 (58%) anak menfalami SN relap sering, dan 26 (42%) anak mengalami SN dependen steroid. Dengan rata-rata umur onset yaitu 36 bulan.  Dan rata-rata waktu kambuh pertama kali adalah 3 bulan pada relaps sering dan 14 hari pada kelompok dependen steroid. Dan didapatkan 9 (25%) anak dengan relaps sering dan 6 (23%) anak dengan dependen steroid mengalami sindrome nefrotik resisten steroid. Kesimpulan : Pengobatan adekuat pada episode pertama dan waktu paruh yang singkat pada pengobatan SNSS merupakan prediktor terjadinya SN relaps sering atau SN dependen steriod.Kata kunci     : Sindroma nefrotik, steroid sensitif, resisten steroid, dependen steroid, relaps sering.        
Gambaran Klinis Glomerulonefritis Akut pada Anak di RSUP Prof. Dr. R. D. Kandou Manado Umboh, Valentine; Umboh, Adrian
Jurnal Biomedik : JBM Vol 10, No 3 (2018): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.10.3.2018.21985

Abstract

Abstract: Acute glomerulonephritis (AGN) is characterized by classical clinical triad of sudden onset of edema, hematuria, and hypertension. The clinical picture is unmistakable but laboratory evidences lend additional diagnostic support. This study was aimed to evaluate the clinical profile and complication of children with AGN at Prof. DR. R.D.Kandou Manado Hospital. This was a retrospective study of patients from December 2009 to December 2014. This study was perfomed on 45 patients diagnosed as AGN, aged 1-15 years, admitted at the Pediatric Ward of Prof. Dr. R. D. Kandou Manado Hospital. Data of the clinical and laboratory presentation of these patients were obtained from the medical records. The results showed that the majority of patients (88.8%) were between 5-12 years; only 5 patients below 5 years of age. AGN was twice as common in males as it was in females. It was ushered as acute onset of edema (64.4%), hypertension (46.6%), tea-colored urine (33.3%), and fever (28.8%). The ASTO titre was elevated above 250 Todd units in 68.8% of cases. Of 45 patients, only 18 patients were checked for C3 level and the result showed that all of the 18 patients had C3 <50 mg/dL. The main complications were hypertensive encephalopathy (8.9%) and crisis hyper-tension (4.4%). Conclusion: Clinical profiles of AGN in children in this study are not significantly different from those of other developing countries. Therefore, it will help us a lot in confirming the diagnosis of patients with AGN.Keywords: acute glomerulonephritis, clinical profile, ASTO, complicationAbstrak: Glomerulonefritis akut (GNA) mempunyai karakteristik berupa trias gejala klasik yaitu edema yang terjadi secara tiba-tiba, hematuria, dan hipertensi. Meskipun gambaran klinisnya cukup jelas, tetapi hasil pemeriksaan laboratorium dapat memberikan tambahan untuk mendukung diagnosis. Penelitian ini bertujuan untuk mengevaluasi gambaran klinis dan komplikasi dari GNA yang terjadi pada anak di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah retrospektif pada pasien-pasien dari periode Desember 2009-Desember 2014. Sebanyak 45 pasien yang didiagnosis GNA dengan rentang usia mulai dari 1-15 tahun yang dirawat di bangsal anak rumah sakit Prof. Dr. R. D. Kandou dimasukkan ke dalam penelitian ini. Data mengenai gambaran klinis dan hasil pemeriksaan laboratorium pasien diperoleh dari rekam medik. Hasil peneltiian mendapatkan bahwa sebagian besar pasien (88,8%) berusia 5-12 tahun, hanya 5 pasien dengan usia kurang dari 5 tahun. Anak laki–laki dua kali lebih sering terkena daripada anak perempuan. Penyakit ini ditandai dengan edema yang terjadi secara tiba-tiba (64,4%), hipertensi (46,6%), urin berwarna seperti teh (33,3%), dan demam (28,8%). Peningkatan titer ASTO di atas 250 Todd unit dijumpai pada 68,8% kasus. Dari 45 pasien, hanya 18 pasien yang diperiksakan nilai C3 dan hasilnya memperlihatkan bahwa 18 pasien tersebut memiliki hasil C3 <50 mg/dL. Komplikasi yang sering terjadi ialah hipertensi ensefalopati (8,9%) dan krisis hipertensi (4,4%). Simpulan: Gambaran klinis GNA pada anak di penelitian ini tidak jauh berbeda dengan yang dijumpai di negara berkembang lainnya. Hal ini dapat membantu dalam mendiagnosis pasien dengan glomerulonefritis akut.Kata kunci: glomerulonefritis akut, gambaran klinis, ASTO, komplikasi
Gejala Klinis dan Pemeriksaan Penunjang pada Neonatus Terinfeksi COVID-19 Rampengan, Jason; Rompis, Johnny; Umboh, Valentine
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i1.32304

