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All Journal Jurnal Farmamedika (Pharmamedica Journal)
Devi Ratnasari
Sekolah Tinggi Teknologi Industri dan Farmasi Bogor
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

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SINTESIS NANOPARTIKEL PERAK MENGGUNAKAN EKSTRAK KULIT BAWANG MERAH (Allium cepa L.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP BAKTERI Staphylococcus aureus Triyani Sumaiti; Devi Ratnasari; Dinda Dwi Mutiani
Jurnal Farmamedika (Pharmamedika Journal) Vol 3 No 1 (2018): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.081 KB) | DOI: 10.47219/ath.v3i1.25

Abstract

Synthesis of silver nanoparticle and determination of its antibacteial activity for Staphylococcus aureus were studied in this research. Silver nanoparticle (NPAg) were synthesized using method green synthesisby reacting extract peel of onion (Allium cepaL.) and silver nitrate (AgNO3). NPAg synthesis used variation AgNO3 0,1mM (F1); 0,5mM (F2) and 1,0mM (F3). Characterization using UV-Visible spektroscopy and Particle Size Analyzer (PSA). UV-Visible spektroscopy analysis showed that the NPAg at F2 and F3 in 400-500 nm wavelenght. The particle size used PSA at F1, F2 and F3 in 390,7 nm, 62,34 nm and 50,63 nm. F3 has been tested for antibacteial activity S.aureus, the result showed that the antibacterial activity at F3 much better than AgNO3 1,0 mM which is not nanometer scale.
UJI AKTIVITAS SALEP EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava Linn.) TERHADAP LUKA BAKAR DERAJAT II PADA TIKUS JANTAN PUTIH Triyani Sumiati; Devi Ratnasari; Liana Febriyani
Jurnal Farmamedika (Pharmamedika Journal) Vol 2 No 1 (2017): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (602.88 KB) | DOI: 10.47219/ath.v2i1.32

Abstract

Psidium guajava Linn. known as guava leaves is a medicinal plant that has been used to treat diseases, including burns medicine. From the results of the study note that the extract of guava leaves ethanol can heal burns. To facilitate its use, then made ointment preparations of guava ethanol extracts. The purpose of this research is to make an ointment formula ethanol extract of guava leaves which has a healing effectiveness on a second degree burns. Extraction of guava leaf made by the process of maceration, then the liquid extract was concentrated by rotary evaporator to obtain a concentrated extract of guava leaf. An ointment formulations ethanol extract of guava leaf are made with concentrations respectively 30%, 35%, and 40. The effectiveness test of the healing of burns grade II using 5 groups: negative control (ointment base), positive control (Bioplacenton®), ointments ethanol extract of guava leaves 30%, 35%, and 40%. The study was conducted . of male white rats with severe between 200 – 400 grams. Observations up to 21st day. These result by using Tukey Test indicate that the concentration of guava leaf extract 35% , The results of this study indicate that the variation concentration of guava leaf extract gives a healing effect that does not differ significantly to healing second degree burns in male white rats.
KARAKTERISASI NANOVESIKEL TRANSFERSOM SEBAGAI PEMBAWA “RUTIN” DALAM PENGEMBANGAN SEDIAAN TRANSDERMAL Devi Ratnasari; Effionora Anwar
Jurnal Farmamedika (Pharmamedika Journal) Vol 1 No 1 (2016): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (832.094 KB) | DOI: 10.47219/ath.v1i1.40

Abstract

Transdermal become the alternative to deliver low solubility compound and low bioavalibility when given orally. Rutin is a flavonoid compound are found in watermelon and citrus. Rutin shows a low absorption when administered orally so the alternative is given in the transdermal route. A variety of approaches taken to increase the penetration of transdermal, one with nanovesikel carrier system. Transfersome is nanovesicle 200-300 nm sized composed of phospholipids, surfactants and water to increase penetration in trasndermal route. This study was to characterization transfersome containing rutin. The result show the size of transfersome < 150 nm, polydispersity index about 0.1 to 0.3, zeta potential less than -30 mV and entrapment efficiency > 80%.
SINTESIS DAN KARAKTERISASI CANGKANG KAPSUL KERAS DARI GELATIN TULANG IKAN LELE DUMBO (CLARIAS GARIEPINUS Triyani Sumiati; Devi Ratnasari; Ari Setiadji; Siti Rosidah Hanapiah
Jurnal Farmamedika (Pharmamedika Journal) Vol 5 No 2 (2020): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v5i2.106

Abstract

Kapsul adalah bentuk sediaan obat terbungkus cangkang kapsul keras atau lunak. Cangkang kapsul dibuat dari gelatin dengan atau tanpa zat tambahan lain. Gelatin merupakan suatu zat yang diperoleh dari hidrolisa parsial dari kulit atau tulang hewan. Sumber gelatin yang dapat digunakan sebagai bahan dasar pembentuk kapsul cangkang keras diantaranya tulang atau kulit dari sapi, babi, ikan. Ikan lele dapat digunakan sebagai bahan dasar untuk pembuatan gelatin. Penelitian ini bertujuan untuk membuat dan mengevaluasi karakteristik kapsul cangkang keras dari gelatin yang dibuat dari gelatin tulang ikan lele dumbo (Clarias garepinus). Proses pembuatan gelatin dilakukan dengan menggunakan cara asam. Hasil pengujian gelatin menunjukan nilai pH gelatin 4,85, kadar air 13,5 %, viskositas 180-190 Cps, kadar abu 3,2% dan kekuatan gel 150 g/cm2. Gelatin yang dihasilkan kemudian digunakan untuk pembuatan cangkang kapsul keras yang dibedakan menjadi 2 formula dengan memvariasikan jumlah gelatin yang digunakan (Formula I = 25 g dan formula II = 35 g gelatin). Evaluasi terhadap karakteristik cangkang kapsul yang meliputi dimensi cangkang kapsul, pengukuran volume cangkang kapsul, waktu hancur dalam air dan larutan asam, kadar air dan kerapuhan. Hasil pengujian karakteristik yang tidak memenuhi persyaratan pada formula I adalah penetapan kadar air dan kerapuhan, sedangkan pada formula II hanya pada penetapan kadar air.
Co-Authors Ari Setiadji Dinda Dwi Mutiani Effionora Anwar Liana Febriyani Siti Rosidah Hanapiah Triyani Sumaiti Triyani Sumiati