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All Journal Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery Sriwijaya Journal of Ophthalmology Bioscientia Medicina : Journal of Biomedicine and Translational Research
Erial Bahar
Department of Anatomy, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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The Role of Serum Omega 3 Levels on Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community Welly Salutondok; Nur Riviati; Yulianto kusnadi; Erial Bahar; Nova Kuniati; Syamsu Indra
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.220

Abstract

A B S T R A C TIntroduction. Old age is related to geriatric syndrome where there are several healthproblems that often occur related to a decrease in body function and an increase inthe inflammatory process. Decrease in muscle mass, muscle strength and physicalperformance will lead to a condition of sarcopenia and frailty syndrome in the elderly.The importance of prevention so that sarcopenia does not occur in the elderly byevaluating the factors that can cause it, one of which is controlling nutritional factors(macro and micro nutrients), such as in research, namely omega-3 macronutrients.The purpose of this study was to determine the correlation between serum omega-3levels with muscle mass, muscle strength, and physical performance in the elderlycommunity at Moehammad Hoesin Hospital Palembang. Methods. This research isan observational analytic study with a cross-sectional approach which wasconducted at the Integrated Geriatric Clinic Internal Medicine RSMH Palembangfrom November 2019 to November 2020. A sample of 21 people aged> 60 years wasexamined for muscle mass, muscle strength, physical performance and omega-levels. 3 serums. All data processing and analysis in this study used SPSS version25 for Windows. Results. Of the 21 subjects, it was found that women were 19people (90.5%) and 2 men (9.5%). The mean value of muscle mass was 37.65 ± 5.7,hand grip strength was 24.04 ± 5 kg, and walking speed was 6.72 ± 1.8 seconds per6 meters. There were 11 subjects with low serum omega-3 levels of 485.25 ± 110.19mg. There was a significant relationship between serum omega-3 levels and musclemass (p = 0.041) with moderate correlation strength (r = 0.448). Conclusion: Musclemass has a significant relationship with serum omega-3 levels in the elderly withmoderate strength. Meanwhile, muscle strength and physical performance did nothave a significant relationship.
Correlation of Vitamin D Serum Levels with Muscle Mass, Muscle Strength, and Physical Performance in the Elderly Community in Mohammad Hoesin General Hospital Palembang Noveldy Calzoum Bachry; Nur Riviati; Yulianto kusnadi; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 3 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i3.225

Abstract

Background: Older people tend to have decreased activity and intake of macronutrients and micronutrients that are not in accordance with the body's needs. Research in 2017 on elderly men and women at the Center for Family Compensation (PUSAKA) in Central Jakarta showed that 80.2% of elderly people have vitamin D deficiency. Low serum levels of vitamin D in the body are the initial risk of decreased muscle mass and physical performance in old age. where there is a significant correlation between low serum vitamin D levels in the body with sarcopenia and mortality. The purpose of this study was to determine the correlation of vitamin D levels with muscle mass, muscle strength and physical performance in the elderly community at RSMH Palembang. Methods: This research is a study analytic observation with a cross-sectional approach that was carried out at the Integrated Geriatric Clinic Internal Medicine RSMH Palembang from November 2019 to November 2020. A sample of 34 people aged> 60 years were examined for muscle mass, muscle strength, physical performance and serum vitamin D levels. All processing and analysis The data in this study used SPSS version 25 for Windows. Results: From 34 subjects, it was found that there were 29 women (85.3%) and 5 men (14.7%). The mean value of muscle mass is38.76 ± 4.1 kg / m2, long runs within 6 meters 6.12± 0.9 m / sec, and hand grip strength 24.9 ± 5.2 kg. It was found that 18 (62.1%) female samples had vitamin D deficiency while 11 (37.9%) samples had vitamin D insufficiency. There was a significant correlation between muscle mass and hand grip strength with vitamin D with weak correlation strength and length of walking with vitamin D with moderate correlation strength. Conclusion: There is a significant correlation between muscle mass and grip strength and walking time of 6 meters with vitamin D.
Factors Associated with The Incidence of Infection in Tracheostomy Stoma at Mohammad Hoesin Hospital Lisa Apri Yanti; Nelly Oktriyani; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i9.349

