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All Journal Global Medical and Health Communication Jurnal Surya Medika Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat JURNAL KEBIDANAN Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Proceeding of Bengkulu International Conference on Health
Kurnia Dewiani
Department Of Midwifery, Faculty Of Mathematics And Natural Sciences, Universitas Bengkulu, Bengkulu
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Proceeding of Bengkulu International Conference on Health

 1 
SCREENING OF SECONDARY METABOLITE PHOTOCHEMICALS EXTRACT 96% LEAF’S MAHKOTA DEWA (PHALERIA MACROCARPA) IN THE COASTAL AREA OF BENGKULU CITY, INDONESIA Kurnia Dewiani; Riana Versita; Yetti Purnama
Proceeding B-ICON Vol. 1 No. 1 (2022): Proceeding of The 2nd Bengkulu International Conference on Health (B-ICON 2022)
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/bicon.v1i1.33

Abstract

Tropical diseases are infectious diseases that occur in tropical regions. The causes of tropical diseases are various types of infections, ranging from viral, bacterial, and fungal to parasitic infections. The pharmacological treatment implemented. Further, non-pharmacological treatment is widely used, but it has side effects, and the level of danger and risk is much lower than synthetic chemical drugs. Some potential plants in Indonesia have been used for treatment, such as Mahkota Dewa (Phaleria macrocarpa). This plant helps treat microbial infections and menstrual pain, lower blood sugar, prevent the side effects of chemotherapy drugs, and lower blood pressure. The study aims to screen for the phytochemical content of secondary metabolites from the leaves of Mahkota Dewa (Phaleria macrocarpa). The method was the maceration in the BPOM laboratory and the Diploma Program of Pharmacy of The University of Bengkulu. The Mahkota Dewa (Phaleria macrocarpa) contains chemicals known as secondary metabolites. The results of the secondary metabolite screening of the leaves Mahkota Dewa (Phaleria macrocarpa) showed the presence of alkaloid compounds, flavonoids, saponins, tannins, terpenoids, saponins, and tannins. Antibacterials ingredients include flavonoids and saponins, antifungal and antibacterial, with three mechanisms: inhibiting nucleic acid synthesis, inhibiting cytoplasmic membrane function, and inhibiting energy metabolism. The flavonoid compound of the flavone class has the potential as an antibacterial with potent inhibition against Escherichia coli (gram-negative bacteria) and Bacillus subtilis (gram-positive bacteria) because it has an OH group bound to CH. The study concluded that the leaves of Mahkota Dewa (Phaleria macrocarpa) located in the coastal area of Bengkulu city are phenol, alkaloid, flavonoids, saponins, terpenoids, and tannins
TRANSDERMAL PATCH FORMULATION OF NUTMEG EXTRACT WITH HPMC (HYDROXY PROPYL METHYL CELLULOSE) AND EC ETHYL CELLULOSE (EC) AS POLYMERS Suci Rahmawati; Yetti Purnama; Kurnia Dewiani; Oky Hermansyah; Nizella Syaenri; Sari Surya Guma Sri; Elda Jumiati
Proceeding B-ICON Vol. 2 No. 1 (2023): Proceeding of The 3rd Bengkulu International Conference on Health (B-ICON 2023)
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/bicon.v2i1.160

Abstract

Nutmeg seed extract (Myristica fragrans Houtt) contains myristicin which have been an anti-inflammatory effect. Nutmeg seed extract is formulated into transdermal patch to avoid the first pass effect. This study was aimed to determine the best nutmeg extract patch transdermal formula using HPMC and EC as polymers. In this study, nutmeg extract was obtained by kinetic maceration method using 96% ethanol. The patch formula was designed into two formulas that have different types of polymer with a concentration of 4.5%, namely FP1 with HPMC polymer and FP2 with EC polymer. Patches that were evaluated for physical properties included organoleptics, weight uniformity, patch thickness, folding resistance test, drying shrinkage, absorbency test and pH. The results showed that FP1 had good organoleptic (elastic shape and even brown color); Uneven weight and thickness (SD < 0.05); Folding endurance test of 300 X; drying shrinkage 25%; absorption capacity of 8.1% and pH 6. Meanwhile, FP2 appears to have poor organoleptic properties (wrinkled shape and uneven brown color; uneven weight (SD < 0.05); uneven thickness (SD > 0.05); test folding resistance of 100 X, drying shrinkage 22.5%; absorption capacity of 20.2% and pH 6. In this study it can be concluded that FP1 with HPMC was the best formula for transdermal patch containing ethanol extract of nutmeg seeds.
Co-Authors Anggun Dineti ASMARIYAH ASMARIYAH Deni Maryani Elda Jumiati Linda Yusanti Linda Yusanti Linda Yusanti Nizella Syaenri Oky Hermansyah Riana Versita Sari Surya Guma Sri Suci Rahmawati Yetti Purnama Yetti Purnama