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All Journal The Indonesian Biomedical Journal SCRIPTA SCORE Scientific Medical Journal Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Rosmayanti Syafriani Siregar
Departemen Genitourinary, Fakultas Kedokteran, Universitas Sumatera Utara, Medan
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Renal Function in Children with β-Thalassemia Major Treated with Iron Chelating Agent Olga Rasiyanti Siregar; Rosmayanti Syafriani Siregar; Bidasari Lubis
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1053

Abstract

BACKGROUND: Thalassemia is a disorder of inherited blood and inticated by the abnormal hemoglobin. Transfusion and iron chelation are part of thalassemia management. Iron chelating agent reduces complications due to the excess iron as a result of repeated transfusions, hence, increasing the survival rate. However, prolonged intake of iron chelating agent may increase the risk of renal function impairment. To date, evaluation of renal function in children with β-thalassemia in Medan has never been reported. The objective of this study was to evaluate renal function and other factors in children with β-thalassemia.METHODS: Fourty-five children with β-thalassemia was recruited in this study. Renal function, represented by estimated glomerular filtration rate (eGFR)and serum ferritin levels were examined. The measurement of eGFR was using Schwartz method.RESULTS: Decreased eGFR observed in some the children (2 patients) with β-thalassemia major treated with iron chelating agent. None of the factors examined had association with serum creatinine level. Children's age and duration of iron chelating agent intake had positive correlation with their eGFR (r=0.506, p<0.001 and r=0.518, p<0.001, respectively). However, serum ferritin levels was not a predictor for renal function impairment.CONCLUSION: Most of children with β-thalassemia major treated with iron chelating agent have normal renal function, nevertheless, decreased renal function is observed in few children. Highlighted, renal function examinations should be performed routinely as iron chelating agent administration is a long-term therapy in children with β-thalassemia major.KEYWORDS: β-thalassemia major, renal function, serum ferritin levels, iron chelating agent
Knowledge and Attitude of Medan Selayang Citizens Toward Kidney Diseases in Children Viria Milenia; Rosmayanti Syafriani Siregar; Tasrif Hamdi; Ririe Fachrina Malisie
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 1 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (698.63 KB) | DOI: 10.32734/jetromi.v4i1.7819

Abstract

Background. Renal disease define as groups of heterogenous disease that affect the function and structure of kidney. Children with end-stage renal disease (ESRD) have 30 times mortality rate than children without ESRD. Early signs and symptoms should be recognized and risk factors should be identified early so kidney disease could be prevented and slow the progress towards worse condition. Prevention can be done by parents and society by hindering or eliminating risk factor from children that could cause kidney disease.  Therefore, society’s knowledge and attitude towards children’s kidney disease need to be carried out, especially parents,which are child’s first point contact with medical staff.   Objective. To describe the level of knowledge about symptoms, risk factors, treatment and complications of kidney diseases and precautionary attitude of Medan Selayang citizens towards kidney diseases in children. Methods. The research was a descriptive observational study with cross sectional approach. The sampling method used was non-probability sampling with convenient method. Total sample needed in this research is 100 people who were Medan Selayang citizens that brought children to Puskesmas PB II Selayang.This study used questionnaire as research tool. Results : From 100 respondents, 67% knew that children can get kidney disease and 81% agree that some kidney diseases can be prevented. Conclusion. The knowledge of Medan Selayang’s citizens was still lack especially regarding symptoms, risk factors, and complications. The attitude of the citizens was good. 
Peningkatan Tekanan Intraokular pada Sindrom Nefrotik Harida Panduwita Sinaga; Rusdidjas -; Rafita Ramayati; Oke Rina Ramayani; Rosmayanti Siregar; Beatrix Siregar
Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i8.626

