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Journal : Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

OPTIMASI KOMBINASI EKSTRAK BUAH MENGKUDU (Morinda citrifolia L) DAN DAUN MAHKOTA DEWA (Phaleria macrocarpa (Scheff) Boerl.) PADA FORMULA SABUN TRANSPARAN DENGAN METODE FACTORIAL DESIGN Intan Martha Cahyani; Bekti Nugraheni; Suwarmi Suwarmi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.338 KB) | DOI: 10.31942/jiffk.v11i1.1286

Abstract

ABSTRACT Extracts of mengkudu fruit and mahkota dewa leaf each contain compounds that can be efficacious antibacterial Staphylococcus Aureus (acne-causing bacteria), but at high concentrations. The combination of both is expected to improve the efficiency and effectiveness of the use if the dosage form is formulated in a transparent soap. Selection of dosage forms based on a transparent soap acceptabilitas reasons. This study aims to determine the effect of the use of each and interactions extract of mengkudu fruit and mahkota dewa leaf in diameter clear zone antibacterial activity test by the method of pitting and dilution method with a parameter number of colony can then be determined comparison of the two extracts were having antibacterial activity optimum. The test results stated good use of each and combinations can enhance the clear zone according to the equation Y = 0.811 + 0.011 + 0.007 B + A 1.56. 10-5 AB, the parameters of the number of colonies also give the same result Y = 42.781 to 0.316 A - 0.228 0.006 A B + B. Optimal combination obtained extract concentration of 30% mengkudu fruit extract and 40% mahkota dewa leaf extract. Test the antibacterial activity of a combination of transparent soap mengkudu fruit and mahkota dewa leaf extracts with an optimal combination produces a clear zone diameter of 2.509 cm. Keywords : extracts of mengkudu fruit, extract of mahkota dewa, Optimization, transparent soap.
IDENTIFIKASI DAN ANALISIS KANDUNGAN MAKRONUTRIEN GLUKOMANAN UMBI PORANG (Amorphophallus onchophyllus) Bekti Nugraheni; Anastasia Setyopuspito P; Yustisia Dian Advistasari
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 2 Desember 2018
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (250.528 KB) | DOI: 10.31942/jiffk.v15i2.2570

Abstract

ABSTRACTThe purpose of this study is identification and analysis of the macronutrient glucomannan from porang tuber (Amorphophallus onchopyllus). The stages done in this research are extraction, identification, and macronutrient analysis of glucomannan of the porang tuber. Prior to extraction, the oxalic acid was removed from porang tuber using mixture of 2% lime juice and 5% lime, then the glucomannans was extracted using ultrasonic method. The glucomannan then was identified using Fourier transform infra red spectrometer (FTIR) instrument and macronutrient analyzer such as Soxhlet method for fats and fibers, Kjedahl method for protein, and Antrone method for carbohydrates. The results of identification using FTIR showed the presence of β-pyranose at wave numbers of 900-810 cm -1 . The carbonyl on on acetyl group was found at 1726 cm-1 . The area between 870-800 cm-1 showed the β-glycosidic and β-manosidic compounds. The C-O ether group was shown in the area of 1260-1200 cm -1 , while for C-O alcohol was shown in the area of 1050 cm-1 showed the C-O bond in alcohol. At 2925 cm-1 it showed C-H, while at 3000-3700 cm-1 O-H group. The levels of porang glucomannan macronutrients included fat at 0.50%, protein at 1.05%, fiber at 22.34%, and carbohydrates at 31.33%.Key word: Porang tuber, glucomannan, FTIR, macronutrient analysis.
EFEK PEMBERIAN GLUKOMANAN UMBI PORANG (Amorphophallus oncophyllus Prain ex Hook. f.) TERHADAP KADAR KOLESTEROL TOTAL DARAH TIKUS YANG DIBERI DIET TINGGI LEMAK Bekti Nugraheni; Intan Martha Cahyani; Kyky Herlyanti
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (90.27 KB) | DOI: 10.31942/jiffk.v11i2.1366

Abstract

ABSTRACTIndonesia is a country with abundant natural resources, one of which tubers. Plants types of tubers that have a lot of glucomannan content of the tuber porang. Glucomannan is used as a diet in patients with hypercholesterolemia. Glucomannan from tubers porang (Amorphophallus oncophyllus Prain ex Hook.f.) serves as a water-soluble fiber and have a low calorie.The purpose of this study was to determine the effect of glucomannan tuber porang (Amorphophallus oncophyllus Prain ex Hook.f.) to decrease total blood cholesterol mice fed a high-fat diet and to determine what dose of glucomannan tubers porang most effective for lowering blood cholesterol.The treatment in this study is glucomannan flour dose of 25 mg / kg; 50 mg / kg; and 100 mg / kg. The population in this study was a white rat (Rattus norvegicus) males aged 2-3 months with BB ± 200 g.Giving glucomannan porang tubers dose 25 mg / kg; 50 mg / kg; and 100 mg / kg give effect to the reduction in total blood cholesterol mice fed a high-fat diet. Effective dose for lowering total cholesterol levels of mice that is 50 mg / kg.Keywords: glucomannan tuber porang (Amorphophallus oncophyllus Prain ex Hook.f.), total cholesterol.