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Upaya Peningkatan Pengetahuan tentang Efek Samping Obat pada Warga Dasa Wisma dalam Upaya Penerapan Farmakovigilans Inayatush Sholihah; Joko Santoso
PaKMas: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 2 (2021): November 2021
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.784 KB) | DOI: 10.54259/pakmas.v1i2.110

Abstract

The lack of public understanding and awareness about safe drug information and misleading social media news related to drug use is a new challenge that cannot be underestimated. The purpose of this community service was to overcome the problem of the lack of public knowledge about side effects, especially as an effort to implement pharmacovigilance in the community. The method started from intervention to the community included providing education (socialization) on the dangers of drug side effects and workshops on the use of the method of measuring drug side effects using the Naranjo algorithm. The target of this activity was the residents of the Mertoudan, Mojosongo, Surakarta would get additional knowledge about drug side effects and know how to monitor it, also creating people who are aware of drug side effects. This activity increased the knowledge of residents about drug side effects and the ability to measure the probability of the occurrence of drug side effects. The implementation of this activity received a good response from the Chairperson of Dasa Wisma and the participants, who were very enthusiastic to increase their knowledge about drug side effects and the measurement method with the Naranjo algorithm.
POTENSI DIURETIK FRAKSI EKSTRAK ETANOL DAUN SELEDRI (Apium graveilens Linn.) SECARA INVIVO SEBAGAI HERBAL ANTIHIPERTENSI joko santoso; Lanny Triana; Rr. Sri Wulandari; Ersta Zusvita; Dheny Rohmatika
Jurnal Kesehatan Kusuma Husada Vol. 11 No. 1, Januari 2020
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (191.118 KB) | DOI: 10.34035/jk.v11i1.833

Abstract

Hipertensi merupakan penyakit kenaikan tekanan darah lebih dari 140 mmHg. Hipertensi merupakan masalah utama kesehatan di dunia dan jumlah penderita semakin meningkat dari tahun ke tahun. Seiring dengan meningkatnya prevalensi hipertensi di Indonesia dan banyaknya faktor yang berpengaruh dalam pemilihan obat-obatan antihipertensi sintetik, maka dituntut terus untuk mengembangkan obat yang berasal dari alam. Seledri (Apium graveolens) telah diketahui mempunyai aktivitas antihipertensi dengan adanya kandungan apigenin yang berperan sebagai antagonis kalsium sehingga mempunyai efek vasodilatasi atau vasorelaksasi. Tujuan : Diketahuinya Tingkat dosis yang efektif dari ekstrak daun seledri sebagai obat hipertensi. Metode : Penelitian eksperimental post test only control group design. Hasil : Kelompok I (Dosis Ekstrak 300mg) memiliki Frekuensi BAK 4 kali, volume urin 1,80ml dan Potensi daya diuretic 20%, Kelompok II (Dosis Ekstrak 400mg) memiliki Frekuensi BAK 5 kali, volume urin 2,50ml dan Potensi daya diuretic 67%, Kelompok III (Dosis Ekstrak 500mg) memiliki Frekuensi BAK 6 kali, volume urin 2,85ml dan Potensi daya diuretic 90%, Kelompok IV (Furosemida) memiliki Frekuensi BAK 8 kali, volume urin 2,80ml dan Potensi daya diuretic 87%, Kelompok V (Aquades) memiliki Frekuensi BAK 4 kali, volume urin 1,50ml dan Potensi daya diuretic 0%. Kesimpulan : Potensi daya diuretic action yang paling tinggi dan efektif adalah kelompok III (dosis ekstrak daun seledri dosis 500mg) sebesar 90% karena memiliki efek frekuensi Buang air kecil (BAK) 6 kali dan volume urine 2,85 ml dibandingkan dengan kelompok lain. Hypertension is a disease of increasing blood pressure more than 140 mmHg. Hypertension is a major health problem in the world and the number of sufferers is increasing from year to year. Along with the increasing prevalence of hypertension in Indonesia and the many factors that influence the selection of synthetic antihypertensive drugs, it is demanded to continue to develop drugs derived from nature. Celery (Apium graveolens) has been known to have antihypertensive activity in the presence of apigenin which acts as a calcium antagonist so that it has a vasodilating or vasorelaxation effect. Objective: To determine the effective dose level of celery leaf extract as a hypertension drug. Methods: Experimental research post test only control group design. Results: Group I (Extract dose 300mg) had urinary frequency 4 times, urine volume 1.80ml and diuretic power potential of 20%, Group II (extract dose 400mg) had urinary frequency 5 times, urine volume 2.50ml and diuretic power potential 67 %, Group III (Extract dose of 500 mg) has a urinary frequency of 6 times, urine volume is 2.85 ml and diuretic power potential of 90%, Group IV (Furosemide) has a urinary frequency of 8 times, urine volume is 2.80 ml and potential diuretic power is 87%, Group V (Aquades) had urinary frequency 4 times, urine volume 1.50 ml and diuretic potential of 0%. Conclusion: The highest and most effective potential for diuretic action is group III (500mg dose of celery leaf extract) by 90% because it has an effect of 6 times urination frequency and 2.85 ml urine volume compared to other groups.
PENGARUH STABILITAS FISIK KRIM EKSTRAK DAUN KELOR (Moringa oleifera, Lamk.) TERHADAP VARIASI VASELIN ALBUM SEBAGAI OABAT JERAWAT joko santoso; Lanny Triana; Rr. Sri Wulandari; Ersta Zusvita; Dheny Rohmatika; Agnes Prameswari; Rolando Rahardjo
Jurnal Kesehatan Kusuma Husada Vol. 11 No. 2, Juli 2020
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.924 KB) | DOI: 10.34035/jk.v11i2.834

