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Sumadiono Sumadiono
Department of Child Health, Gadjah Mada University Medical School/Dr. Sardjito Hospital, Yogyakarta
Health Professions Medicine & Pharmacology

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Influence of zinc on severity of common cold in children Cahalafa Shinta Caesar; Mohammad Juffrie; Sumadiono Sumadiono
Paediatrica Indonesiana Vol 52 No 6 (2012): November 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (103.721 KB) | DOI: 10.14238/pi52.6.2012.324-8

Abstract

Background Symptomatic treatment of common cold in childrendoes not reduce the duration and severity of disease. Since zinc hasbeen used to enhance cellular and humoral immunity, it has thepotential to reduce the severity of the common cold. However, theeffects of zinc on the common cold have been inconclusive. Theuse of zinc to treat cold symptoms deserves further studies.Objective To determine the effect of zinc supplementation onthe severity of the common cold in children.Methods We performed a randomized, double􀁁blind, controlledtrial in children aged 3􀁁 5 years who were diagnosed Mth a commoncold at primary health care centers in Gedongtengen, Umbulharj 0I and Kotagede II, Yogyakarta. Subjects were collected byconsecutive sampling and their parents were interviewed. Severityof illness was categorized as mild, moderate or severe.Results One hundred fourteen patients with common cold weredivided into 2 groups of 57 subjects each. One group receivedzinc supplementation while the other group received a placebo.Subjects with fever received additional paracetamol. After 7 daysof treatment, there were no significant differences in clinicalimprovement in the zinc group (80.7%) compared to that of theplacebo group (78.9%), P􀁂O.83.Conclusion The severity of the common cold in children aged3􀁁5 years was not significantly different in those who receivedzinc supplementation compared to placebo. [Paediatr Indones.2012;52:324-8].
Effects of Phyllanthus niruri on the severity of the common cold in children Ari Dwi Ratna Kusumaningrum; Sumadiono Sumadiono; Yati Soenarto
Paediatrica Indonesiana Vol 52 No 6 (2012): November 2012
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.118 KB) | DOI: 10.14238/pi52.6.2012.346-51

Abstract

Background Common cold is a selfô€€µlimited disease, howeverit poses a significant burden on productivity and communityhealth. Unfortunately, there has been no standard medicationfor childhood common cold, whereas some herbs \\lith immuneô€€µmodulating properties, such as Phyllanthus niruri extract (PNE),might be beneficial but has not been thoroughly studied.Objective To evaluate the effect of PNE administration on theseverity of common cold symptoms in children.Methods We performed a randomized, doubleô€€µblind, controlledtrial in children aged 2ô€€µ6 years who were diagnosed Mth a commoncold at primary health care centers in Sewon and Jetis in Bantul,as well as in Gondomanan and Gedongtengen in Yogyakarta.Subjects were collected by consecutive sampling and parentswere interviewed. We assessed illness severity by Hemila scoringfor the common cold.Results A total of 100 subjects were included Mth 50 subjects ineach intervention group. After treatment, there was no significantdifference in common cold severity between the PNE and thecontrol groups for all symptom score components, including cough(0.87 vs 0.71, Pô€€½0.36), nasal symptom (0.90 vs 1.10, Pô€€½0.54),coryza ( 0.44 vs 1.10, P=0.54), and systemic symptom (0.10 vs0.10, Pô€€½0.94).Conclusion Administration of PNE for 6 days did not provide asignificant benefit in reducing the severity of the common coldcompared to placebo in children aged 2 - 6 years. [PaediatrIndanes.2012;52:346-51].
Co-Authors Ari Dwi Ratna Kusumaningrum Cahalafa Shinta Caesar Mohammad Juffrie Yati Soenarto