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All Journal Majalah Kedokteran Bandung The Indonesian Biomedical Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Anatomy Journal
Gede Wira Mahadita
Department Of Internal Medicine, Division Of Nephrology, Faculty Of Medicine, Udayana University, Sanglah Hospital, Bali
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Soluble Transferrin Receptor and Soluble Transferrin Receptor/Log Ferritin Ratio are Correlated with Iron Status in Regular Hemodialysis Patients Yenny Kandarini; Gede Wira Mahadita; Sianny Herawati; Anak Agung Wiradewi Lestari; Ketut Suega; I Gde Raka Widiana
The Indonesian Biomedical Journal Vol 13, No 2 (2021)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v13i2.1412

Abstract

BACKGROUND: Monitoring of iron status in chronic kidney disease patients is important, however inflammation may hinder its monitoring. Soluble transferrin receptor (sTfR) is an alternative parameter to overcome this issue, whereas ferritin play a part in the inflammation process. Hence, the correlation between the sTfR ratio and the sTfR/log ferritin ratio with conventional iron status parameters in regular hemodialysis patients is necessary to be evaluated.METHODS: A cross-sectional was conducted in the current study. As many as 5 mL of blood (2 mL for sTfR and 3 mL for serum iron and ferritin levels) was collected. sTfR level was the blood-soluble transferrin receptor level measured by the enzyme-linked immunosorbent assay (ELISA). The amount of ferritin and serum iron was determined using the immunochemiluminescent process. To evaluate the correlation, the Pearson correlation test was used.RESULTS: A total of 80 subjects was included in this study. The mean of hemoglobin was 10.25±1.66 g/dL, serum iron was 58.19±26.56 g/dL, and the median ferritin was 520.4 (49.9-3606) ng/mL. The sTfR was significantly associated only with serum iron levels with a correlation coefficient of r=-0.242; p=0.031. The sTfR/log ferritin was significantly associated with serum iron l evels (InSI)(r=-0.255, p=0.022); and transferrin saturation (r=-0.295; p=0.008).CONCLUSION: sTfR/log ferritin has a negative and significant correlation with serum iron levels and transferrin saturation, while sTfR negatively correlated with serum iron levels. sTfR and sTfR/log ferritin may be considered as an alternative iron marker in inflammation setting such as CKD.KEYWORDS: sTfR/log ferritin, iron status, serum iron, ferritin, chronic kidney disease, hemodialysis
The proportion and characteristics of hypertension outpatients in productive age at Selemadeg Public Health Center, Tabanan in 2020 Made Dyah Vismita Indramila Duarsa Duarsa; Hanik Nuryanti; Yenny Kandarini; Gede Wira Mahadita; Putu Aryani; Bagus Juniada
Bali Anatomy Journal Vol 3 No 2 (2020): Bali Anatomy Journal (BAJ)
Publisher : Department of Anatomy, Medical Faculty, Universitas Udayana, Bali-Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/baj.v3i2.46

Abstract

Background: Selemadeg Public Health Center (PHC) had reported, in 2018, hypertension is still included as the top 10 diseases within its community care area. The last registration data showed that mostly hypertension cases was still related to productive age population. Aims: This study aims to assess the incidence of hypertension in preventing the risk factors of hypertension. Method: This research was conducted at Selemadeg PHC, Tabanan in the period of time between February-March 2020, using a descriptive study form with a consecutive sampling technique. Results: It indicated that 33.3% from all patients had experienced hypertension. Based on gender, more in female respondents, on the rate of 41.7%. Based on the family history, it was found that 50.0% of them have had a family history of hypertension. Based on the obesity status, 55.6% with a BMI> 25. Based on high salt consumption was found 50.0% and based on low physical activity was 37,9% on smoking habits 44.4% indicated that the patient was a smoker. Conclusion: The proportion of hypertension involved productive age patients as well as it was found more in the female gender group, with a family history of hypertension, high salt consumption, smokers, obesity and has a low physical activity pattern.
Protein and Phosphate Intakes are Associated with Hyperphosphatemia in Hemodialysis Patients at Sanglah Hospital, Bali, Indonesia Made Dyah Vismita Indramila Duarsa; Yenny Kandarini; Gede Wira Mahadita; Ni Nyoman Shinta Prasista Sari
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2656