Abstract

Introduction: Tracheostomy is a surgery to open the trachea to allow air to enter the airway. Tracheostomy cannot be separated from possible complications. Tracheostomy stoma infection is one of the complications of post-tracheostomy that occurs due to the activity of several bacteria. Many factros can cause the incidence of tracheostomy stoma infection. Objective: The aim of this study is to determine the factors associated with the incidence of tracheostomy stoma infection. Methods: Observational study with cross-sectional design. Data collection was carried out using medical record data on 71 subjects who underwent tracheostomy tube replacement from july 2019 to November 2020. Results: From 71 subjects, it was found that the subjects who had tracheostomy stoma infection were 54.9%. The results of bivariate analysis showed that age (p=0.031), comorbidities (p=0.009), the type of tracheostomy tube (p=0.015), the use of antiseptic in tracheostomy dressing (p=0.020), tracheostomy tube care (p=0.013), and the interval of changing the tracheostomy tube (p=0.041) are the significant factors. The results of multivariate analysis showed that tracheostomy tube care and the interval of changing the tracheostomy tube had a significant effect on tracheostomy stoma infection. Tracheostomy tube care has a risk of 9.362 times to experience infection with CI95%(1.535-57.086) and the interval of changing the tracheostomy tube has a risk of 10.669 with CI95% (1.074-105.985). Conclusion: There is a significant relationship between age, comorbidities, type of tracheostomy tube, the use of antiseptic in tracheosotmy dressing, tracheosotmy tube care, and interval of changing the tracheostomy tube with the incidence of tracheostomy stoma infection.
Factors Affecting Intratympanic Corticosteroids Injection Therapy Results in Sudden Deafness Patients at Dr Mohammad Hoesin Hospital Palembang Abla Ghanie; Listya Paramita; Fiona Widyasari; Ahmad Hifni; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.364

Abstract

Background. Sudden deafness is an emergency in the Ear Nose Throat Department, a subset of sensorineural hearing loss within a 72-hour window period and consists of a decrease in hearing of 30 decibels affecting at least three consecutive frequencies. The therapy given is corticosteroids, systemic corticosteroids or intratympanic corticosteroids injection, or both. The prognosis of sudden deafness depends on several factors. Patient with sudden hearing loss does not always have the same result in hearing improvement. This study was aimed to determine the factors that affect the results of intratympanic corticosteroid injection therapy in patients with sudden deafness.Methods. This study is an observational study with a cross-sectional design. The data were collected using medical records on 96 ears given intratympanic corticosteroid injection therapy at Dr. Mohammad Hoesin Hospital Palembang from July 2018 to February 2021.Results. From 96 ears conducted in the study, the improvement of therapeutic results on intratympanic corticosteroid injection in patients with sudden deafness was 72.9%. The study found factors that influenced the outcome of therapy, namely age (p=0.002), the onset of therapy (p = 0.003), and the use of a combination of systemic steroids (p=0.010). From the logistic regression test, it was found that the factors that most influenced the results of intratympanic corticosteroid injection therapy were young age 18-40 years (p=0.016) with (OR) 6.654 (CI95% 1.418-31.222) and therapy onset less than two weeks (p=0.027) with (OR) 3.108 (95% CI 1.134-8.515).Conclusions. The factors associated with the improvement in the outcome of intratympanic corticosteroid injection therapy in patients with sudden hearing loss were patient age and early onset of therapy.
Comparison of Omega-3 Serum Level Between Hiv-Aids Patients Along with Their Clinical Profiles and Healthy Population in Mohammad Hoesin General Hospital Palembang Lidiawati Handayani; Harun Hudari; Eddy Mart Salim; Erial Bahar; Nova Kurniati; Zulkhair Ali; Ferry Usnizar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 12 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.382

