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All Journal Majalah Kedokteran Sriwijaya JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Muthmainnah Arifin
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Identifikasi Polimorfisme Insersi/Delesi Gen Angiotensin Converting Enzym Intron 16 Pada Pasien Preeklampsia di RS. Dr. Muhammad Hoesin Palembang Muthmainnah Arifin; Mgs Irsan Saleh; Subandrate Subandrate
Majalah Kedokteran Sriwijaya Vol 46, No 3 (2014): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36706/mks.v46i3.2709

Abstract

Preeklampsia adalah penyakit kehamilan dengan gejala hipertensi dan proteinuria yang timbul pada usia kehamilan diatas 20 minggu. Preeklampsia terkait dengan polimorfisme insersi/delesi (I/D) gen angiotensin converting enzym (ACE) intron 16. Polimorfisme ini dapat meningkatkan aktivitas ACE yang mengakibatkan gagalnya remodelling arteri spiralis sehingga terjadi preeklampsia. Namun, penelitian ini belum pernah dilakukan sebelumnya pada pasien preeklampsia di RSMH Palembang. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi polimorfisme insersi/delesi gen ACE intron 16 pada penderita preeklampsia di RSMH Palembang.Penelitian ini merupakan penelitian deskriptif observasional dengan sampel sebanyak 32 orang pasien preeklampsia. Identifikasi polimorfisme insersi/delesi (I/D) gen ACE intron 16 dilakukan dengan teknik PCR amplifikasi yang ditentukan dengan menggunakan primer spesifik. Primer tersebut menggunakan teknik mutagenesis situs terarah yang mengintroduksi mutasi titik ke suatu situs tertentu.Genotipe mutan homozigot (DD) sebanyak 0%, genotipe mutan heterozigot (ID) sebanyak 40,6%, dan genotipe wild type (II) sebanyak 59,4%. Jumlah alel I dan D gen ACE yang ditemukan masing-masing sebanyak 79,7% dan 20,3% pada pasien preeklampsia di RSMH Palembang.Genotipe wild type lebih banyak ditemukan pada pasien preeklampsia di RSMH Palembang (59,4%).
Analisis Potensi Curcumin Kunyit (Curcuma longa) Sebagai Agen Neuroproktektor, Antiinflamasi, dan Antioksidan Surya Wijaya; Muthmainnah Arifin
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 1 No 2 (2012): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

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Abstract

ABSTRACT Alzheimer is the most common type of dementia disorders affecting people all over the world. Alzheimer not only contribute to complications, disability, and high mortality rate, but also has implications in psychiatry and economic aspects. Unfortunately, until now there is no medical management to treat Alzheimer effectively. One of the herbs that is used as Alzheimer therapy is turmeric (Ctercuma longa) with its main components, curcumin. The aim of paper writing is to investigate the mechanism and potential applications of turmeric's curcumin as innovative therapy for Alzheimer patient. Data collection methods is literature study. whereas data analysis method is inductive. Curcumin has potential as management modality of Alzheimer because it serves as a neuroprotective agent by inhibiting the formation protein β -arnyloid and tau protein cycle, decreasing the activity of β -secretase and acetilcolinesterase, and antidislipidemia. Curcumin also acts as an anti-inflammatory agent through inhibition of NF-kB activity, COX-2, lipooxygenase, AP-1, iNOS, and Egr-1. In addition to these two effects, curcumin also has potential as an antioxidant agent through lowering activity of peroxidase, reactive oxygen species (ROS) and oxidative stress induced by homocysteine. This suggests that turmeric's curcumin has strong potential for fluffier development into alternative Alzheimer therapies.
Co-Authors Mgs Irsan Saleh Subandrate Surya Wijaya