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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)
mimik murrukmihadi
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Medicine & Pharmacology

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PENGARUH VARIASI KONSENTRASI EKSTRAK ETANOLIK DAUN TEH HIJAU (Camelia sinensis L.) DALAM SEDIAAN KRIM TERHADAP SIFAT FISIK DAN AKTIVITAS ANTIBAKTERI nanik widyaningrum; mimik murrukmihadi; syarifatun karuniaekawati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 6 NO. 1 JUNI 2009
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (142.307 KB) | DOI: 10.31942/jiffk.v6i1.814

Abstract

ABSTRACTGreen tea is one of a herbal nature which has been proved its special virtue anti acne. Green tea leafcontains of 30-40% polifenol which is known as katekin has a characteristic as antimicroba.To make it easierto use, the extrac etanolic of green tea leaf is made in cream formulation. The purpose of this experiment is toknow variation concentration effect of green tea etanolic extract in cream formulation to the physic andantibacteria activity especially for the acne bacteria, also in spesific concentration will be find the best ofextrac etanolic green tea leaf toward physic characteristic and anti bacterial activity.In this experiment, the thick extrac of green tea leaf is obtained by maseration way of the using 50%etanol liquid. The cream is made in five formulas that is using the extrac etanolic of green tea leaf for 1%, 3%,5%, 7% and 9% concentration with the modification formula of anti acne cream. Cream is tested the physicalcharacteristic including the homogenity , isolation percent, spreading, and adhesing and also for antibacterialactivity. The data is analysed by non parametric statistical using Kruskal Wallis test continued by doing MannWhitney test with 95% of trust capacity.The result in this experiment showes that the cream of extrac etanolic form of green tea leaf in anycream concentration have good homogenity and did not isolation. As biger concentration of cream extracetanolik of green tea leaf as a smaller spreading test and adhesing test but as a biger antibacterial activitytoward Staphylococcus aureus bacterial. Cream extrac etanolik of green tea leaf as a control positive in physiccharacteristic and antibacterial activity is 7% concentration.Key words : Green tea of extract etanolic, Cream, Physic characteristic test, Bacterial activity test.
AKTIVITAS MUKOLITIK IN VITRO EKSTRAK ETANOLIK HERBA MENIRAN (Phyllanthus niruri L) TERHADAP MUKOSA USUS SAPI yulias ninik windriyati; mimik murrukmihadi; nissa ratna junita
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.716 KB) | DOI: 10.31942/jiffk.v4i1.834

Abstract

ABSTRACTPhyllanthus niruri L has been traditionally used by Indonesian people to treat cough. However, scientific basic of using this plant as mucolytic agent is still less observed. The aim of this research is to evaluate in vitro mucolytic activity of ethanol extract of P. niruri against bovine bowels mucose. In vitro mucolytic activity of P. niruri was tested through method as like as Haslinda (1999) and Setyawati (2004). Ethanol extract of P. niruri at various concentrations 0,25; 0,5; 0,75; 1,0; and 1,25% b/v mixed with mucose solution 50% b/v in fosfat buffer pH 7. The solution incubated at 37ºC during 30 minute. Solutions viscosity measured by stormer viscometer and evaluated its fluid flow properties. Negative control was mucosa solution without extract and positive control was asetilsistein. Mucolytic activity was shown by a concentration of extract which decrease viscosity of mucose solution. Ethanol extract of P. niruri had mucolytic activity againts bovine bowels mucose which decrease viscocity of mucose. However, statistically there was no difference between various concentrations of ethanol extract to mucolytic activity. Ethanol extract of P. niruri at concentrations 0,25; 0,5; and 0,75% in mucose solution had fluid flow properties thiksotropi pseudoplastic and at concentrations 1,0 and 1,25% had fluid flow properties pseudoplastic.
Co-Authors nanik widyaningrum nissa ratna junita syarifatun karuniaekawati Yulias Ninik Windriati