Abstract

Introduction. Human Immunodeficiency Virus (HIV) infection has been a concerning health problem worldwide. It causes reduction in body immune system and inflammation that can affect its clinical profile. Undergoing ARV therapy patients causes intestine microbiota dysbiosis and translocation that lead to imperfect absorbtion of fatty acid. One way to control microbiota dysbiosis is by controlling the nutritional factor, especially with omega-3. However, different regions upstands different custom in fish consumption especially those of which are rich in omega-3. The purpose of this research is to compare omega-3 serum level between HIV-AIDS patients and healthy population, as well as analyzing the correlation of omega-3 serum level with of HIV-AIDS patient clinical profile.Methods. The research will be applying observational analytic study using comparative study approach which will be performed in Tropical Infection Internal Medicine polyclinic and Medical Check-Up Polyclinic in RSMH Palembang starting from April 2020 until January 2021. Sample consisted of 32 HIV-AIDS patients from 20-58 years of age and 16 healthy population from 27-35 years of age on whom will be performed physical examination as well as clinical profile and omega-3 serum level examination. All data processing and analysis will be performed using SPSS v.25 for windows.Results. Out of 32 HIV-AIDS patients, we obtained low omega-3 serum level with median value at 3 (2-4) Umol/L, while in healthy population was 4 (3-6) Umol/L. Multivariate analysis inferred that the lower omega-3 serum level correlated with HIV-AIDS stage, duration of ARV therapy, blood pressure, and sex.Conclusion. Omega-3 serum levels in HIV-AIDS patients were lower than the healthy population. There was a correlation between omega-3 serum levels and their clinical profile of HIV-AIDS patients in Mohammad Hoesin General Hospital Palembang.
Correlation between Intraoperative Ossicular Status and Conductive Hearing Loss Degree among Chronic Suppurative Otitis Media Patients in Dr Mohammad Hoesin General Hospital Palembang Rizandiny; Ahmad Hifni; Erial Bahar; Abla Ghanie
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.409

Abstract

Background: Chronic suppurative otitis media (CSOM) is a chronic inflammation of the mucosa and periosteum of the middle ear and mastoid cavity that defined as a perforated tympanic membrane with persistent drainage for more than 2 months. Preoperative hearing threshold and air bone gap (ABG) assessment are expected to predict the ossicular status which can only be ascertained intraoperatively. This study aimed to determine the correlation between intra-operative ossicular status and the degree of conductive hearing loss assessed based on the hearing threshold and average ABG among CSOM patients in RSUP Dr. Mohammad Hoesin Palembang. Methods: Observational research using a cross sectional design. The data were collected using medical record on 64 subjects with a diagnosis of CSOM who underwent mastoidectomy surgery at Dr. Mohammad Hoesin Hospital Palembang for the period of March 2019 to June 2021. Results: From 64 samples conducted in the study, the average ossicular status score in CSOM patients was 1.84 ± 1.48, with the highest group scoring 0 being the malleus incus and intact stapes as many as 21 patients (31.3%). There was a strong positive correlation between hearing threshold scores and intra-operative ossicular status scores (p<0.005, R=0.5) and there was a strong positive correlation between ABG scores and intra-operative ossicular status scores (p <0.005, R=0.6). From the linear regression test, the most influential in predicting intra-operative ossicular status scores were gender, hearing threshold value, ABG value, and the presence of cholesteatoma Conclusions: There is a significant relationship between intra-operative ossicular status and the degree of conductive hearing loss in CSOM patients.
Accuracy of Cell-Free DNA (cfDNA) in Colorectal Cancer Diagnosis Anjab Akmal Sya’roni; Suyata; Imam Supriyanto; Vidi Orba Busro; Ayus Astoni; Mediarty Shahrir; Taufik Indrajaya; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 11 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i11.422

