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All Journal Indonesian Journal of Cardiology Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Harris Hasan
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Resolution of ST-Segment Depression In Reciprocal Leads As Predictor Mayor Adverse Cardiac Event For ST-Segment Elevation Myocardial Infarction With Fibrinolytic Therapy Aldino Satria Adhitya; Andika Sitepu; Zulfikri Mukhtar; Harris Hasan
Jurnal Kardiologi Indonesia Vol 39 No 2 (2018): Indonesian Journal of Cardiology: April-June 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i2.735

Abstract

Background: ST Elevation Myocardial Infarction (STEMI) may cause Major Cardiovascular Event (MACE). Revascularization needs to be done in all STEMI patients to restore coronary blood flow, hence saving myocardial perfusion. ST Segment Depression (STSD) in reciprocal ECG lead is associated with poor prognosis in STEMI patients receiving fibrinolytic therapy. The main purpose of this study is to evaluate MACE in STEMI patients receiving fibrinolytic therapy using resolution in STSD. Methods: This cohort prospective study with 60 subjects of STEMI patients which are evaluated for MACE (death, heart failure, and rehospitalization) within 30 days after myocardial infarction. Resolution in STSD is defined as resolution ≥ 50% STSD in reciprocal leads within 90 minutes after fibrinolytic therapy.Results: Bivariate analysis showed that Ejection fraction (EF) <40% with OR 8,32 (2,11-32,74), p=0,001; smoking with OR 4,17 (1,05-16,57), p=0,034; Anterior STEMI with OR 3,94 (1,11-13,90), p= 0,027; Creatinine > 1,97 mg/dl with OR 3,69 (1,18-11,55), p= 0,022; complete outpatient medication with OR 5,23 (1,61-17,01), p= 0,004; fragmented QRS with OR 5,23 (1,61-17,01), p= 0,001; resolution in STSD with OR 26,35 (5,16-134, 40), p=<0,001; resolution in ST Segment Elevation with OR 10,5 (2,97-37,24), p=<0,001; are proven to be determining factor for MACE within 30 days. Multivariate analysis showed that among those determining factors for MACE, resolution in STSD on reciprocal leads is evidently the most dominant factor for predicting MACE within 30 days in STEMI patients receiving fibrinolytic therapy [OR 11.47 (1.14-115.10), p=0.038].Conclusion: There is significant difference in MACE within 30 days after myocardial infarction (MI) between patients with and without resolution in STSD. The subjects without resolution in STSD showed higher MACE incidence. Resolution in STSD is evidently an independent predictor for MACE within 30 days after myocardial infarction in STEMI patients.Keywords: Resolution in STSD, MACE, STEMI, Fibrinolytic
Value of Fragmented QRS Complex on 12-lead ECG as A Valuable Marker of Myocardial Damage of CAD Patients andrico tobing; Anggia Chairuddin Lubis; Edison Bun; Harris Hasan
Jurnal Kardiologi Indonesia Vol 40 No 2 (2019): Indonesian Journal of Cardiology: April-June 2019
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v40i2.736

Abstract

Background: Presence of Fragmented QRS (fQRS) on a 12-lead Electrocardiogram (ECG) was associated with various cardiac diseases. This phenomenon could represent as an electrical disruption of conduction system following myocardial damage due to coronary artery disease (CAD). We aimed to investigate the value of fQRS to detect the myocardial scar as detected by SPECT Myocardial Perfusion Imaging (MPI). Methods: A cross-sectional study of patients with clinical diagnosis of CAD who underwent Cardiac SPECT. The fQRS defined as morphologies of QRS wave (<120 ms), which included an additional R wave (R’), notching in the nadir of S wave, or >1 R’ (fragmentation) in 2 contiguous leads, corresponding to a major coronary artery territory. Pathological Q wave, paced rhythm, typical right or left bundle branch block pattern with QRS duration of ≥ 120 ms were excluded. MPI was interpreted by visual analysis and semi-quantitative scores on 17-segment assessment according to standard nomenclature. Results: Total of 72 patients (49 males, mean age 54.7 ± 9.8 years). fQRS was found in 46 patients (64%). The frequency of myocardial scar was significantly higher in patients with fQRS (89% vs. 15%, p<0.05). Sensitivity, specificity, positive and negative predictive value of fQRS for any of myocardial scar as detected by SPECT analysis were 91%, 81%, 89%, and 84%, respectively. From regional scar analysis, fQRS has sensitivity and specificity of 87% and 90% for anterior wall, 76% and 80% for inferior wall, 73% and 79% for lateral wall. LVEF was significantly lower in patients with fQRS (36.9±2.1 vs. 53.2±2.2, p< 0.05). Conclusion: The fragmented QRS could serve as a novel ECG marker to detect and localize the myocardial damage in CAD patients. Regional fQRS patterns denote the presence of regional myocardial scar and are a valuable diagnostic marker of CAD with good sensitivity and specificity. Keywords: fragmented QRS, SPECT
Nilai Skor CHA2DS2-VAS-HSF Sebagai Prediktor Kejadian Nefropati Yang Diinduksi Kontras Pada Pasien Sindroma Koroner Akut Yang Menjalani Prosedur Intervensi Koroner Perkutan Herman William Parlindungan; Refli Hasan; Cut Aryla Andra; Nizam Zikri Akbar; Ali Nafiah Nasution; Harris Hasan; Zainal Safri; Anggia C Lubis; Bertha Gabriella Napitupulu
Jurnal Kardiologi Indonesia Vol 39 No 2 (2018): Indonesian Journal of Cardiology: April-June 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i2.766

