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All Journal Jurnal Kesehatan Reproduksi JURNAL KESEHATAN PERINTIS JATI EMAS (Jurnal Aplikasi Teknik dan Pengabdian Masyarakat) Jurnal Kebidanan dan Keperawatan Aisyiyah Indonesian Journal of Midwifery (IJM)
Luh Ari Arini
Universitas Pendidikan Ganesha
Humanities Education Engineering Health Professions Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Kesehatan Reproduksi

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Studi Literatur Perbedaan Ekspresi Messenger Ribonucleid Acid (mRNA) Reseptor Androgen Setelah Pemberian Testosteron antara Penis dan Kelenjar Prostat Tikus Wistar Jantan (Rattus Norvegicus) Pascakastrasi Luh Ari Arini
JURNAL KESEHATAN REPRODUKSI Vol 6, No 1 (2019)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (397.56 KB) | DOI: 10.22146/jkr.37823

Abstract

Background: Aging process (andropause) in men will cause a decrease in testosterone hormones, in other that decrese of androgen receptor (testosteron and dhyhidrtestosterone) in target organ, can be seen from AR mRNA expression. Andropause finaly impact of male reproductive organ, so given testosterone hormone therapy is important to restore the condition. Giving testosterone hormone causes increase the expression of AR mRNA in the prostate gland and penis, but in these two organs there is a different increase.Objective: to know the difference of expression AR mRNA after administration of testosterone between prostate gland and penis.Method: This article used literature review from database of intisari sains medis.Results and Discussion: AR mRNA expression in the prostate gland is smaller than the penile tissue, due to the prostate gland in addition to the 5α reductase enzyme there are also many aromatase enzymes. In the normal prostate gland the amount of 5α reductase is small, so the addition of testosterone is converted to DHT but also in aromatization to estrogen. Therefore, fewer androgen receptors are found compared to the tissue of the penis, in addition expression of AR mRNA in the preputial penis is higher than the prostate gland.Conclusion: Penile tissue is more responsive to testosterone and improves the function and maintenance of tissue especially in old. Keywords: androgen receptor mRNA; testosterone; penis and prostate
Co-Authors I Ketut Wijana Luh Gede Kusuma Dewi Putu Riesty Masdiantini