Abstract

Sindrom nefrotik (SN) merupakan penyakit ginjal terbanyak pada anak. Tatalaksana medikamantosa utama SN adalah menggunakan kortikosteroid; penggunaan dosis tinggi dan jangka lama dapat memiliki efek samping, salah satunya peningkatan tekanan intraokular. Mekanisme pasti peningkatan tekanan intraokular diinduksi steroid belum diketahui pasti, steroid dapat meningkatkan resistensi pengeluaran aqueous humor.Nephrotic syndrome (NS) is the most common kidney disease in children. Corticosteroid is still preferred as primary treatment. High-dose and long term use of corticosteroids can increase intraocular pressure. The mechanism of steroid-induced increased intraocular pressure is not clearly understood; steroids can increase aqueous humor outflow resistance.
Hubungan Disomnia dan Tekanan Darah pada Remaja Krisnarta Sembiring; Oke Rina Ramayani; Munar Lubis; Rosmayanti Siregar; Beatrix Siregar
Cermin Dunia Kedokteran Vol 44, No 12 (2017): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v44i12.690

Abstract

Disomnia merupakan gangguan tidur yang sering dijumpai pada remaja, disebabkan oleh faktor internal dan eksternal, serta faktor medis dan nonmedis. Disomnia dapat berdampak buruk pada kesehatan remaja. Disomnia dapat didiagnosis secara objektif maupun subjektif. Salah satu komplikasi disomnia adalah peningkatan tekanan darah. Peningkatan tekanan darah pada remaja akan menyebabkan hipertensi saat dewasa serta berbagai masalah kardiovaskuler lainnya.Dyssomnia is a common sleep disturbance in adolescents; it is caused by internal and external factors along with medical and nonmedical factors. Dyssomnia may have negative impact on adolescent’s health. One of it’s complications is increased blood pressure. Increased blood pressure in adolescent will lead to hypertension in adult together with other cardiovascular problems.
Hubungan ASI Eksklusif dan Enuresis Primer pada Anak Syahreza Hasibuan; Oke Rina Ramayani; Munar Lubis; Rosmayanti Siregar; Beatrix Siregar
Cermin Dunia Kedokteran Vol 47, No 8 (2020): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i8.782

Abstract

Enuresis adalah keluarnya air kemih yang tidak disadari dan berulang pada anak berusia 5 tahun atau lebih yang diharapkan sudah dapat mengendalikan proses berkemihnya. Istilah enuresis primer dipakai untuk anak yang belum pernah berhenti mengompol sejak bayi. Salah satu penyebab enuresis primer adalah keterlambatan maturasi sistem saraf pusat. ASI merupakan nutrisi yang ideal untuk bagi perkembangan sistem saraf. Pemberian ASI eksklusif menunjukkan manfaat besar dalam perkembangan visual, kognitif, dan neurologis anak sehingga berperan dalam mencegah enuresis pada anak. Hal ini didukung oleh beberapa penelitian yang melaporkan hubungan antara pemberian ASI eksklusif dengan enuresis pada anak.Enuresis is repeated involuntary discharge of urine in children 5 years of age or older expected to be able to control the micturition. Primary enuresis is when children 5 years of age or older still bed-wetting. One of the causes of primary enuresis is delayed maturation of the central nervous system. Exclusive breastfeeding has beneficial effect in visual, cognitive, and neurological development in children; it may have a role in preventing enuresis. Several studies report the correlation between exclusive breastfeeding and enuresis prevention in children. 
Hubungan ASI Eksklusif dan Enuresis Primer pada Anak Syahreza Hasibuan; Oke Rina Ramayani; Munar Lubis; Rosmayanti Siregar; Beatrix Siregar
Cermin Dunia Kedokteran Vol 47 No 6 (2020): Kardiologi & Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v47i6.630

