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Journal : Jurnal Syntax Fusion : Jurnal Nasional Indonesia

Hubungan Variasi Genetik Gen FADS pada Suku Sasak Terhadap Angka Kecukupan Gizi Ridha Sasmitha Ajiningrum; Luh Gde Sri Adnyani; Andi Agung Riatmojo; Vira Eka Trie Sanggita; Siti Rahmah
Jurnal Syntax Fusion Vol 2 No 01 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : Rifa' Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i01.137

Abstract

One of the macronutrients needed by the human body is fat. Fatty acids are divided into two, namely saturated and unsaturated fatty acids. Based on the source of unsaturated fatty acids are divided into two, namely non-essential and essential. Essential fatty acids consist of omega-3 and omega-6 which are part of PUFAs. To determine the relationship of genetic variation of the FADS gene to the nutritional adequacy of long-chain polyunsaturated fatty acids (LC-PUFA) in children of the Sasak ethnic. Systematic reviews were carried out through scientific journals, government guidelines, online portals for journal publications such as Medscape, Google Scholar, PubMed, and Science Direct, with the keyword “Polyunsaturated Fatty Acid (PUFA)” There was a significant relationship between the FADS2 index (DHA: EPA ratio) and MDI score (r = 0.648, p < 0.059) in AG but not in GG genotype. Two genotype models were found, namely homozygous major allele (GG) of rs 174468 which was dominant and heterozygous allele (AG) of Sasak ethnicity. The levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in infants in the Sasak ethnic were found to be higher than infants in other areas. Sasak ethnic children get EPA and DHA from breast milk which contains a lot of DHA. Sources of omega-3 and 6 on the island of Lombok are sea fish, seaweed, and full-blooded shellfish.
Penurunan Fungsi Sistem Penghidu Pada Pasien Penyakit Parkinson: Epidemiologi dan Tatalaksananya Andi Agung Riatmojo
Jurnal Syntax Fusion Vol 2 No 01 (2022): Jurnal Syntax Fusion: Jurnal Nasional Indonesia
Publisher : Rifa' Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/fusion.v2i01.144

Abstract

Parkinson's disease in general is a disorder of the central nervous system which most of its manifestations are motor function disorders. However, today's non-motor symptoms are found as early manifestations of Parkinson's disease. To determine the relationship between Parkinson's disease and non-motor symptoms, namely loss of smell or anosmia. The writing of this article includes various sources originating from scientific journals on online portals of journal publications such as MedScape, Google Scholar, PubMed, and NCBI, with the keywords "olfactory disorders and Parkinson's disease". Loss of smell can be the first symptom of pathological abnormalities in the central nervous system (CNS). Several studies related to Parkinson's disease stated that almost all patients studied had atrophy of the olfactory bulb, causing the patient to experience loss of smell function (anosmia). The effect of decreasing the volume of the olfactory bulb and the effect of neurotransmitters are also believed to affect the olfactory dysfunction in patients with Parkinson's disease. Anosmia is the most common non-motor symptom in Parkinson's disease, and often precedes motor symptoms in Parkinson's disease. Olfactory training is a promising modality for the treatment of olfactory dysfunction and anosmia. The results of this systematic review and meta-analysis suggest that it may be an effective treatment for olfactory dysfunction due to various etiologies