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Dedi Subardja
Department of Child Health, Universitas Padjadjaran Medical School/Dr. Hasan Sadikin Hospital, Bandung, West Java
Health Professions Medicine & Pharmacology

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Clinical and Head Ultrasound Findings in Neonates after Administration of High Dose of Vitamin A R M Nurrachim; Ali Usman; Sjarif Hidajat; Dedi Subardja; Tina Agoestina; Jean Humphrey; George A. Taylor
Paediatrica Indonesiana Vol 34 No 7-8 (1994): July - August 1994
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1156.961 KB) | DOI: 10.14238/pi34.7-8.1994.197-208

Abstract

Vitamin A deficiency is a major cause of blindness and severe morbidity and mortality in young children. Supplementation of vitamin A in the community might reduce child mortality rates. The safety of high dose of vitamin A administered to neonates is not clear. We randomized 2058 neonates to receive either a single dose of 50 000 IU oral vitamin A (n=l031) or placebo (n=l027). Bulging fontanel and head circumference were assessed before and throughout 48 hours following dosing. Cranial ultrasound examination was carried out in 972 infants before and 24 hours after dosing to rule out intracranial hemorrhage and determine resistive index (Rl) of the anterior cerebral artery. Slight bulging fontanel occurred in 2. 7% and 4.4% of the infants at 24 hours. Moderate bulging fontanel was seen in 0.1% of study group, no severe bulging was observed. At 48 hours slight bulging fontanel was observed in 2.4% of control group and 4.5% in study group. No intracranial hemorrhage was found. Mean RI values were normal in both groups at baseline or 24 hours. Bulging fontanel was not associated with increased signs or symptom, or with increase in RI. Single oral dose of 50 000 vitamin A may cause a small increase in intracranial volume in a small proportion of infants, without increase in intracranial pressure.
Co-Authors Ali Usman George A. Taylor Jean Humphrey R M Nurrachim Sjarif Hidajat Tina Agoestina