Abstract

Enuresis adalah keluarnya air kemih yang tidak disadari dan berulang pada anak berusia 5 tahun atau lebih yang diharapkan sudah dapat mengendalikan proses berkemihnya. Istilah enuresis primer dipakai untuk anak yang belum pernah berhenti mengompol sejak bayi. Salah satu penyebab enuresis primer adalah keterlambatan maturasi sistem saraf pusat. ASI merupakan nutrisi yang ideal untuk bagi perkembangan sistem saraf. Pemberian ASI eksklusif menunjukkan manfaat besar dalam perkembangan visual, kognitif, dan neurologis anak, sehingga berperan dalam mencegah enuresis pada anak. Hal ini didukung oleh beberapa penelitian yang melaporkan hubungan antara pemberian ASI eksklusif dan enuresis pada anak. Enuresis is repeated involuntary discharge of urine in children 5 years of age or older expected to be able to control the micturition. Primary enuresis is when children 5 years of age or older still bed-wetting. One of the causes of primary enuresis is delayed maturation of the central nervous system. Exclusive breastfeeding has beneficial effect in visual, cognitive, and neurological development in children; it may have a role in preventing enuresis. Several studies report the correlation between exclusive breastfeeding and enuresis prevention in children.
Hubungan Durasi Penggunaan Visual Display Terminal Terhadap Computer Vision Syndrome pada Mahasiswa Fakultas Kedokteran Universitas Sumatera Utara Vincent Wijaya; Dwi Rita Anggraini; Fitriani Lumongga; Rosmayanti Syafriani Siregar
SCRIPTA SCORE Scientific Medical Journal Vol. 4 No. 2 (2023): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v4i2.10534

Abstract

Pendahuluan. Computer Vision Syndrome merupakan sekumpulan gejala penglihatan yang disebabkan oleh paparan Visual Display Terminal berupa computer, smartphone, dan lain lain dalam jangka waktu yang lama. Mahasiswa selama pembelajaran daring terpapar Visual Display Terminal dalam jangka waktu yang panjang, membuat mereka rentan terkena Computer Vision Syndrome. Tujuan. Penelitian ini bertujuan untuk mengetahui pengaruh durasi penggunaan Visual Display Terminal terhadap Computer Vision Syndrome pada mahasiswa Fakultas Kedokteran Universitas Sumatera Utara. Metode. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross-sectional. Penelitian dilakukan di Fakultas Kedokteran Universitas Sumatera Utara pada bulan Agustus 2022. Sampel penelitian yaitu Mahasiswa aktif Fakultas Kedokteran Universitas Sumatera Utara tahun ajaran 2019-2021 diperoleh dengan stratified random sampling. Hasil. Analisis data penelitian menggunakan uji korelasi spearman’s rho rank correlation. Penelitian menunjukkan terdapat adanya hubungan signifikan durasi penggunaan VDT terhadapat CVS (p = 0.03) dengan nilai korelasi yang lemah (d = 0.314). Kesimpulan. Ada hubungan durasi penggunaan lebih dari empat jam secara terus menerus atau pengunaan VDT selama 6 jam terhadap Computer Vision Syndrome, dengan sumber VDT yang paling sering digunakan adalah smartphone.
Peningkatan Tekanan Intraokular pada Sindrom Nefrotik Harida Panduwita Sinaga; Rusdidjas; Rata Ramayati; Oke Rina Ramayani; Rosmayanti Siregar; Beatrix Siregar
Cermin Dunia Kedokteran Vol. 45 No. 8 (2018): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i8.738

Abstract

Sindrom nefrotik (SN) merupakan penyakit ginjal terbanyak pada anak. Tatalaksana medikamantosa utama SN adalah menggunakan kortikosteroid; penggunaan dosis tinggi dan jangka lama dapat memiliki efek samping, salah satunya peningkatan tekanan intraokular. Mekanisme pasti peningkatan tekanan intraokular diinduksi steroid belum diketahui pasti, steroid dapat meningkatkan resistensi pengeluaran aqueous humor.   Nephrotic syndrome (NS) is the most common kidney disease in children. Corticosteroid is still preferred as primary treatment. High-dose and long term use of corticosteroids can increase intraocular pressure. The mechanism of steroid-induced increased intraocular pressure is not clearly understood; steroids can increase aqueous humor outflow resistance.
Co-Authors Beatrix Siregar Beatrix Siregar Beatrix Siregar Bidasari Lubis Dwi Rita Anggraini Fitriani Lumongga Harida Panduwita Sinaga Krisnarta Sembiring Munar Lubis Munar Lubis Oke Rina Ramayani Oke Rina Ramayani Oke Rina Ramayani Olga Rasiyanti Siregar Rafita Ramayati Rata Ramayati Ririe Fachrina Malisie Rusdidjas Rusdidjas - Syahreza Hasibuan Syahreza Hasibuan Tasrif Hamdi Vincent Wijaya Viria Milenia