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All Journal Medical Journal of Indonesia The New Ropanasuri Journal of Surgery
Hanifah Oswari
Division of Gastrohepatology, Department of Child Health, 2 Faculty of Medicine University of Indonesia,Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Cholestasis sepsis at neonatology ward and neonatal Intensive Care Unit Cipto Mangunkusumo Hospital 2007 : incidence, mortality rate and associated risk factors Bachtiar, Kadim S.; Oswari, Hanifah; Batubara, Jose R.L.; Amir, Idham; Latief, Abdul; Firman, Kemas
Medical Journal of Indonesia Vol 17, No 2 (2008): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.517 KB) | DOI: 10.13181/mji.v17i2.306

Abstract

Cholestatic jaundice represents serious pathological condition. Septic-cholestasis is a kind of hepato-cellular cholestasis that occured during or after sepsis caused by biliary flow obstruction. This is a cohort study from February to June 2007 on neonatal sepsis patients at Neonatology ward Department of Child Health Faculty of Medicine University of Indonesia-Cipto Mangunkusumo General National Hospital. Aim of this study is to find out the incidence of intrahepatic cholestasis in neonatal sepsis, associated risk factors, and mortality rate in neonatal cholestasis-sepsis. From 138 neonatal sepsis patients, the incidence of intrahepatic cholestasis is 65.9%. None of the risk factors tested in this study showed statistically significant result. Mortality rate of neonatal cholestasis-sepsis is 52.8%. (Med J Indones 2008; 17: 107-13)Keywords: cholestasis intrahepatic, neonatal sepsis, cholestasis sepsis, conjugated hyperbilirubinemia
Factors Affecting the Success Rate of Kasai Portoenterostomy Sastiono, Sastiono; Maheranny, Marethania; Oswari, Hanifah
The New Ropanasuri Journal of Surgery
Publisher : UI Scholars Hub

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Abstract

Introduction. Surgical repositioning of biliary drainage to the intestine (jejunum) through an artificial fistula (portoenterostomy) following surgical removal of extrahepatic residual biliary duct in biliary atresia, which is first proposed by Kasai has never been evaluated in our center. Thus, we run a study aimed to find out the successrate. Method. We run a cohort study retrospectively enrolled subjects with biliary atresia consecutively. A review of histopathology was carried out, and focused on degree of fibrosis as well as cirrhosis. Obtained data were subjected to statistical analysis using Fischer test and logistic regression. Results. Out of 15 subjects enrolled in the study, we found successmanagement in five subjects based on three months of icteric free period. Using Fischer test, we found a significant correlation (p = 0.04) between degree of fibrosis and outcomes in 1-year period with relative risk of 4 (CI 95% 1.5–10.65). Conclusion. Affecting factors in successrate of portoenterostomy remains unclear; degree of fibrosis might be the one. Different center reports different outcome as the histopathology characteristics varies in different center.
Co-Authors Abdul Latief Idham Amir Jose RL Batubara Kadim S. Bachtiar Kemas Firman Maheranny, Marethania Sastiono, Sastiono