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All Journal Jurnal Kedokteran Diponegoro Universa Medicina Paediatrica Indonesiana Belitung Nursing Journal
Santoso Santoso
Department Of Biochemistry, Faculty Of Medicine, Diponegoro University, Semarang
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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THE EFFECT OF STRATIFIED DOSES OF CURRY LEAF EXTRACT (MURRAYA KOENIGII) ON TOTAL CHOLESTEROL AND TRIGLYCERIDES IN MALE SPRAGUE-DAWLEY RATS INDUCED BY HIGH FAT FEED Muhammad Iqbal Reynaldi; Santoso Santoso; Kusmiyati Tjahjono
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29256

Abstract

Background: High level of total cholesterol and tryglicerides in the blood can cause atherosclerosis. Curry leaves are often used by the society to reduce total cholesterol and trygliceride levels in the blood, but no studies have examinded the effective dosage of curry leaf extract to reduce total cholesterol and triglyceride levels.Aim: This study aims to determine the effect of giving curry leaf extract (Murraya koenigii) on cholesterol and triglyceride levels of male Sprague-Dawley rats induced by high fat feed.Methods: This study was a true experimental study with a pre-post test with randomized control group design. The subjects of the study were male Sprague-Dawley rats induced by high fat feed for 10 days. Cholesterol and triglyceride levels were measured by enymatic methods. Then, the data were analyzed using paired t test and for P3 group total cholesterol using the Wilcoxon test to analyze the differences in total cholesterol and triglyceride levels between before and after given the curry leaf extract, Repeated Anova test to analyzed the differences between groups which was then followed by post hoc bonferoni and One Way Anova to analyze the differences in total cholesterol and triglyceride levels between groups.Results: There was no significant differences in total cholesterol levels between before and after given the curry leaf extract at a dose of 200 mg/KgBW, 300 mg/KgBW, and 400 mg/KgBW (p= 0.641 for the P1 group, p= 0.385 for the P2 group and p= 0.398 for the P3 group). In contrast to triglyceride levels, there were differences in triglyceride levels before and after administration of curry leaf extrcat at a a dose of 300 mg/KgBW (p= 0.012), while the other groups were not significant.Conclusion: The stratified doses of curry leaf extract (Murraya koenigii) in this study could not reduce cholesterol level and triglyceride levelKeywords: Curry leaf extract; Dyslipidemia; Total Cholesterol; Triglyceride 
Trans fatty acids increase nitric oxide levels and pancreatic beta-cell necrosis in rats Kusmiyati Tjahjono DK; Santoso Santoso; Dwi Ngestiningsih
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.51 - 59

Abstract

BACKGROUND The prevalence of diabetes in Indonesia is increasing due to various factors, including life style changes such as trans fatty acid (TFA) intake. High TFA intake is known to be related to blood lipid profile changes resulting in cardiovascular disorders. This study was to identify the effect of TFA on nitric oxide (NO) production and on necrosis of pancreatic beta cells. METHODS A study of randomized pre-test post–test design with control group. Thirty Sprague Dawley rats were divided into 3 groups, i.e. group K (control), group P1 receiving a diet with 5% TFA, and P2 receiving 10% TFA. The intervention was performed for 8 weeks. NO level and pancreatic beta-cell necrosis were analyzed using Pearson’s chi square test. RESULTS After 4 weeks of treatment there was no change in NO levels in group K, but increased NO in P2 (2.6-3.8 ìM). At 8 weeks after treatment, NO levels in groups P1 and P2 increased to 2.6-3.4 ìM and 4.2-14.3 ìM, respectively, while in group K only 2 rats had increased NO levels of 2.8-2.9 ìM. With Pearson’s chi-square test, there was a signifant difference in the proportions of necrotic pancreatic beta cells after 4 weeks and 8 weeks (p= 0.000). No necrosis of beta cells was found in group K, mild necrosis in group P1 (1-25%) and moderate necrosis in group P2 (26-50%). CONCLUSION TFA consumption significantly increases NO levels in Sprague Dawley rats and also results in moderate grades of necrosis of pancreatic beta cells
Effect of carnitine in diphtheria: A preliminary report Soetono Soetono; Santoso Soeroso; Warsito Sutikno
Paediatrica Indonesiana Vol 39 No 3-4 (1999): March - April 1999
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2074.456 KB) | DOI: 10.14238/pi39.3-4.1999.102-7

