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All Journal Nusantara Medical Science Journal Mandala of Health : A Scientific Journal
Haryasena Haryasena
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Dentistry Health Professions Materials Science & Nanotechnology Neuroscience Public Health

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BREAST CANCER CHEMOTHERAPY RESPONSE IN WAHIDIN SUDIROHUSODO HOSPITAL, MAKASSAR Prihantono Prihantono; Haryasena Haryasena; Daniel Sampepajung
Nusantara Medical Science Journal Volume I No. 1 Januari-Maret 2016
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v0i1.2202

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ABSTRACTIntroduction: Treatments of breast cancer are multidisciplinary. Chemotherapy isone of the most important modalities and has become the standard of breast cancertreatment of in the adjuvant or neoadjuvant setting. Evaluation is needed in order tounderstand the effectivity of the chemotherapy regiment, to improve the servicesystem and to share with other centers. Objectives: to understand thecharacteristics of chemotherapy patients, types of regimen, settings chemotherapyand neoadjuvant chemotherapy response of breast cancer. Methods: Aretrospective study was done by reviewing the administrative data of cancer patientswho were treated in the surgical oncology Wahidin Sudirohusodo Hospital, Makassarin 2014. Results: During 2014 has been carried out chemotherapy for 247 breastcancer patients, used as neoadjuvan setting 145 cases (59 %) and Adjuvan 102cases (41%). The regimen used are CAF 155 cases ( 63%), TAC 55 cases ( 22%), TA 20 cases (8%), GC 11 cases ( 5%), dan Vinoralbine 6 cases (2%).Cumulative Clinical Response are: complete response 3 cases (2%), partialresponse 112 cases (78%), stable disease 23 cases (15%), and progresive disease9 (5%). Chemoterapy response by subtype: Luminal 67%, Her2 70%, Triple Negatif88%. Conclusions: Breast cancer clinical response to various chemotherapyregimens are good, regimen and subtype affect the response to chemotherapy.Keywords: breast cancer, chemotherapy, clinical response
Original Article HUBUNGAN EKSPRESI CYCLOOXYGENASE-2 (COX-2) DENGAN DISEASE FREE SURVIVAL DAN OVERALL SURVIVAL PADA PENDERITA KANKER PAYUDARA Prihantono Prihantono; Juhamran Juhamran; Zaenal Abidin; Haryasena Haryasena; Salman Ardi Syamsu
Mandala Of Health Vol 12 No 1 (2019): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (443.883 KB) | DOI: 10.20884/1.mandala.2019.12.1.1045

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Cyclooxygenase-2 (COX-2) berperan dalam pertumbuhan tumor dan metastasisnya yang berdampak pada buruknya prognosis. Tujuan penelitian ini untuk mengetahui hubungan ekspresi COX-2 terhadap disease free survival dan overall survival pada pasien kanker payudara. Penelitian ini bersifat observasional menggunakan desain kohort dengan periode follow up selama 24 bulan. Hasil: Ekspresi COX-2 ditemukan pada 21 sampel (42%) dari 50 pasien kanker payudara. Selama follow up 24 bulan, lama DFS pada COX-2 negatif (20,1 bulan) lebih lama dibandingkan pada COX-2 positif (14,0 bulan) dan menunjukkan hubungan yang signifikan (p<0,01). Lama OS pada COX-2 negatif (22,6 bulan) lebih lama dibandingkan pada COX-2 positif (17,8 bulan) yang juga menunjukkan hubungan yang signifikan (p<0,01). Terdapat hubungan yang signifikan antara ekspresi COX-2 dengan disease free survival dan overall survival pada pasien kanker payudara. COX-2 bisa dijadikan salah satu faktor prognostik kanker payudara.
Co-Authors Daniel Sampepajung Juhamran Juhamran Prihantono Prihantono Prihantono Prihantono Salman Ardi Syamsu Zaenal Abidin