Abstract

Abstract: COVID-19 is spreading at an extremely rapid rate and can affect all age groups, albeit, information about clinical symptoms and laboratory examinations of COVID-19 I in neonates is still quite limited. This study was aimed to determine the clinical symptoms, radiographic examinations especially CT-scans, and laboratory tests that could appear in neonates suffering from COVID-19. This was a literature review study using three databases, namely Pubmed, Clinical Key, and Google Scholar. The keywords used were Covid-19 / SARS-CoV-2 AND Neonatus AND sign and symptoms AND laboratory. The selection based on inclusion and exclusion criteria, obtained 15 case report studies, three retrospective studies, one observational study, and one cohort study. The review revealed that the most frequent clinical features that appeared were fever (54.8%), dyspnoea (35.4%), and cough (29%). Meanwhile, for CT-Scan radiographs, there were 14 of 31 neonates (45.2%) did not show any abnormalities or normal. The most frequent abnormal image was ground glass opacity (GGO) (29%). Among laboratory examinations, lymphopenia was the most common abnormality (32.2%). Moreover, leukocytosis, leukopenia, thrombocytopenia, increased PCT, AST, etc. could also occur. Of all the reviewed literatures, there were no death cases of neonates died due to COVID-19. In conclusion, fever, dyspnea, cough, and lymphopenia are the most common findings as well as GGO in the CT-Scan radiograph.Keywords: COVID-19, neonates Abstrak: COVID-19 menyebar dengan sangat pesat dan dapat menjangkiti semua kelompok usia namun informasi mengenai gejala klinis dan pemeriksaan laboratorium terhadap kelompok neonatus masih terbatas. Penelitian ini bertujuan untuk mengetahui gambaran klinis, pemeriksaan radiografi khususnya CT-Scan, dan pemeriksaan laboratorium yang bisa muncul pada neonatus dengan COVID-19. Jenis penelitian ialah literature review dengan pencarian data menggunakan tiga database yaitu Pubmed, Clinical Key, dan Google Scholar. Kata kunci yang digunakan yaitu Covid-19/ SARS-CoV-2 AND Neonatus AND sign and symptom AND laboratory. Hasil seleksi berdasarkan kriteria inklusi dan ekslusi mendapatkan 15 penelitian case report, tiga retrospective study, satu observational study, dan satu cohort study. Hasil kajian menunjukkan bahwa gambaran klinis yang paling sering muncul ialah demam (54,8%), sesak (35,4%), dan batuk (29%). Pemeriksaan radiografi CT-Scan, neonatus yang tidak menunjukkan kelainan (normal) terdapat pada 14 dari 31 neonatus diamati (45,2%), sedangkan kelainan yang sering muncul ialah ground glass opacity/GGO (29%). Pada pemeriksaan laboratorium, limfopenia merupakan kelainan tersering (32,2%), sedangkan leukositosis, leukopenia, trombositopenia, peningkatan PCT, AST, dll juga bisa terjadi. Dari semua literatur yang dikaji, tidak ditemukan kasus kematian neonatus akibat COVID-19. Simpulan penelitian ini ialah gambaran klinis yang paling sering muncul pada neonatus ialah demam, sesak, dan batuk, limfopenia, dan GGO pada CT-Scan.Kata kunci: COVID-19, neonatus
Co-Authors Adrian Umboh Jeanette I. Ch. Manoppo Johnny Rompis Lorencia, . Rampengan, Jason Tandiawan, Ledy