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All Journal Jurnal Gizi dan Pangan Jurnal Sains Indonesia Jurnal Sains Terapan : Wahana Informasi dan Alih Teknologi Pertanian

Martini, Rina

College Of Vocational Studies, IPB University

Author-ID : 3251740

Agriculture, Biological Sciences & Forestry Computer Science & IT Economics, Econometrics & Finance Energy Health Professions Mathematics Social Sciences Veterinary Other

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Teh putih (Camellia sinensis) dan kelor (Moringa oleifera) sebagai antihiperglikemia pada tikus Sprague dawley yang diinduksi streptozotocin Amalia Rahma; Rina Martini; Clara Meliyanti Kusharto; Evy Damayanthi; Dadan Rohdiana
Jurnal Gizi dan Pangan Vol. 12 No. 3 (2017)
Publisher : Food and Nutrition Society of Indonesia

This study aims to examine the antihyperglycemic effect of white tea (Camellia sinensis) and Moringa oleifera when administered as a single component and as mixture in streptozotocin-induced diabetic rats. The study design was experimental. The first step was to analyze epigallocathecingallat (EGCG) content as standard with High Performance Liquid Chromatography (HPLC) method. The second step was intervention in Sprague dawley rats induced by streptozotocin 40 mg/kgBW. Intervention held for 21 days with given white tea (WT), M. oleifera (MO), mixture of white tea and M. oleifera (WT+MO) and green tea (GT) as positive control with reference dose 100 mg/kgBW EGCG. Rats blood glucose and body weight were measured. The results are WT having the highest content of EGCG (4.46%). MO and WT+MO only have 2.42% and 2.46% of EGCG while GT as control is the lowest (1.29%). Measurements of blood glucose and body weight in group that given WT or MO as single component showed no significant difference with control negative group (p>0.05). Blood glucose decreased significantly in group WT+MO (p<0.05). Administration of WT+MO was able to maintain a stable body weight during the intervention period (p>0.05). The combination of white tea and M. oleifera has better ability as an antihiperglycemic agent compared to single component.

The Potential of White Tea (Camellia sinensis) and Kelor (Moringa oleifera) in Improving Lipid Profile and Histopathological Features of Pancreas in Streptozotocin-Induced Rats Rina Martini; Amalia Rahma; Clara Meliyanti Kusharto; Hadi Riyadi; Cece Sumantri; Dadan Rohdiana
Jurnal Gizi dan Pangan Vol. 14 No. 1 (2019)
Publisher : Food and Nutrition Society of Indonesia

This study aimed to examine the potential of white tea and kelor in improving lipid profile and histopathological features of the pancreas in streptozotocin-induced Sprague-Dawley rats. The research design was an experimental study with post-test control group design. Catechin content were analysed using High-Performance Liquid Chromatography. Twenty Sprague-Dawley rats (out of 24 rats, 12-week old, 200-300 g) were induced with intraperitoneal injection of streptozotocin at a dose of 40 mg/kg BW. Four groups of rats received one of the green tea (GT), white tea (WT), kelor (K), or the mixture of white tea and kelor (WTK) with a dose of epigallocatechin-3-gallate (EGCG) at 100 mg/kg BW administered orally for 21 days. Measurements of the lipid profile and preparation of histopathological features of the pancreas were performed after the intervention was completed. The results showed that white tea had the highest concentrations of catechin (39.17%), gallic acid (1.09%), EGCG (4.46%), and epicatechin (9.61%) compared to the other tea groups. The TG levels of the WTK group (95±19.35 mg/dl) were significantly different (p<0.05) from the WT and K groups but not significantly different from the normal (105.8±23.89 mg/dl), DM and GT groups. Meanwhile, the HDL levels did not show significant differences in each intervention group (p>0.05). The mean diameter of the islets of Langerhans in the DM group (9.16± 2.56 μm) was significantly different (p<0.05) from the WT (20±8.94 μm), K (17.16±5.26 μm), WTK (18.66±4.17 μm), and N (21.07±8.49 μm) groups but not significantly different from the GT group (14.33±5.24 μm). The histopathological features of the pancreas showed an increase in the diameter of the islets of Langerhans in WT, K, and WTK groups. This study revealed that the mixture of white tea and kelor had the potential to ameliorate triglyceride levels and histopathological features of the pancreas in streptozotocin-induced Sprague-Dawley rat.

Co-Authors Amalia Rahma Ani Nuraeni Annisa Rizkiriani Cece Sumantri Clara Meliyanti Kusharto Clara Meliyanti Kusharto Dadan Rohdiana Dadan Rohdiana Evy Damayanthi Firman Muhammad Basar Gilang Ayuningtyas Hadi Riyadi Ika Resmeiliana Lisya Mutiara Ramadanti Muhammad Nurmahmudi Ridwan Siskandar Sesar Husen Santosa Siti Intan Permatasari Vieta Annisa Nurhidayati Wina Yulianti

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