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All Journal IJEMS (Indonesian Journal of Environmental Management and Sustainability)
Renni Yuniarti
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Agriculture, Biological Sciences & Forestry Decision Sciences, Operations Research & Management Energy Environmental Science Public Health

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Effectiveness Cream and Ointment of Spirulina platensis extract against amount of Fibroblas and Wound Area: Study on white rats whose skin is incised Bimby Irenesia; Renni Yuniarti; Endang Mahati
Indonesian Journal of Environmental Management and Sustainability Vol. 4 No. 2 (2020): June
Publisher : Research Centre of Inorganic Materials and Complexs

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.61 KB) | DOI: 10.26554/ijems.2020.4.2.39-42

Abstract

Spirulina platensishas been well-known as an abundant protein and phycocyanin. Spirulina platensis has the effect of anti-inflammatory, so it is widely used to apply cosmetics and biomedicine in the healing process of wounds. To prove that the administration of an extract ofSpirulina platensiscan increase the number of fibroblasts and accelerate the wound healing process in Wistar rats with an incision on their skin. This study used a randomizedpost-test only control group design. The skins of thirty (30) male Wistar rats were incised. This treatment was divided into 4 groups, namely the group that received the 0,1% cream (X1) of S.platensisextract, and the group that was administered with the 0,1% ointment (X2) of S.platensis extract; the negative control group was only treated by a saline solution (C1), and the positive control group was with the administration of Gentamycin 0,1% ointment (C2). The total numbers of fibroblasts were examined on day 14 and calculated using the method of tissue biopsy and hematoxylin-eosin (HE) staining. The wound was checked after 14-day Data analysis was performed with a one-wayANOVA test and was continued by Post Hoc Test LSD. The total numbers of fibroblasts on day 14 from the group of XI, X2, C1, and C2 were 15.00; 17,50; 3,83, 10,33 with p<0.001. The average size of the wounds on day 14 from the groups of X1, X2, C1, and C2 was 551,78; 435,76; 1795,95; 1193,57 with p<0.001, respectively. PostHoc Testresults on the total number of fibroblasts and extensive wound area showed significant differences between them. Administration of the 0.1% ointment of Spirulina platensisextract believed to potentially increasing the number of fibroblasts and accelerate the process of wound healing.
Effectiveness of Spirulina platensis Extract on Wound Area and TNF-a Levels on Blood: Experimental Studies In Wistar Rats Made Artificially by Vulnus Scissum and Infected by Staphylococcus aureus Olvaria Misfa; Renni Yuniarti; Yan Wisnu Prajoko
Indonesian Journal of Environmental Management and Sustainability Vol. 4 No. 2 (2020): June
Publisher : Research Centre of Inorganic Materials and Complexs

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.001 KB) | DOI: 10.26554/ijems.2020.4.2.55-58

Abstract

This research uses randomizedpost-test only control group design. Thirty-two (32) male Wistar rats with incised skin and infected with S. aureusdivided into 4 groups, namely the group given S.platensisextract at a dose of 500 mg / kgBB / day (X1) and a dose of 750 mg / kgBB / day (X2 ), the negative control group was given saline solution (C1), and the positive control group was given amoxicillin 150 mg / kg orally(C2). Wound area measurements were taken on day 14 and serum TNF-? levels were examined on day 14 using the ELISA method. Data analysis was performed with one way ANOVAtestand continued with Post Hoc Test LSD.The results showed mean size of wound closure on the 14th day in groups X1, X2, C1 and C2 is 8095.74; 6270.98;15502.69; 11475.20micrometer with p <0.001. The mean TNF-? serum levels in the 14th day of X1, X2, C1, and C2 groups were 270.75; 222.83; 1730.33; 385.75pg / ml with p <0.001. Post Hoc Test of wound area showed significant differences between groups. Post Hoc Test TNF-? levels showed significant differences between treatment groups X1 and X2 with group C1.Spirulina platensisextract 500mg / kgBB / day and 750 mg /kgBB/ day have the smallest wound area significantly and reduce TNF-? levels on blood.
Co-Authors Bimby Irenesia Endang Mahati Olvaria Misfa Yan Wisnu Prajoko