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Sri Sofyani
Department of Child Health, University of North Sumatera Medical School/H. Adam Malik Hospital
Health Professions Medicine & Pharmacology

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Recurrent abdominal pain in adolescents with anxiety and depression disorders Fastralina Fastralina; Sri Sofyani; M. Joesoef Simbolon; Iskandar Z. Lubis
Paediatrica Indonesiana Vol 53 No 1 (2013): January 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (101.65 KB) | DOI: 10.14238/pi53.1.2013.16-20

Abstract

Background Anxiety and depression disorders in adolescentsmay affect their academic performances and social functioningat school. Adolescents with these disorders sometimes developrecurrent abdominal pain (RAP).Objective To assess the occurence of recurrent abdominal painamong adolescents with anxiety and depression disordersMethods We conducted a cross-sectional study from Augustto September 2009 in 12-18 year-old adolescents from 3 juniorhigh schools and 3 senior high schools in Secanggang Subdistrict,Langkat District, North Sumatera Province. We screened 960adolescents. Subjects were selected by consecutive samplingand instructed to fill the child behavior checklist (CBCL) andchildren's depression inventory (CDI) forms. Those with suspectedanxiety/depression (CBCL score 2: 12 for boys and 2: 14 for girls)and those with suspected depression (CDI score 2: 13) were thenexamined by a psychiatrist. Adolescents diagnosed with anxiety ordepression disorders were instructed to fill the RAP questionnairebased on Apley and Naish criteria.Results From the CBCL and CDI forms, 250 students weresuspected of having anxiety and/or depression. From these,144 students participated in this study. Of the 84 students withanxiety disorders, 60 (71.4%) students suffered from RAP. Ofthe 60 students with depression disorders, 31 (51 %) sufferedfrom RAP.Conclusion Adolescents with anxiety or depression are morelikely to have recurrent abdominal pain.
Effect of lansoprazole on quality of life in adolescents with recurrent abdominal pain Sri Yanti Harahap; Selvi Nafianti; Sri Sofyani; Supriatmo Supriatmo; Atan Baas Sinuhaji
Paediatrica Indonesiana Vol 53 No 2 (2013): March 2013
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.566 KB) | DOI: 10.14238/pi53.2.2013.99-103

Abstract

Background Recurrent abdominal pain (RAP) is one of the mostcommon complaints in adolescents. Treatment for RAP dependson the etiology. Lansoprazole has been shown to be effective ongastroesophageal reflux disease (GERD), but further study isneeded to assess the effects of lansoprazole on RAP.Objective To assess quality of life (QoL) of RAP patients whoreceived lansoprazole compared to placebo treatment.Methods This randomized, clinical trial was conducted in theSecanggang District, Lan gkat Regency, North Sumatera, fromAugust to October 2009. Patients who met the Apley criteria forRAP diagnosis were enrolled in the study. Subj ects were dividedinto two groups: those who received 30 mg lansoprazole daily andthose who received placebo, for 14 days. Quality oflife was assessedusing the Pediatrics Quality of Life (PedsQL) version 4.0 beforeadministration oflansoprazole/placebo and reassessed 30 days aftertreatment. Efficacy of treatment was assessed by comparing theQoL before and after treatment in the two groups.Results A total of 98 adolescents, aged 12 - 18 years, wereenrolled in the study and divided into two groups: lansoprazoleand placebo. There was no significant difference QoL in physicalhealth (mean differences 95%CI -109.19 to 1.02; P=0.054),emotional health (mean differences 95%CI -29.26 to 45.48;P=0.666), social functioning (mean differences 95%CI -42.91to 31.69; P=0.766), and sch ool functioning (mean differences95%CI -56.97 to 24.32; P= 0.430), before and after treatmentin the two groups.Conclusion There is no significant difference in QoL between thetwo groups of adolescents with RAP before and after lansoprazoletreatment.
Risk factors of childhood leukemia Paulina K. Bangun; Bidasari Lubis; Sri Sofyani; Nelly Rosdiana; Olga R. Siregar
Paediatrica Indonesiana Vol 54 No 6 (2014): November 2014
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi54.6.2014.358-64

Abstract

Background The incidence of childhood leukemia has increasedannually. Recent studies have shown that childhood leukemia isinitiated in utero, and have focused on prenatal risk factors suchas birth weight and parental age. Exposure to pesticides andradiation, as well as parental smoking, breastfeeding, and thenumber of older siblings have also been sugges ted as risk factorsfor childhood leukemia.Objective To evaluate possible risk factors for childhood leukemia,including birth weight, parental age, and other risk factors.Methods This case-con trol study was conducted from October2011 to February 2012 in Haji Adam Malik Hospital, Medan .Case subjects were children aged below 18 years and diagnosedwith leukemia. Control subjects were children aged below 18years who were diagnosed with any non-cancerous acute illnessesin this hospital, and individually matched for age and gen der tothe case subject group. Patients and parents were asked to fill astructured questionnaire. Data was analyzed using conditionallogistic regression .Results A total of 140 subjects were eligible, with 70 subjects ineach group. Birth weight 2: 4000 g and maternal age 2:35 yearswere significant risk factors with OR 10.13 (95%CI 1.124 to 91.2 7)and OR 4.98 (95%CI 1.276 to 19.445), respectively. Paternal ageof 2:35 years was not a significant risk factor. Exposure to pesticideswas also noted as another significant risk factor (OR= 6.66; 95%CI2.021 to 21.966) .Conclusion High birth weight, advan ced maternal age, andexposure to pesticides are risk factors of childhood leukemia.
Co-Authors Atan Baas Sinuhaji Bidasari Lubis Fastralina Fastralina Iskandar Z. Lubis M. Joesoef Simbolon Nelly Rosdiana Olga R. Siregar Paulina K. Bangun Selvi Nafianti Sri Yanti Harahap Supriatmo Supriatmo