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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Journal of General-Procedural Dermatology & Venereology Indonesia
Saut Sahat Pohan
Faculty of Medicine Airlangga University/ Dr. Soetomo Hospital, Surabaya
Immunology & microbiology Medicine & Pharmacology Public Health

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Perbedaan antara Uji Transformasi Limfosit dengan Uji Tempel Obat pada Pasien Erupsi Obat Karina, Dhita; Rahmadewi, Rahmadewi; Pohan, Saut Sahat
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (327.981 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-6

Abstract

SurabayaABSTRAKLatar belakang:Diagnosis erupsi obatseringditegakkan berdasarkan anamnesis dan pemeriksaanklinis sajasehingga sulit untuk mengetahui obat penyebabnya. Pemeriksaan penunjang diperlukan untukdiagnosis yang lebih pastidan mengetahui penyebabnya. Uji Tempel Obat (UTO) adalah prosedur in vivoyang sering digunakan di praktek sehari-hari dan sensitivitasnya sebesar 30-50%. Uji Transformasi Limfosit (UTL) adalah suatu pemeriksaan laboratorium dengan prosedur invitroyangsensitivitasnya dilaporkan 70-90% dalam mendiagnosis erupsi obat. Tujuan:Menganalisis perbedaan antara hasil UTO dan UTL pada pasienerupsi obat.Metode:Penelitian cross sectionaldilakukan terhadapduapuluh dua pasien dengan riwayat erupsi obat di Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. DilakukanUTO pada punggung pasiendanpengambilandarah venapasien untuk pemeriksaan UTL. Hasil:Dari duapuluh duapasiendidapatkan hasil positif UTO pada tujuhpasiendan negatifpada lima belaspasien, sedangkan hasil positif UTL pada dua puluh pasien dan negatif pada duapasien.Simpulan:Terdapatperbedaan yang signifikan antara UTO dan UTLpada pasien erupsi obat. Kesesuaian dua pemeriksaan ini sebesar 40,9%,yang berarti UTL dapat dilakukan bila hasil UTO negatif atau meragukan.
Cumulative exposure to solar ultraviolet A & B increases apoptosis of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-Lymphocytes in outdoor workers Hidayati, Afif Nurul; Pohan, Saut Sahat; Pudjirahardjo, Widodo J.; Effendy, Isaac
Journal of General - Procedural Dermatology & Venereology Indonesia
Publisher : UI Scholars Hub

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Abstract

Background: Exposure to ultraviolet A & B (UVA-UVB) plays a role in the survival of human life, but it may cause negative effects, such as immunosuppression and skin cancer. The effect of solar UVA-UVB exposure on apoptosis (Bax/Bcl-2 ratio) of peripheral blood cutaneous lymphocyte antigen (CLA)+ T-lymphocyte; the immune competent cells in the skin, has not been investigated. Apoptosis of peripheral blood CLA+ Tlymphocyte affects its function; which serves as the skin's resistance and is involved in infectious diseases, skin inflammation, and malignancies. This study observed the effect of solar UVA-UVB to apoptosis (Bax/Bcl2 ratio) of peripheral blood CLA+ T-lymphocytes. Methods: An observational cohort study of 37 male outdoor workers (caddies on the golf course) and 33 indoor workers in Surabaya, aged 20-45 years, with skin phototype IV/V. Measurement of solar UVA-UVB doses received by the subjects was conducted for 2, 4, and 8 weeks. Examination of Bax and Bcl-2 of peripheral blood CLA+ T-lymphocyte was conducted at the beginning of the study, after 4 and 8 weeks. Results: The average dose of solar UVA-UVB for 8 weeks received by outdoor workers was 12450.51±3948.81 (J/m2 ) and that by indoor workers was 1793.97±1518.46 (J/m2 ). Exposure to solar UVAUVB leads to the increase of apoptosis (Bax/Bcl-2 ratio) of peripheral blood CLA+ T-lymphocytes (p=0.003). Conclusion: Cumulative exposure to solar UVA-UVB radiation in high-dose or received within 8 weeks resulted in the increase in apoptosis of peripheral blood CLA+ T-lymphocytes.
Co-Authors Afif Nurul Hidayati, Afif Nurul Dhita Karina, Dhita Effendy, Isaac Rahmadewi Rahmadewi Widodo J. Pudjirahardjo