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All Journal The Indonesian Biomedical Journal Majalah Biomorfologi (Biomorphology Journal) AKSONA
Soebagjo, Hendrian Dwikoloso
Department Of Ophthalmology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Cryotherapy Has No Significant Effect on MMP-9 and TGF-β1 Expression in Fungal Corneal Ulcer Dwita Permatasari; Hendrian Dwikoloso Soebagjo; Ismi Zuhria; Nila Kurniasari; Hari Basuki Notobroto; Cinintha Nandini
The Indonesian Biomedical Journal Vol 13, No 3 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i3.1516

Abstract

BACKGROUND: Usually, surgical intervention is needed to eradicate the fungal microorganism that cause fungal corneal ulcers. However, since surgical intervention is invasive, the latest technology uses cryotherapy in treating it. Cryotherapy plays a vital role in the wound healing process. We aimed to evaluate is to study the decreased expression of matrix metalloproteinase 9 (MMP-9) and transforming growth factor β1 (TGF-β1) in fungal corneal ulcers after the administration of cryotherapy.METHODS: Aspergillus flavus fungus was injected to the intrastromal corneas of all Sprague Dawley rats. The rats were divided into four groups, the first group was not given any therapy, the second group was given topical natamycin therapy, the third group was given cryotherapy, and the fourth group was given a combination between cryotherapy and topical natamycin therapy. Therapy was given after five days of follow up on the formation of a corneal ulcer. After four days of therapy, the eyes were enucleated to determine MMP-9 and TGF-β1 expression.RESULTS: The result in the third group showed lower MMP-9 expression (20.0±10.0% cells per field of view) compared to the second group (40.0±20.0% cells per field of view) and the fourth group (30.0±25.0% cells per field of view), but had the same MMP-9 expression value as the first group. There was no significant difference in MMP-9 expression between the four groups (p=0.356). The third group reduced more TGF-β1 expression (10.0±12.50% cells per field of view) compared to the fourth group (30±27.5% cells per field of view) and the first group (30±32.5% cells per field of view). There was also no significant difference in TGF-β1 between the four groups (p=0.315).CONCLUSION: There is no significant difference in the expression of TGF-β1 and MMP-9 after the cryotherapy treatment.KEYWORDS: corneal ulcer, cryotherapy, MMP-9, TGF-β1
THE RELATIONSHIP OF MECHANICAL OCULAR TRAUMA AND THE BEST-CORRECTED VISUAL ACUITY RESULTS IN DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA Katharina Ratri Benita; Hendrian Dwikoloso Soebagjo; Siprianus Ugroseno Yudho Bintoro
Majalah Biomorfologi Vol. 31 No. 1 (2021): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v31i1.2021.24-30

Abstract

Background: Ocular trauma is an accident caused by a foreign object that affects the eye tissue. Ocular trauma can cause pain and a decrease in the person’s best-corrected visual acuity. Mechanical ocular traumas can cause morphological and functional eye changes that are serious enough to cause blindness. Blindness is often used to describe a severe visual impairment with the remaining visual function. Objective: To determine and to analyze the relationship between mechanical ocular trauma and the best-corrected visual acuity of the patients of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2016-2018. Material and Method: This study was an analytic study with a cross-sectional design. The data were collected using the medical records of the patients of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia in 2016-2018. The population of this study consists of all patients with pure mechanical ocular trauma with a total of 198 subjects. Results: Fisher exact test results showed a value of p=0.054, showing that there was no significant relationship between the best-corrected visual acuity and mechanical ocular trauma. Conclusion: No significant relationship was present between mechanical ocular trauma and the best-corrected visual acuity (BCVA) based on the medical record of patients with ocular trauma in Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, Surabaya, in 2016–2018. Most of the patients had BCVA 6/24 - 2 meter counting finger.
Lamp Light Exposure During Sleep and Sleep Quality of Medical Student Universitas Airlangga Batch 2012 Dyah Ayu Pradnyaparamitha; Hendrian Dwikoloso Soebagjo; Gadis Meinar Sari
AKSONA Vol. 2 No. 1 (2022): JANUARY 2022
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (204.777 KB) | DOI: 10.20473/aksona.v2i1.170

Abstract

Introduction: Sleep disorder commonly happens to teenagers and adults because of light exposure during sleep that affects sleep quality, but the relation of lamp light exposure during sleep and sleep quality of medical students hasn’t been determined previously. Objective: This research aimed to determine the relation of lamp light exposure and sleep quality of Universitas Airlangga’s medical students and to give further information about the right adjustment of lamp light exposure to improve the sleep quality of medical student. Methods: Variables in this cross-sectional designed research were lamp light exposure (on or off) as the independent variable and sleep quality as a dependent variable. The research used the PSQI questionnaire to decide the sleep quality of 115 subjects once a week in a month. The collected data were analyzed by chi-square and fisher’s exact test. Results: Based on the chi-square test, the p-value for lamp light exposure and sleep quality was more than 0.05 (p = 0.863). The results also showed that 74.8%  of medical students had bad quality sleep. Conclusion : In conclusion, there was no relation between lamp light exposure and sleep quality. This research also indicated that most of the subjects had a bad sleep quality so that student should increase their needs for better sleep quality to maintain performance.
Co-Authors Cinintha Nandini Dwita Permatasari Dyah Ayu Pradnyaparamitha Gadis Meinar Sari Hari Basuki Notobroto Ismi Zuhria Katharina Ratri Benita Nila Kurniasari Pradnyaparamitha, Dyah Ayu Sari , Gadis Meinar Yudho, S. Ugroseno