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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medical Journal of Indonesia YARSI Medical Journal
Praseno Praseno
Department of Microbiology, Faculty of Medicine, Gadjah Mada University, Yogyakarta
Immunology & microbiology Medicine & Pharmacology Neuroscience

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Comparative efficacy of Phyllanthus niruri L. and cotrimoxazole in the treatment of skin infection caused by Staphylococcus aureus. Praseno, Praseno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 33, No 02 (2001)
Publisher : Universitas Gadjah Mada

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Abstract

Background: Traditional medicine has been widely used in our community and many of them were found to be effective in the treatment of various diseases. Previous studies showed that Phyllanthus niruri L. has an effect as immunostimulator and antiviral activities.Objective: The aim of this study was to evaluate the efficacy of Phyllanthus niruri L. in the treatment of skin infection caused by Staphylococcus aureus.Materials and Methods: Thirty mice of Swiss strain were infected with 2x100 colony forming unit of S.aureus subcutaneously. The mice were then devided into 3 groups; Phyllanthus niruri L.-treated group, cotrimoxazole-treated group, and control group. Treatmen
Antiviral activity of Momordica charantia: a preliminary study on in vitro anti herpes simplex virus Praseno, Praseno
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 03 (1997)
Publisher : Universitas Gadjah Mada

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Traditional medication has been used by Indonesian people since long time ago and still continuing up to the present time. Many of them proved to be effective in curing various diseases. In this study an in vitro activity of Momordica charantia againts Herpes Simplex Virus type 2 has been evaluated by standard method of plaque reduction assay. The aim of this study is to determine whether traditional medicine we are searching has an antiviral activity. The results showed that total inhibition of plaque formation on HSV 2-infected Vero cell line was achieved at concentration of 8% v/v of crude extract, whereas the concentration of 1% v/v was capable of reducing the number of plaques by approximately 50% (inhibitory dose50= ID50). These results were very interesting as even with only small amount of crude extract we could get ID50. We expect that much lower concentration will be required to obtain ID50 if we use purified extract in the assay. Further studies are needed to elucidate other properties of the extract, including its in vivo antiviral activity, possible effect on other viruses, and mechanism of action.Key words: antiviral activity - herpes simplex virus - Momordica charantia - traditional medicine - plaque reduction assay
Anti herpes simplex virus property of Phyllanthus urinaria (L) as shown by plaque reduction assay Praseno, Praseno
Medical Journal of Indonesia Vol 7, No 1 (1998): January-March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (334.056 KB) | DOI: 10.13181/mji.v7i1.794

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[no abstract available]
Increased susceptibility of S. aureus to ampicillin during exposure to rifampicin: A distinct mechanism of antimicrobial synergism Praseno, Praseno
Medical Journal of Indonesia Vol 6, No 2 (1997): April-June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (400.834 KB) | DOI: 10.13181/mji.v6i2.809

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Isolation and presumptive serological characterization of hantavirus from wild rat (Bandicota indica) Praseno, Praseno; Suwarso, Suwarso
Medical Journal of Indonesia Vol 7, No 3 (1998): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.972 KB) | DOI: 10.13181/mji.v7i3.763

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[no abstract available]
OTOVAKSIN SEBAGAI TERAPI ALTERNATIF INFEKSI MYCOBACTERIUM TUBERCULOSIS PADA TIKUS PUTIH (RATTUS NORVEGICUS) Praseno, Praseno; Nurrokhman, Nurrokhman; Fiatiningsih, Istiana
Jurnal Kedokteran YARSI Vol 15, No 3 (2007): SEPTEMBER-DESEMBER 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jky.v15i3.1077

Abstract

Tuberculosis (TB) is still an important public health problem, especially in developing countries such as Indonesia. Efforts have been made to overcome the problem, however, number of cases is still high. This is due to various factors which might affect the development of the disease. Increasing number of resistant strains against antimycobacterial drugs is one of the major factors. Therefore, alternative method to control TB is needed.The aim of this study was to evaluate the effectiveness of autogenous vaccine on healing process of infection caused by Mycobacterium tuberculosis in rats. Eighteen Wistar rats (Rattus norvegicus) were infected with 109 colony forming unit of M. tuberculosis subcutaneously. One week after infection, the rats were divided randomly into 2 groups, first group were treated with autogenous vaccine and the other were left untreated (control group). Autogenous vaccine was given subcutaneously with the dose of 108 cfu/0,1 ml every 7 days 3 times. Subcutaneous nodules were evaluated every 3 days and weight gain was evaluated 3 times. Laboratory examinations were done, including acid fast bacilli stain, histopatological feature and serologic test. The result showed that recovery of subcutaneous nodules in autovaccine treated group of rats was faster than that of untreated control group. Acid fast bacilli staining showed that the number of micobacteria found in the lung, liver, spleen and kidney of autovaccine treated group were much lower than those found in the control group. Histopathology features showed that lymphocytes infiltration in the lung and other organs was heavier in the control group than that of treated group. In conclusion, animal study on rats showed that autogenous vaccine had effective therapeutic effect on healing process for M. tuberculosis infection.   
Co-Authors Fiatiningsih, Istiana Nurrokhman, Nurrokhman Suwarso Suwarso