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All Journal UNEJ e-Proceeding PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL ILMU KEFARMASIAN INDONESIA
Nunuk Aries Nurulita
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Education Materials Science & Nanotechnology Medicine & Pharmacology

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EFFECT OF ETHANOLIC EXTRACT OF Annona muricata L SEEDS POWDER TO DECREASE BLOOD GLUCOSE LEVEL OF WISTAR MALE RATS WITH GLUCOSE PRELOAD Rian Ulva Rizki Hasanah; Elza Sundhani; Nunuk Aries Nurulita
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Based on data from World Health Organization(WHO) diabetes mellitus was the direct cause of death of1.5 million people, more than 80% of deaths due todiabetes occurs in middle-income countries and low(WHO, 2014). According to the Basic Health Research(Riskesdas) in 2013, the incidence of diabetes mellitus inIndonesia increased by two times greater than in 2007.Annona muricata L is used as a traditionalmedicine to lower blood glucose levels with containtannin, phytosterols, calcium oxalate, alkaloids murisin(Arief and Hariana, 2006), flavonoids and essential oils(Surbakti, 1994). Flavonoid compounds have animportant role in the prevention of diabetes and itscomplications (Jack, 2012). Previous research showedthat bark of plants soursop has a most excellent efficacycompared with the roots and leaves of the Annonamuricata L in lowering blood glucose levels in male ratsinduced streptozozin (Rahmawati, 2014).This study aimed to examine the effect ofethanolic extract of Annona muricata L. seeds powder ondecreasing blood glucose level in wistar strain male ratwith glucose loading.
ANTIDIABETIC ACTIVITY OF POWDER AND ETHANOLIC EXTRACT OF ANTLION (Myrmeleon sp.) ON WISTAR STRAIN WHITE MALE RATS WITH GLUCOSE PRELOAD Hamidah Haryanti Rahma; Elza Sundhani; Nunuk Aries Nurulita
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Diabetes mellitus (DM) is a group of metabolicdiseases characterized by hyperglycemia. It occursbecause abnormalities in insulin secretion, insulinaction, or both (Gustaviani, 2006). Diabetestreatment is generally done through regular insulininjections and delivery of oral antidiabetic drug suchas sulfonylurea class, biguanide, thiazolidinedion andmeglitinida which have some side effects likeheadache, dizziness, nausea, anorexia andpermanent organ damage. More over, they are alsoexpensive. People start taking treatment intraditional way natural materials, such as antlion(Myrmeleon sp.,) to lower blood glucose level (Lee etal., 2007).Previous research showed that the young antlionmethanolic extract of had the highest inhibitoryactivity toward α-glucosidase enzyme, was 22.81%(Faiz, 2008). Giving combination of Antlion andbananas for 14 days could decrease blood glucoselevels at a dose of 0,01ml / 200g (Tyas 2006).This study has examined the antidiabetic effects ofthe powder and ethanolic extract of antlion(Myrmeleon sp.) on blood glucose level of Wistarmale rats were burdened by glucose.
Co-Authors Adzkie Muhammad Arif Budiman Arif Wirahadi Kusuma Cindy Caesaria Dwi Hartanti Elza Sundhani Fifi Rahmawati Hamidah Haryanti Rahma Imam Purnomo Sugiarto Irma Amalia Nina Nurhayati Dian Utami Rian Ulva Rizki Hasanah Tjiptasusrasa Tjiptasusrasa