Abstract

A double placebo controlled trial was conducted on 68 diphtheriapatients who were hospitalized in pediatric ward of Kariadi Hospital, Semarang, from 1 April 1990 to 31 March 1991. The age range of the patients was between 7 months to 13 years, with the median of 48 months and the mean of 60.5 (SD 11) months. The pretreatmentcharacteristics of both groups were similar with respect to sex, the clinical condition on admission, presence of bullneck, nutritional and immunization status. Oral camitine was administered with a dose of 100 mg/kg/ day divided into 3 doses. Other standard treatment was administered to all patients. Post-treatment comparisons were performed on the prevalence of myocarditis, CK-MB level examined on the fifth day of treatment, and mortality. It was found that the prevalence of myocarditis and CK-MB levels' were significantly less than those in the placebo group, while the mortality in the carnitine group (3%) although smaller than in placebo group (17%) was not statistically different. It seems that 1-camitine is useful to prevent diphtheritic myocarditis,while its effect on improving the overall prognosis needs further study.
Neurological Sequalae in Survivors of Perinatal Asphyxia Tjipta Bahtera; Santoso Suroso; Bambang Darmanto
Paediatrica Indonesiana Vol 32 No 7-8 (1992): July - August 1992
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (658.108 KB) | DOI: 10.14238/pi32.7-8.1992.169-77

Abstract

Perinatal asphyxia is the most common cause of either death or severely handicapped survivors. Perinatal asphyxia can be identified by one, five, ten minutes APGAR scores less than 7. Prolonged asphyxia produce hypoxemia, acidosis, hypercapnia, thus diminishing cerebral blood flow, which in turn results in clinical patterns of Hypoxic - Ischemic Encephalopathy (HIE). The atm of this study was to evaluate the accuracy of clinical observation on newborn asphyxia to predict the presence of neurological deficits connected with blood gas analysts investigation. Thirty eight newborn babies who bad APGAR scores of less than 7 as an asphyctic newborn baby group compared with an equal number of normal babies as control group. Physical and neurological examinations were performed immediately after birth and at six months of age. Two of the 38 infants who bad perinatal asphyxia died several hours after birth. Two of the 31 of the surviving infants with a historical of perinatal asphyxia bad cerebral palsy. One of the two babies with cerebral palsy bad epilepsy. Twenty nine of the 31 of the surviving infants with a history of perinatal asphyxia with or without mild HIE showed normal neurological outcomes. All of the normal newborn babies as control showed normal neurological outcome. One infant with cerebral palsy and one infant who bad cerebral palsy with epilepsy bad a history of a severe degree of HIE and moderate degree of Hm with neonatal convulsion respectively. One of the 2 infants with cerebral palsy bad severe hypoxia and none on the infants with normal neurological outcome exhibited Pa02 less than 50 mmHg. There were no significant differences ( p > 0.05) of the Pa02 PH and base deficit between the infants with a history of asphyxia and with a history of a vigorous baby, who bad a normal outcome. We concluded that postasphyxia encephalopathy was more accurate than a low APGAR score in predicting an adverse outcome, and the value of the Pa02 very important in predicting an encephalopathy.
THE REFLECTIVE SUPERVISION MODEL: AN EFFORT TO INCREASE NURSE JOB SATISFACTION Santoso Santoso; Rita Kartika Sari; Anggorowati Anggorowati
Belitung Nursing Journal Vol. 3 No. 5 (2017): September - October
Publisher : Belitung Raya Foundation, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.345 KB) | DOI: 10.33546/bnj.195

Abstract

Background: Job satisfaction influences the quality of health services in hospitals. However, low job satisfaction of nurses exists in the literature and influenced by various factors, including supervision. Thus, a reflective supervision model is considered effective in improving nurse job satisfaction. Objective: This study aims to analyze the effect of the reflective supervision model on nurse job satisfaction. Methods: This was a quasi-experimental study with control group design conducted from May to July 2017 at two hospitals at Central Java, Indonesia. There were sixty-eight nurses selected using purposive sampling, with 34 nurses assigned in the experiment and control group. Data were collected using questionnaires and then analyzed by paired t-test. Results: Paired t-test obtained p-value of 0.000, which indicated that the reflective supervision model has a significant influence to nurse work satisfaction. Conclusion: The reflective supervision model has a significant effect in increasing nurse job satisfaction. Therefore, this model could be applied by the head nurses to improve nurse outcome indicator, especially for nurse job satisfaction.
Co-Authors - Anggorowati Bambang Darmanto Djuara P Lubis Kusmiyati Tjahjono Kusmiyati Tjahjono DK Muhammad Iqbal Reynaldi Rita Kartika Sari Soetono Soetono Tjipta Bahtera Warsito Sutikno