Abstract

Increased chronic kidney disease (CKD) mortality rate is significantly associated with increased blood phosphate levels. Hyperphosphatemia control is one of the main focuses in the management of hemodialysis (HD) patients. A high protein diet has been suggested to prevent malnutrition in hemodialysis patients. However, a high protein and phosphorus diet has the risk of increasing the phosphate level in the blood circulation, leading to a higher mortality rate of hemodialysis patients. This study aimed to prove that the level of protein and phosphate intake is associated with hyperphosphatemia in CKD patients with routine HD. This was cross-sectional analytical study conducted from September to October 2020 on 66 CKD patients who underwent hemodialysis. Subject characteristics and phosphorus and protein intake data were obtained from a questionnaire food recall adapted from the Food and Agriculture Organization of the United Nations. Data consumption patterns were processed using the nutritional survey software to obtain the nutritional values. Data were analyzed using the Chi-Square test to identify the relationship and risk between hyperphosphatemia and diet protein, phosphorus, and protein-phosphorus ratio. The confidence level in this study was 95%. There was a significant relationship between protein and phosphorus intake in hyperphosphatemia in CKD patients. The risk factors for hyperphosphatemia were high phosphorus intake (p=0.018; OR=3.886;95% CI: 1.212–12.460) and adequate protein intake (p=0.035; OR=3.674; 95% CI: 1.049-12.865). This study showed no significant relationship between phosphorus-protein ratio, protein-phosphorus ratio, and hyperphosphatemia incidence. In conclusion, high protein intake and excessive phosphorus intake provide a significant relationship to the incidence of hyperphosphatemia in CKD patients undergoing routine hemodialysis.
Patogenesis dan diagnosis immune reconstitution inflammatory syndrome tuberculosis Gede Wira Mahadita; I Ketut Agus Somia
Intisari Sains Medis Vol. 11 No. 3 (2020): (Available online: 1 December 2020)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1238.345 KB) | DOI: 10.15562/ism.v11i3.863

Abstract

Progressive increase in the incidence of tuberculosis (TB) and its coinfection with human immunodeficiency virus (HIV) is observed. Immune system restoration related to highly active antiretroviral therapy (HAART) can cause an immunopathologic reaction termed immune reconstitution inflammatory syndrome (IRIS)-TB. Many aspects of the IRIS phenomenon remain unraveled since its first discovery in 1954. This review is intended to summarize available evidence on various aspects of IRIS with particular focus on its pathogenesis and diagnosis. Insiden tuberkulosis (TB) dan koinfeksinya dengan infeksi human immunodeficiency virus (HIV) terus meningkat dari tahun ke tahun. Perbaikan imunitas yang berhubungan dengan highly active antiretroviral therapy (HAART) dapat disertai dengan reaksi imunopatologis yang disebut sebagai immune reconstitution inflammatory syndrome (IRIS)-TB. Perkembangan pengetahuan mengenai IRIS sejak fenomena ini pertama kali ditemukan pada tahun 1954 masih belum sempurna. Tinjauan ini bertujuan untuk merangkum literatur yang tersedia mengenai beragam aspek IRIS dengan fokus pada aspek patogenesis dan diagnosis.
Co-Authors Anak Agung Wiradewi Lestari Bagus Juniada Hanik Nuryanti I Gde Raka Widiana I Ketut Agus Somia Ketut Suega Made Dyah Vismita Indramila Duarsa Made Dyah Vismita Indramila Duarsa Duarsa Ni Nyoman Shinta Prasista Sari Putu Aryani Sianny Herawati Yenny Kandarini