Hermansyah Amir
University of Bengkulu

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UJI MICROTETRAZOLIUM (MTT) EKSTRAK METANOL DAUN Phaleria macrocarpa (Scheff.) Boerl TERHADAP SEL KANKER PAYUDARA MCF-7 Hermansyah Amir; Bambang Gonggo Murcitro
ALOTROP Vol 1, No 1 (2017)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v1i1.2711

Abstract

This study aimed to investigate research about cytotoxicity correlation level of Phaleria macrocarpa (Scheff) Boerl also known as Mahkota dewa leaves methanol extract against  MCF-7 cell in vitroto investigate the relationship between them in the goal to investigate alternative low cost herbal medicine agents to fight breast cancer. Cytotoxicity properties of samples against MCF-7 breast cancer cell lines was performed by using the Microtetrazolium (MTT) assay against MCF-7 cell line. The correlation between concentration of crude and cytotoxic activity was interpreted by statistical analyses. The study showed that P. macrocarpa leaves extracts showed cytoxicity activity against breast cancer MCF-7 cell lines which IC50 concentration showed at 15 µg/mL  Correlation between concentration of extract and cytotoxicity property (absorbance value) were founded in weak relationship (R = 0.372, R2 = 0.138).  It could be effect of many different compounds in the P. macrocarpa  leaves methanol extracts may cause the pharmacological interactions, so lower or higher concentration will be antagonistic effect on absorbance or cell viability. Further study on its mechanism pathway on revealing against breast cancer could be explored. Furthermore, the natural product derived from P. macrocarpa leaves methanol extracts have potential use as alternative drugs against breast cancer.
PERBANDINGAN HASIL BELAJAR SISWA MENGGUNAKAN MEDIA CALL CARD DAN TRUTH AND DARE Wise Meilan; Salastri Rohiat; Hermansyah Amir
ALOTROP Vol 1, No 1 (2017)
Publisher : University of Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/atp.v1i1.2715

Abstract

This study aimed to compare the learning outcomes of students with using cooperative learning type Team Games Tournament (TGT) with media Call Card and Truth and Dare in SMA Negeri 05 Bengkulu Tengah. This research is quasy experimental with population all grade students in SMA Negeri 05 Bengkulu Tengah and the sample is X3 class as experiment class 1which implement instructional media truth and dare and X1 class  as experiment class 2 which implement instructional media Call Card. Students learning outcomes in this research extend from the difference of pretest and posttest value. In the experimental class 1 average value of students learning outcomes 69,46 while the experimental class 2 at 58,21. Through a series of statistical test done hypothesis testing using t test (0,01) was obtained t =3,13 and t table =2,39. The results of data analysis showed that shere were significant differences in student learning result between the aplication of instructional media Truth and Dare with media Call Card in hydrocarbon compound material in X grade SMA Negeri 05 Bengkulu Tengah. This can be showed t test that has been done on student learning outcomes for cognitife aspect got the result that value t table < t. The obtained t = 3,133 mean while t table = 2,397.