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All Journal JURNAL ILMU KEFARMASIAN INDONESIA Pharmacoscript Kartika : Jurnal Ilmiah Farmasi
Titta Hartyana Sutarna
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Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

 1 
Pembuatan dan Karakterisasi Ko-kristal Flukonazol-Resorsinol Fikri Alatas Alatas; Hestiary Ratih; Titta Hartyana Sutarna; Yoga Windu Wardhana; Dini Tereslina; Sundani Nurono Soewandhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.779

Abstract

Fluconazole (FLU), an oral antifungal widely used in the treatment of vaginitis andcandidiasis, is known to have low bioavailability due to its low solubility. The purpose of this studywas to prepare and characterize co-crystal fl uconazole-resoscinol (FLU-RES). The preparation ofco-crystal was performed by grinding together the equimolar mixture of FLU-RES which is drippedwith a few ethanol. Powder X-ray diff raction, diff erential scanning calorimetry (DSC), and polarizedmicroscopy methods were performed to characterize the formation of FLU-RES co-crystal. Relevantphysicochemical properties include solubility tests in water and dissolution tests in pH 1.2; 4.5 and6.8 buff er solution. The powder X-ray diff ractogram of FLU-RES milled result showed the presenceof new peaks and loss of the main peaks of FLU and RES. The characterization of grinding result byDSC and polarized microscopy methods also showed the co-crystal formation between FLU and RES.The solubility of FLU-RES co-crystal in water is solubility two folds more than pure FLU, while itsdissolution rate is 1.67-1.72 times faster than pure FLU.
Co-Authors Alya Nur Asilla Dini Tereslina Fikri Alatas Hestiary Ratih Nur Achsan Al-Hakim Sintia Resni Pratiwi Sundani Nurono Soewandhi Yoga Windu Wardhana