Abstract

Background: Contrast-Induced Nephropathy (CIN) is a serious problem that can be found in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). The development of CIN in hospitalized patients even with coronary revascularization can immediately increase morbidity and mortality both during treatment and long-term outcomes. In a recent study, a CHA2DS2-VASC-HSF score was reported to predict coronary artery severity and major cardiovascular events (MACE) as well as CIN in AMI patients without atrial fibrillation. The purpose of this study was to investigate the CHA2DS2-VASC score as a predictor of CIN in AMI patients undergoing PCI procedures. Methods: This study was an ambispective cohort study of 53 AMI patients who were treated at cardiac care and underwent PCI procedures. The CHA2DS2-VASC-HSF score was calculated for each patient. From this study found 14 cases (26.4%) with a total CIN prevalence of 16.83%. CIN is defined as an increase in serum creatinine> 0.5 mg / dL or an increase in serum creatinine> 25% from baseline within 24 hours post PCI. Results: Through the analysis of the ROC curve, we established the CHA2DS2- VASC-HSF score cut point> 5 as a predictor of CIN with a sensitivity of 78.57% and specificity of 66.6 %% (AUC 0.818, 95%: CI 3.018-6.142, p <0.001). By getting the equation from the linear regression assessment we also found the probability of the occurrence of CIN in accordance with the CHA2DS2-VASC-HSF score. Conclusion: CHA2DS2-VASC score has a positive correlation with CIN. Therefore, this score can be used as a simple scoring system and can predict the incidence of CIN in AMI patients undergoing PCI procedures.
A Significant Addition of Left Ventricular Fractional Shortening to Ejection Fraction correlated with Global Longitudinal Strain Value in Predicting Major Acute Cardiovascular Event in patients with Acute Coronary Syndrome Bertha Gabriela Napitupulu; Harris Hasan; Nizam Z Akbar; Andre Pasha Ketaren; Zainal Zafri; Ali Nafiah Nasution
Jurnal Kardiologi Indonesia Vol 41 No 4 (2020): Indonesian Journal of Cardiology: October - December 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1069

Abstract

Background: Global longitudinal strain (GLS) was a proven predictor of systolic function improvement and myocardial remodeling after acute coronary syndrome (ACS) for a residual left ventricular function defined their prognosis. However, not all echocardiography devices are equipped by speckle tracking (STE) as compare to the availability of M-mode modality which capable on assessing fractional shortening (FS) instead. Methods: This study evaluated clinical and echocardiography parameters on myocardial infarction (MI) and non-MI ACS patients. Clinical outcome was defined as composite major acute cardiovascular event (MACE) on 6 months of follow up. Results: Over 145 patients, GLS>-9.4% was found to be an independent predictor of MACE despite of troponin, age, ejection fraction (EF), prior reperfusion and infarct location [(HR 5.89 (1.82-16.51)]. There is negative correlation between FS and GLS (Spearman r -0,717; p<0,01). By using logistic regression analyses, it was found that the addition of FS<25% to biplane Simpson EF<50% could be useful to rule in the presence of GLS>-9.4% (AUC 0.831). Conclusion: GLS had a prognostic value in patients with ACS. Left ventricular conventional M-mode FS in addition to Simpson EF were well correlated with GLS as well they can be considered as an alternative in predicting the incident of MACE in patient with ACS. Keywords: global longitudinal strain, prognostic, fractional shortening, acute coronary syndrome
APO B/APO A-I RATIO IN PATIENTS WITH STENOSIS CORONARY HEART DISEASE GREATER OR LESS THAN 70% Dedi Ansyari; Tapisari Tambunan; Harris Hasan
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1198

