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Wayan Retayasa
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Health Professions Medicine & Pharmacology

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Efficacy of dexamethasone for lung maturity in preterm delivery in association with lamellar bodies count Ni Made Sumiartini; Hendra Santoso; Wayan Retayasa; Made Kardana
Paediatrica Indonesiana Vol 47 No 3 (2007): May 2007
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.286 KB) | DOI: 10.14238/pi47.3.2007.115-9

Abstract

Background Organ immaturities in preterm infants may result inperinatal death. One of the diseases is respiratory distress syndrome(RDS) which is caused by lung immaturity. Dexamethasone is oftenused to accelerate maturity of infant lungs.Objective To determine the efficacy of dexamethasone on lungmaturity measured by lamellar bodies count.Methods A quasi experimental study was done at PerinatologyDivision, Department of Child Health, Medical School, UdayanaUniversity, Sanglah Hospital, Denpasar. We recruited 72 subjects;36 subjects were given four times intramuscular dexamethasone5 mg every twelve hours before delivery. Thirty six subjects whodid not receive dexamethasone belonged to control group. Infants’lungs maturity assessment was performed using lamellar bodiescount taken from amniontic fluid.Results The gestational age ranged between 28 to 36 weeks, withthe mean gestational age in dexamethasone group was 32.2 (SD1.76) weeks and that in control group was 31.7 (SD 2.65) weeks.The efficacy of dexamethasone therapy on lung maturity wassignificant with Fisher’s exact test P<0.0001, 95%CI 2.546;11.173. Using multivariate logistic regression analysis, there wassignificant correlation between dexamethasone and lung maturitymeasured by lamellar bodies count [OR=239.39; P<0.0001,95%CI 22.12;526.53].Conclusion Administration of dexamethasone in pregnantwomen during preterm delivery significantly improves lungmaturity measured by lamellar bodies count.
Early neonatal mortality rate and the risk factors in Wangaya hospital Made lndah Nastiti Utami Budha; Wayan Retayasa; Made Kardana
Paediatrica Indonesiana Vol 48 No 5 (2008): September 2008
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (123.2 KB) | DOI: 10.14238/pi48.5.2008.306-11

Abstract

Background The first week of life of a neonate is a critical period.In Asia, early neonatal mortality rate remains high.Objective To investigate early neonatal mortality rate and the riskfactors in Wangaya Hospital.Methods A cross sectional study was carried out retrospectivelyon neonates registered at Perinatology Unit, Wangaya HospitalDenpasar, Bali since January 2006. The study was done fromOctober to November 2007. Data was obtained from medicalrecord, analyzed as univariate using chi-square test or Fisher'sexact test and multivariate logistic regression analysis model.Results Early neonatal mortality rate in Wangaya Hospital was 38.7per 1000 livebirths. Univariate analyses showed that there werefive significant risk factors of early neonatal death, i.e., respiratorydistress, asphyxia, birth weight less than 2500 grams, sepsis, andgestational age less than 3 7 weeks. Multivariate analysis showedthat those five variables were significant as risk factors of earlyneonatal death i.e., OR (95% confidence interval) for respiratorydistress: 16.8 (3.7 to 76.6)], asphyxia: 13.5 (6.1 to 29.9)], birthweight <2500 grams: 8.1 (3.3 to 19.9)], sepsis: 7.3 (3.1 to 17.1),and gestational age <37 weeks: 3.5 (1.6 to 7.8)].Conclusions Early neonatal mortality rate in Wangaya Hospitalremains high. Respiratory distress, asphyxia, birth weight <2500gram, sepsis, and gestational age <37 weeks were independent riskfactors of early neonatal death.
Clinical gestational age assessment in newborns using the new Ballard score Erman Erman; Wayan Retayasa; Soetjiningsih Soetjiningsih
Paediatrica Indonesiana Vol 46 No 3 (2006): May 2006
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi46.3.2006.97-101

Abstract

Background The new Ballard score (NBS) is presently consid-ered to be the most reliable method for estimating clinical gesta-tional age (GA) in newborn infants.Objective The aim of this study was to compare the NBS andDubowitz/Finnstrom score against ultrasonography assessment ofgestational age.Methods A cross sectional randomized study involving neonatesborn in Sanglah Hospital, Bali, June to August 2004 was carriedout. Gestational age was estimated within the first 24 hour by ei-ther Dubowitz/Finnstrom score or NBS confirmed by USG (C-GLMP) as the gold standard.Results One hundred and fifty-five newborns were enrolled in thisstudy. Subjects were randomly divided into two groups, theDubowitz/Finnstrom score group (76 newborns) and NBS group(79 newborns). The mean age of mothers was 28.4 years old; meanbirth weight was 3151.3 g (SD 596.3 g). The proportion of small forGA, appropriate for GA, and large for GA were 6%, 77% and 17%,respectively. Pearson correlation ( r ) between C-GLMP andDubowitz/Finnstrom score was 0.71 (P<0.005); and with NBS was0.79 (P<0.005) .Conclusion The strength of correlation between either NBS orDubowitz/Finnstrom score and USG assessment of gestational ageare similar
Henoch - Schonlein Purpura Wayan Retayasa; Hendra Santosa
Paediatrica Indonesiana Vol 37 No 3-4 (1997): March - April 1997
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.675 KB) | DOI: 10.14238/pi37.3-4.1997.86-90

Abstract

Henoch-Schonlein purpura (HSP) is an immunologically mediated syste­mic vasculitis of small blood vessels that primarily, involves skin 100%, gastrointestinal tract 50-70%, joint 70% and the kidney 20-100%. The most common clinical manifes­tation are intermittent purpura, athralgia, abdominal pain and hematuria. The diagno­sis of HSP based on clinical manifestation, laboratory finding and skin biopsy. The manifestation of HSP in a case of eleven year old Balinese girl were maculo papular rash of the flexor, and extensor region of the legs, butocks and fore arms, abdomininal pain and bloody stools Laboratory finding were WBC 20,000/pl, platelet count 490,000/pi, Bleeding time 3 minutes, clothing time 14 minutes PIT 23,7 second, Pro­thrombin time 11,2 second. The blood urea nitrogen, 16 mg/dl, creatinine, 0,66 mg/dl. Complemen C4, 39 mg/dl, IgA 355 mg/dl ASTO and CRP were negative. Histo­logic examinitation showed epidermis with hiperkeratosis, proliferation of subepidermic conective tissue, with magnitude of leucosites infiltration surounding small blood vesels with the conclution was according to feature of HSP.
Co-Authors Erman Erman Hendra Santoso I Made Kardana Luh Putu Ratna Sundari Made lndah Nastiti Utami Budha Ni Made Sumiartini Soetjiningsih Soetjiningsih