Article Per Year (5 Year)
p-Index From 2019 - 2024
0.23
P-Index
This Author published in this journals
All Journal Tropical Health and Medical Research Journal
Ubi Essien Isaac
Department of Human Anatomy, Faculty of Basic Medical Sciences, Cross River University of Technology, Nigeria.
Religion Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Morphological Alterations of the Rat Testicles Following Administration of Graded Doses of Leaves of Guava (Psidium guajava Linn.) Aqueous Extract Kom-Abasi Daniel Etim; Ubi Essien Isaac; Anozeng Oyono Igiri
Tropical Health and Medical Research Vol. 3 No. 1 (2021): Tropical Health and Medical Research
Publisher : Baiman Bauntung Batuah Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (456.417 KB) | DOI: 10.35916/thmr.v0i0.29

Abstract

The current study design to assess the dose-response effect of administering an aqueous extract of guava leaves on the microstructure of the testicles due to the growing use of this plant in complementary and alternative medicine practice. Twenty-four male albino Wistar rats with an average body weight of 160 g apportion to four groups (n=6 each). Group, I served as the control and received distilled water; group II gave a lower dose of 500 mg/kg body weight of guava leaf extract; group III received a medium dose of 750 mg/kg; while group IV administer a higher amount of 1000 mg/kg per day. Treatments were given once daily by gavage and lasted for 14 days, while the stock solution prepares by dissolving 50 g of the extract in 30 ml of water. The cervical dislocation method used to euthanize the rats, dissect the abdominopelvic region to obtain tissue specimens from the testes for histological processing. The outcome exhibited the extract to cause moderate to severe (dose-dependent) morphological alterations with the seminiferous tubules' fibrotic appearance, strict spermatogenic arrest, and necrosis of both the interstitial cells of Leydig and the Sertoli cells. The ingestion of guava leaves at the investigated concentration and doses is harmful to the testicle, the primary reproductive organ in males. It should therefore be consumed with caution when being used primarily in folklore-traditional medicine.
Co-Authors Anozeng Oyono Igiri Kom-Abasi Daniel Etim