Abstract

Penyakit kardiovaskular adalah salah satu penyebab terbesar kematian di dunia, termasuk di Indonesia. Salah satunya adalahpenyakit jantung koroner yang disebabkan adanya aterosklerosis. Perlu adanya petanda pengganti proses aterosklerosis sebagai faktorkebahayaan dan sebagai peramal aterosklerosis dan PJK. Apo B dan rasio Apo B/Apo A-I dianggap sebagai petanda yang terbaik. Tujuanpenelitian untuk mengetahui rasio Apo B/Apo A-I di pasien PJK dengan stenosis lebih besar atau sama dengan 70% dan lebih kecil 70%.Metode penelitian dengan potong lintang di 69 pasien PJK, yaitu 46 pasien PJK dengan stenosis lebih besar atau sama dengan 70% dan23 pasien PJK dengan stenosis lebih kecil 70% di Departemen Kardiologi FK. USU/RSUP H. Adam Malik Medan bekerja sama denganDepartemen Patologi Klinik FK. USU/RSUP. H Adam Malik Medan masa waktu Juli 2015 sampai dengan November 2015. Hasil telitiandidapatkan kadar Apo B di pasien PJK dengan stenosis lebih besar atau sama dengan 70% adalah 115,63±30,96 dan pasien PJK denganstenosis lebih kecil 70% adalah 96,43±25,62 dengan nilai p=0,013. Kadar Apo A-I di pasien PJK dengan stenosis lebih besar atau samadengan 70% adalah 148,30±26,80 dan pasien PJK dengan stenosis lebih kecil 70% adalah 173,74±32,33 dengan nilai p=0,001. RasioApo B/Apo A-I di pasien PJK dengan stenosis lebih besar atau sama dengan 70% adalah 0,79±0,20, rasio Apo B/Apo A-I di pasienPJK dengan stenosis lebih kecil 70% adalah 0,55±0,14 dengan nilai p=0,0001. Dari hasil telitian dapat disimpulkan, bahwa terdapatperbedaan bermakna kadar Apo B, Apo A-I serta rasio Apo B/Apo A-I di pasien PJK dengan stenosis lebih besar atau sama dengan 70%dan pasien PJK dengan stenosis lebih kecil 70%.
The Level of Knowledge of the Community About Heart Health in The Covid-19 Pandemic Era Harris Hasan; Raynaldo, Abdul Halim
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 4 No. 2 (2022): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v4i2.9126

Abstract

Background: Cardiovascular disease is still a global health problem. Data obtained from the World Health Organization (WHO) states that the death rate from cardiovascular disease (CVD) is 17.7 million people every year and 31% is the cause of all global deaths. The purpose of this study was to determine the level of public knowledge about heart health in the covid-19 pandemic era.  Method: The sampling technique used consecutive sampling, namely subjects who came and met the inclusion criteria were included in the study until the number of samples was met. This study is expected to provide information to the public about heart health and its relationship to the era of the covid-19 pandemic in the community/employees in the USU Medical Faculty Results: In this study, the number of samples was 100 people, the age group > 30 years (62%), while the age group ≤ 30 years (38%). The majority of the sample works as official governments 40 people (40%), had good score predicate, good level of knowledge is Government Employees 20 peoples (20%), health workers (20%), while the level of education is Strata 1.  Conclusion: The level of knowledge of the community about heart health in the Covid-19 pandemic era is good with education level Strata 1 and most of them are Government Employees
Co-Authors Aldino Satria Adhitya Ali Nafiah Nasution Andika Sitepu Andre Pasha Ketaren andrico tobing Anggia C Lubis Anggia Chairuddin Lubis Bertha Gabriela Napitupulu Bertha Gabriella Napitupulu Cut Aryla Andra Dedi Ansyari Edison Bun Herman William Parlindungan Nizam Z Akbar Nizam Zikri Akbar Raynaldo, Abdul Halim Refli Hasan Tapisari Tambunan Zainal Safri Zainal Zafri Zulfikri Mukhtar