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All Journal Folia Medica Indonesiana JHECDs: Journal of Health Epidemiology and Communicable Diseases
Irawati Wike
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Health Professions Medicine & Pharmacology Public Health Other

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IDENTIFICATION OF ANTIRETROVIRAL MUTATION IN PROTEASE AND REVERSE TRANCRIPTASE INHIBITOR IN HUMAN IMMUNODEFICIENCY VIRUS-1 OF HIV/AIDS PATIENTS IN MIMIKA REGENCY, PAPUA Mirna Widiyanti; Eva Fitriana; Evi Iriani Natalia; Irawati Wike
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (434.509 KB) | DOI: 10.20473/fmi.v53i1.5491

Abstract

Treatment with RT Inhibitors has been used as first line program in Mimika. Regular use of antiretroviral drugs can lower the amount of the virus, but after that HIV can become resistant to the drugs given. Viral resistance to the drugs can occur because of a mutation. If the resistance-associated mutations occur in the DNA of the virus, then the ARV provided will no longer be effective. The aim of this study was to identify the presence of resistance-associated mutations in DNA fragment that encodes the protease and reverse transcriptase. This study used cross sectional design with 84 subjects who had received antiretroviral for > 6 months. The study was conducted in Mitra Masyarakat Mimika Hospital. Laboratory process included extraction, RT-PCR, electrophoresis and sequencing. Data analysis used resistance interpretation algorithms in HIV Database. Results showed that 1 subject who did not receive protease therapy was identified as having minor mutation L10V, 1 subjects receiving NRTI inhibitors had mutation M184V motive and 1 subjects with M41L motive and 1 subjects who received NNRTI inhibitor therapy identified as having mutated Y181C and V108I motive. In conclusion, mutant HIV-1 related to ARV resistance has been identified in two subjects who had received antiretroviral therapy in Mitra Masyarakat Mimika Hospital.
Pengaruh iklim terhadap Annual Parasite Incidence malaria di Kabupaten Jayapura tahun 2011 – 2018 Semuel Sandy; Irawati Wike
JHECDs: Journal of Health Epidemiology and Communicable Diseases Vol 5 No 1 (2019): JHECDs Vol. 5, No. 1, Juni 2019
Publisher : Balai Litbangkes Tanah Bumbu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.757 KB) | DOI: 10.22435/jhecds.v5i1.1031

Abstract

Penyakit malaria di kabupaten Jayapura merupakan penyakit yang endemic karena penyakit ini telah ada sejak lama dan hampir sebagian masyarakat di Kabuapten Jayapura pernah menderita penyakit malaria. letak geografis dimana banyaknya rawa-rawa dan pengaruh lingkungan seperti iklim juga berkontribusi terhadap peningkatan kasus malaria. Penelitian ini bersifat studi retrospektif, menggunakan data sekunder berupa data curah hujan, kelembapan udara, suhu, kecepatan dan arah angin dari Badan Pusat Statistik Provinsi Papua dan serta data angka Annual Parasite Incidence (API) malaria dari Dinas Kesehatan Kabupaten Jayapura selama kurun waktu tahun 2011-2016. Hasil analisis menunjukkan bahwa curah hujan, suhu, kelembaban udara dan kecepatan angin memiliki korelasi yang lemah namun tidak memiliki hubungan yang signifikan dengan angka API malaria. Kesimpulan menunjukkan bahwa kecenderungan perubahan variabel iklim tidak mempengaruhi secara langsung terjadinya peningkatan kasus malaria
Co-Authors Eva Fitriana Evi Iriani Natalia Mirna Widiyanti Semuel Sandy