Abstract

Background: Colorectal cancer is the third most common type of cancer following lung and breast cancer with the second most common cause of cancer-related death globally. Delayed diagnosis due to limited source and modality to perform early diagnosis lead to advanced-stage condition which contributes to higher morbidities and mortalities. Recent diagnosis of colorectal cancer depends on biopsy of suspected tissues, either obtained surgically or per colonoscopy. Colorectal cancer detection through cell-free DNA measurement allowing small-size cancer being detected even in early stage. cfDNA originated from derivates of increased and abnormality apoptosis-necrosis pathway from cancer lesion, therefore can be managed as specific tumor marker. Methods: Diagnostic test was performed at the Gastroentero Hepatology Outpatient Unit and Internal Medicine Inpatient Unit of Dr. Mohammad Hoesin General Hospital Palembang from March to June 2021. Data processing and analysis using SPSS version 26.0 for Windows. Results: Among 50 subjects included, 39 subjects (78%) are diagnosed with colorectal cancer, whereas 11 subjects (22%) as control. The median of cfDNA result is 59,71 ng/mL with 92,3% sensitivity, 90,9% specificity, 95,2% positive predictive value, 82,3% negative predictive value, and 92,4% accuracy rate. Combination the measurement of cfDNA, CEA, and CA19-9 appears to have better AUC instead of single measurement. Conclusion: The study reveals that cell-free DNA (cfDNA) demonstrated a very promising accuracy rate in diagnosing colorectal cancer.
Correlation of Voice Handicap Index 10 with Reflux Symptom Index and Reflux Finding Score in Patients with Dysphonia Ari Utama; Lisa Apri Yanti; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.508

Abstract

Background. Voice disturbance occurs when the quality, pitch, loudness, or flexibility of other people's voices differ according to age, gender, and similar cultural groups. The Voice Handicap Index (VHI) is one of the most widely used tools worldwide to measure the physical, functional, and emotional aspects of voice disorders. This study aims to determine the correlation of voice handicap index-10 with reflux symptom index and reflux finding scores in patients with dysphonia complaints at Dr. Mohammad Hoesin General Hospital Palembang. Methods. This study is a cross-sectional study using a correlation test design that aims to determine the correlation between VHI-10 and RSI and RFS in patients with dysphonia complaints. Results. The sample of this study includes the demographic factors of the research subjects, namely age, gender, and occupation. This study shows that patients with RFS ≥ 7 affect the VHI-10 score ≥ 11 with a proportion of 72%. Conclusion. There is a moderate positive correlation between the RFS score and the VHI-10 score, where the higher the RFS value, the higher the VHI-10 score in patients with dysphonic complaints.
The Comparison of p16 Protein Expression between Single and Multiple Seborrheic Keratosis Indri Widya Sari; Yulia Farida Yahya; Suroso Adi Nugroho; Erial Bahar; Ika Kartika
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.510

Abstract

Background. Seborrheic keratosis (SK) is a benign epithelial tumor that attacks adults, the elderly, and an increasing number of age-related lesions. Various risk factors influence the pathogenesis of SK, including genetic predisposition and sun exposure. Recently, SK associated with a theory of keratinocytes aging. The aging prevents unlimited and uncontrolled growth of damaged cells, thereby preventing degeneration, but on the other hand, increases the resistance of the cells to apoptosis. From previous studies, the expression of p16 protein increased substantially with age, thus enabling it to be a biomarker of cellular aging at the molecular level. This study was aimed to determine p16 protein expression between single and multiple seborrheic keratoses, the relationship between p16 protein expression in single and multiple SK, and p16 protein expression in the elderly. Methods. Observational study with a cross-sectional design was used to determine the comparison of p16 protein expression between single and multiple seborrheic keratoses was conducted from December 1, 2021, to January 31, 2022. According to the inclusion criteria, study participants with a total of 42 people were selected through the consecutive sampling method. Physical examinations, dermoscopic and histopathologic were carried out until the results were obtained. Then the data were analyzed using the Fisher Test, Chi-Square, with a 95% confidence interval (p <0.05). Results. Most SK patients were found in the age range of 60-69 years (38%), male gender (54.8%), sun-related occasional 3-6 hour per day (50%), location of SK in sun-exposed areas (83.3%), the number of multiple lesions (69%), size 1-2 cm (57.1%), disease duration > 3 years (54.8%), and have no comorbid (69%), an acanthotic subtype of SK (40.5%). All single SK patients have a negative-weak expression of p16 protein (38.2%). Multiple SK patients have a moderate-strong expression of p16 protein (100%) and negative-weak expression of p16 protein (61.8%). Based on statistical analysis using Fisher Exact test has a statistically significant to p16 protein expression with number SK lesion (p-value 0,043). Conclusion. There is a significant correlation between p16 protein expression with single and multiple SK. The study has several limitations. The sample size was small. Other supporting examinations are needed in SK, including polymerase chain reaction (PCR).
Correlation of Interleukin-6 Levels with Clinical Features and Chest X-Ray Imaging in Coronavirus Disease-19 (COVID-19) Patients at Dr. Mohammad Hoesin General Hospital Palembang Raden Yudistira Dwi Ananda; Nova Kurniati; Harun Hudari; Erial Bahar
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 5 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i5.515