Abstract

Daun kelor (Moringa oleifera Lamk.) mengandung flavonoid dan tannin berfungsi sebagai tanaman obat yang berkhasiat untuk mengobati jerawat. Sekarang ini daun kelor (Moringa oleifera Lamk.) digunakan oleh masyarakat dengan cara dibuat serbuk untuk masker wajah sebagai obat jerawat, dengan cara ini masih menggunakkan cara konvensional dan cara pembuatannya sangat tidak praktis. Tujuan : Mengetahui pengaruh variasi basis vaselin album terhadap uji stabilitas fisik krim ekstrak daun kelor (Moringa oleifera Lamk.). Metode : penelitian ini merupakan penelitian eksperimental dengan menggunakkan variabel independent dna variabel dependent. Penelitian ini meliputi ekstraksi maserasi . krim dibuat dalam 3 formula. Formula I dengan konsentrasi vaselin album 4 g dan formulasi II dengan konsentrasi 8 g dan formulasi III vaselin album 16 g. Krim yang telah dibuat kemudian dilakukan uji kontrol kualitas yang meliputi uji organoleptis, uji daya sebar, uji daya lekat, dan uji pH. Hasil : Menunjukkan bahwa bahwa formulasi krim ekstrak daun kelor yang paling memenuhi standar sifat fisik krim setelah dilakukan adalah Formula II dengan basis vaselin album 8 gram ditunjukkan dengan hasil organoleptis konsistensi lunak ,ditunjukkan dengan pH 6,5, daya sebar 6 cm, daya lekat 4”64 dibandingkan dengan Formula I dan III. Kesimpulan : Ekstrak daun kelor (Moringa oleifera Lamk.) dapat diformulasikan menjadi sediaan krim dengan konsentrasi basis vaselin album 8 gram yang stabil secara fisik. Moringa leaves (Moringa oleifera Lamk.) contain flavonoids and tannins that function as medicinal plants that are efficacious for treating acne. Currently, Moringa leaves (Moringa oleifera Lamk.) are used by the community by making powder for face masks as acne medicine, in this way still using conventional methods and the method of making it is very impractical. Objective : To determine the effect of variations in Vaseline album base on the physical stability test of Moringa leaf extract cream (Moringa oleifera Lamk.). Methods: this research is an experimental study using independent variables and dependent variables. This research includes maceration extraction. The cream is made in 3 formulas. Formula I with a concentration of 4 g vaseline album and formulation II with a concentration of 8 g and formulation III with 16 g of vaseline albumin. The cream that has been made is then subjected to quality control tests which include organoleptic tests, dispersibility tests, adhesion tests, and pH tests. Results: Indicates that the formulation of Moringa leaf extract cream that best meets the standards of the physical properties of the cream after it has been done is Formula II with a base of 8 gram vaseline album indicated by soft consistency organoleptic results, indicated by pH 6.5, spreadability 6 cm, adhesion 4 ”64 compared to Formula I and III. Conclusion : Moringa leaf extract (Moringa oleifera Lamk.) can be formulated into a cream preparation with a physically stable concentration of 8 gram Vaseline album base.
Aktivitas Tabir Surya Pada Formulasi GEL Mengandung Ekstrak Etanol Daun Kersen (Muntingia Calabura Linn) Secara In Vitro Sineiwa Ipo Higyeungsi; Evi Nurul Hidayati; Joko Santoso
Jurnal Medika Nusantara Vol. 1 No. 4 (2023): November : Jurnal Medika Nusantara,
Publisher : Stikes Kesdam IV/Diponegoro Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59680/medika.v1i4.615

Abstract

The prevalence of breast cancer in the city of Surakarta was the second highest cancer prevalence in the province of Central Java in 2013, namely 678 cases, while in the city of Semarang as the first place there were 832 cases and the city of Magelang as the third place there were 348 cases. Kersen leaves (Muntingia Calabura L) have a high total flavonoid and phenol content so they can be used as a basic ingredient for making sunscreen gel. The aim of this research was to determine the sunscreen activity of a gel formulation containing ethanol extract of cherry leaves (Muntingia calabura L), the effective dosage, and the good quality of the preparation. This type of research uses quantitative analytical experimental methods. Kersen leaf ethanol extract sunscreen gel was made using Carbopol 940 base. Three formulas were made with a Carbopol base concentration of 1% and varying doses of cherry leaf extract 4%, 6%, 9%. The total flavonoid content of cherry leaves was 21.55 mg QE/g. The result of physical characteristics of FI (pH 4,82 ; Viscosity 250 dpas ; Spreadability 6,05 cm ; Adhesion 3,57cm), FII (pH 5,41 Viscosity 330 dpas ; Spreadability 5,79 cm ; Adhesion 4,43 cm), FIII (pH 5,84 Viscosity 360 dpas ; Spreadability 5,21 cm ; Adhesion 4,64 cm) and FIV (pH 4,63 ; Viscosity 170 dpas ; Spreadability 6,14 cm ; Adhesion 4,88 cm). The SPF values ??produced at extract concentrations of 4% (FI), 6% (FII), 9% (FIII) were 17.02; 34.74, and 40.09. The highest SPF value is found in FIII, namely 40.09, which is included in the ultra protection category with a cherry leaf extract concentration of 9%.