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All Journal Jurnal Kesehatan Andalas Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kreativitas PKM Majalah Kedokteran Andalas Bioscientia Medicina : Journal of Biomedicine and Translational Research Ina Kidney Human Care Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Multidisciplinary Science Eduvest - Journal of Universal Studies
Harun Harnavi
Fakultas Kedokteran Universitas Andalas
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Journal : Ina Kidney

 1 
The Role of Methylglyoxal Accumulation on Cognitive Function Impairment of Chronic Hemodialysis Patients: an Observational Study Harnavi Harun; Roslaini Roslaini; Syaiful Azmi; Rose Dinda Martini
Indonesian Journal of Kidney and Hypertension Vol 2 No 1 (2019): January - April 2019
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.665 KB)

Abstract

Background: Cognitive function decline is prevalent on routine hemodialysis patients. Many factors contribute to the increased risk of cognitive function impairment, one of them is the accumulation of uremic toxins. Methylglyoxal (MG) has been identified as one of the uremic toxins found in dialysis patients by the European Uremic Toxin Group. It has also been found much higher on CKD patients; over five times higher in non-dialysis CKD and 18-40 times higher in CKD patients on dialysis, and cause impaired cognitive function in rats with diabetes. Aim: To find the correlation between blood MG levels and cognitive function of patients who underwent routine hemodialysis. Methods: This study is an observational cross-sectional study done in Hemodialysis Unit of Dr. M Djamil General Hospital, Padang, West Sumatera, Indonesia. Fifty-seven subjects aged 40-60 years old were included in this study, where the blood MG levels were obtained. Cognitive function was measured using the Mini Mental State Examination (MMSE) questionnaire. Result: Among 57 subjects, 29 (50.8%) were male, and 33 (57.9%) were 50-60 years old. The subjects’ mean methylglyoxal levels were 10.8 (SD ± 3.2) µmol/L. The subjects’ mean MMSE score was 26 (SD ± 1.8), with 35% of the subjects had low (<25) scores. Spearman correlation analysis showed a statistically significant negative correlation between methylglyoxal level and MMSE score (r = -0.6, p >< 0.001). Conclusion: High levels of methylglyoxal negatively correlates with cognitive function in chronic hemodialysis patients. Future research should include analysis regarding age, gender, hypertension, and other confounding factors.
Correlation between Urinary Cyclophilin A and Urinary Albumin Levels on Diabetic Kidney Disease Harnavi Harun; Rangga Lunesia; Syaiful Azmi
Indonesian Journal of Kidney and Hypertension Vol 2 No 2 (2019): May - August 2019
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (426.245 KB) | DOI: 10.32867/inakidney.v2i2.29

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Introduction: Diabetic kidney disease (DKD) is a complication of diabetes mellitus characterized by albuminuria persisting within 3 to 6 months, the earliest clinical evidence is microalbuminuria (30-299 mg/24hours or 20-199 ug/i). Cyclophilin A (Cyp A) is an 18 k-Da 165-amino acid long cytosolic protein also known as peptidylprolyl isomerase A. In DN, hyperglycemia will cause Cyp A secretion by human kidney-2 (HK-2) cells from PTEC and mesangial-13 cells (MES-13) and causes kidney damage. Material and Methods: This study was an analytic observational, cross sectional study conducted at the clinic and inpatient internal medicine installation at dr. M. Djamil General Hospital Padang for 6 months. Samples were selected by consecutive sampling, as many as 60 people with post prandial blood glucose > 180 mg/dl and urinary albumin > 30 mg/24 hours and met the inclusion and exclusion criteria. The samples were examined for urinary Cyp A and albumin levels. Results: The mean level of urinary Cyp A in patients with DKD is 4.96 (2.03) ng/ml. Median urinary albumin levels in DKD patients is 287.89 (30.79-394.57) mg/24 hours. Correlation analysis between urinary Cyp A and albumin levels showed a significant (p < 0.05) with a positive and strong correlation (r = 0.776) in DKD patients. Conclusion: There was an increase of urinary Cyp A and urinary albumin levels, with a positive and strong correlation between them in DKD patients. Keywords: Urinary Cyclophilin A, urinary albumin, diabetic kidney disease
Plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Creatinine Levels after Percutaneous Coronary Intervention Radias Zasra; Harnavi Harun; Syaiful Azmi; Yerizal Karani
Indonesian Journal of Kidney and Hypertension Vol 2 No 3 (2019): September - December 2019
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (361.373 KB) | DOI: 10.32867/inakidney.v2i3.31

Abstract

Abstract Background. Contrast-induced nephropathy (CIN) is defined as an increase in serum creatinine ≥ 25% or ≥0.3 mg/dl in 48 hours after the administration of a contrast agent in the absence of other causative factors (KDIGO 2012). Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a substance produced by the kidneys in acute kidney injury (AKI) caused by various insults from ischemia to toxin-induced nephropathy. NGAL is known to increase earlier than serum creatinine level. NGAL is also a protease-resistant polypetide; it is released from the distal tubule, secreted to the urine or returned to the plasma (back leak), freely filtered in the glomerulus, reabsorbed in the proximal tubule through the megalin receptor endocytosis or secreted to urine. This makes NGAL detectable both in the blood and urine. Aim. To elucidate the effect of contrast administration to serum NGAL and serum creatinine levels with in patients undergoing PCI. Methods. The study was done in the Cardiovascular Care ward in M. Djamil General Hospital, Padang, West Sumatra, Indonesia. Through consecutive random sampling, 21 subjects were selected. The subjects’ serum NGAL and creatinine levels were acquired before PCI and 6 hours after contrast administration. Results. The mean serum NGAL and creatinine levels of the subjects before and after contrast administration were 52.26 ng/ml vs 64.78 ng/ml and 1.1 mg/dl vs 1.09 mg/dl, respectively. The serum NGAL level difference before and after contrast administration was statistically significant (p=0.003) whereas the serum creatinine level was not (p>0.005). Conclusion. There is an increase of serum NGAL levels before and after contrast administration in patient undergoing PCI, whereas serum creatinine level was not. Future studies should elaborate on the use of NGAL as an early diagnostic marker for CIN.
Co-Authors Abdul Alim Rahimi Afdhol Falah Ajat Sudrajat Alexander Kam Alexander Kam Alexander Kam Andikha Putra Annesa Fadella ayu pathya Deddy Canceria Suka Rahmatsyah Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Deka Viotra Dela Hangri Jalmas Dian Puspita Diana Melida Dional Setiawan Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Drajad Priyono Evelin Veronike Fauzar Fauzar Fauzar Febrianti Ika Kurnia Genta Pradana gina ariani Jersivindo Ranazeri Kam Alexander Khairat AS Radias Zasra Radias Zasra Rangga Lunesia Rezki Sadeli Rinita Amelia Rizkianto Imannual Rose Dinda Martini Roslaini Roslaini Roza Kurniati Roza Kurniati Roza Kurniati Roza Mulyana Ruhsyahadati Ruhsyahadati Sjaaf Fidiariani Syaiful Azmi Syaiful Azmi Syaiful Azmi Syaiful Azmi Vesri Yoga Yerizal Karani Yudha E. Pratama Yulistia Asmi Yusti Siana Zaki Mahmudi Dasril Zaki Mahmudi Dasril