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All Journal Paediatrica Indonesiana
I. G. G. Djelantik
Department of Child Health, Airlangga University Medical School/Dr. Soetomo Hospital, Surabaya, East Java
Health Professions Medicine & Pharmacology

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Thiamphenicol in the treatment of cholera in children Haroen Noerasid; Eko Sujanto; Ismoedijanto Ismoedijanto; Djoko Soejono; I. G. G. Djelantik; Surata Surata
Paediatrica Indonesiana Vol 21 No 9-10 (1981): September - October 1981
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi21.9-10.1981.197-204

Abstract

A study has been performed to measure the efficacy of thiamphenicol by comparing it with tetracycline as a standard drug. Eighty bacteriologically confirmed cholera patients were included in this study.Among them, 41 patients were treated with thiamphenicol while the other39 with tetracycline.Stool volume, duration of diarrhea and duration of hospitalization were higher in the thiamphenicol group. And the volume of intravenous and oral fluid therapy were less in the tetracycline group.Positive bacteriologic examinations of the second samples (taken on the second day of hospitalisation) of the thiamphenicol grollp were 41.46% as compared with 17.94% of the tetracycline group. But almost all o{ the third samples of both groups were negative.Clinical success rate of thiamphellicol was 95.12% and tetracycline was 100%. Thiamphenicol appeared to be effective against cholera in children.
Co-Authors Djoko Soejono Eko Sujanto Haroen Noerasid Ismoedijanto Surata Surata