Abstract

Background. COVID-19 infection, both moderate and severe symptoms can cause pneumonia that can be detected on a chest X-ray. Along with the increasing severity of the clinical picture of COVID 19, it can also trigger a cytokine storm, one of which is an increase in Interleukin-6 levels. This study was conducted to see the correlation between IL-6 levels with clinical features and chest radiographs in patients with COVID-19 Methods. This research is a cross-sectional study using an observational analytic. The samples in this study were confirmed COVID-19 patients who were being treated at Dr. Mohammad Hoesin General Hospital, Palembang. A history and physical examination were performed to determine the clinical picture as well as a chest X-ray and IL-6 levels. Results. There were 31 samples of COVID 19 patients. High levels of IL-6 were found in 26 (83.9%) samples. The clinical picture of the patient was dominated by dyspnea as much as 19 (61.3%), fever 16 (5.6%), low O2 saturation 12 (38.4%) and a chest X-ray of pneumonia 26 (83.9%). There was a significant relationship (P<0.05) between IL-6 levels with clinical features and chest X-rays. The R-value on the thorax with pneumonia (0.692), lesion area (0.711) and clinical features with temperature (0.906), respiratory rate (0.706) indicated a strong correlation, while O2 (-0.732) indicated a strong negative correlation. Conclusion. There is a significantly strong correlation between Interleukin 6 levels with clinical features and chest X-rays in patients with COVID-19.
Co-Authors Abdur Rahman Abla Ghanie Abla Ghanie, Abla Adi Mulya Afriza Rizqi Zaini Ahmad Hifni Ahmad Hifni Ahmad Hifni Ahmad Rasyid Amir Hamzah Anang Tribowo Anggi Ciptawan Anjab Akmal Sya’roni Apriandini Mirdasari Putri Argo Ismoyo Ari Utama Ayus Astoni Ditta Puspa Anggraini Eddy Mart Salim Eddy Mart Salim Eddy Mart Salim Edwin Nugraha Fitriawan Ferry Usnizar Fiona Widyasari Fredi Heru Irwanto Harun Hudari Hidayatullah Ika Kartika Imam Supriyanto Imaniar Kesuma Indri Widya Sari Ismail Bastoni Lidiawati Handayani Lisa Apri Yanti Lisa Apri Yanti Lisa Apri Yanti Listya Paramita M. Aprizal Putera Mariance Mayang Indah Lestari Mediarty Mufida Muzakkie Mulawan Umar Mulawan Umar Nelly Oktriyani Norman Djamaludin Nova Kuniati Nova Kurniati Nova Kurniati Noveldy Calzoum Bachry Nur Riviati Nurmalia Purnama Sari Okta Kurniawan Saputra Petty Purwanita Phey Liana Puspa Zuleika Puspa Zuleika, Puspa Raden Yudistira Dwi Ananda Rama Mandela Riezki Indrina Pratiwi Rizandiny SNA Ratna Sari Devi Suroso Adi Nugroho Suyata Syamsu Indra Syamsu Indra Syamsu Indra Taufik Indrajaya Trijoso Permono Vidi Orba Busro Welly Salutondok Yulia Farida Yahya Yulia Nugraha Karsita Yulianto kusnadi Yuniza Yuniza Zen Ahmad Zulkhair Ali