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All Journal Journal of Pharmaceutical and Medicinal Sciences Jurnal farmasi UIN Alauddin Makassar Proceeding of Mulawarman Pharmaceuticals Conferences
Ermina Pakki
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Efektivitas Bahan Peningkat Penetrasi, Isopropil Miristat Dalam Krim Antioksidan Ekstrak Biji Kasumba Turate (Carthamus tinctorius L.) Ermina Pakki; Muzakkir Rewa; Nur Irma
Jurnal Farmasi dan Ilmu Pengobatan Vol 4 No 2 (2019)
Publisher : STIFA Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (299.683 KB) | DOI: 10.32814/jpms.v4i2.91

Abstract

The research concerning on the effectiveness of isopropyl myristate as a penetration enhancer agent against diffusion rate of antioxidant creams containing lyophilizates kasumba turate seed (Carthamus tinctorius L.) extract using Franz diffusion method had been done. This research aims to determine the optimum concentration of isopropyl myristate in kasumba turate antioxidant cream. Started with the sample preparation, the seeds of kasumba turate were extracted using infusion method, lyophilized and specified its total polyphenol. As regard the lyophilization process, the lyophilizates were formulated into W/O cream with varied concentration of isopropyl myristate at 1% (FII), 5% (FIII), 10% (FIV) w/w and used cream without isopropyl myristate as negative control. Physical stability of creams was evaluated both before and after stressed conditional storages and used Franz diffusion instrument to observe the penetration ability of creams. As the result, all creams are physically stable. Furthermore, FIII and FIV have good penetration manner, especially FIV using 10% isopropyl myristate as a penetration enhancer agent in lyophilizates kasumba turate cream has the greatest polyphenol flux and cumulative amount.
Formulasi dan Evaluasi Granul Gastroretentive Mukoadhesif Amoksisilin Hamsinah Hamsinah; Jufri Jufri; Ermina Pakki
Jurnal Farmasi UIN Alauddin Makassar Vol 4 No 3 (2016): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v4i3.2228

Abstract

Amoxicillin is a semisynthetic antibiotic, belonging to the β-Lactam family, which is effective for bacterial infection treatment, especially for Helicobacter pylori infection. In this research, Amoxicillin was formulated as mucoadhesive granules dosage form to improve their effectivenesses by increasing the residence time of dosage form in the stomach. Mucoadhesive granules were prepared by wet granulation method in ten formulas using HidroxypropylMethyl cellulose, Methyl cellulose and Ethyl cellulose as mucoadhesive polymers. Granules were evaluated for moisture content, flow rate, angle of repose, density, mucoadhesive strength with wash off test, and dissolution.The results of this researchshowed that formula IB with 50% HPMC has best mucoadhesive strength with percentage of mucoadhesion 20% in 90 minutes of wash off test, and also formula IB is slowest formula in releasing of drug, with percentage of drug released is 55,76% in 15 minutes and 104,01% in 180 minutes.
Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Batang Banyuru (Pterospermum celebiqum Miq.) Dengan Variasi Phytocream® Asnah Marzuki; Ermina Pakki
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 5 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (589.762 KB) | DOI: 10.25026/mpc.v5i1.220

Abstract

Telah dilakukan penelitian Stabilitas Fisik Sediaan Krim Ekstrak Etanol Kulit Batang Banyuru (Pterospermum Celebiqum Miq.) Dengan Variasi Phytocream® Penelitian ini mengenai pengaruh emulgator phytocream® terhadap kestabilan fisik sediaan krim dari ekstrak etanol kulit batang banyuru (Pterospermum celebiqum Miq.). Dengan tujuan penelitian, untuk mendapatkan suatu sediaan dengan formula krim yang stabil, menggunakan emulgator phytocream® tipe M/A dari ekstrak etanol kulit batang banyuru. Ekstrak etanol kulit batang banyuru diperoleh dari hasil maserasi dengan etanol 96%. Di rotavaporasi dan liofilisasi untuk mendapatkan ekstrak kering. Ekstrak etanol kulit batang banyuru diformulasi dalam sediaan krim dalam variasi konsentrasi emulgator phytocream® 5, 7, dan 9 %. Evaluasi kestabilan fisik krim meliputi uji organoleptis, kriming, viskositas, pH dan pengukuran tetes terdispersi serta inversi fase sebelum dan setelah kondisi penyimpanan dipercepat selama 12 jam pada suhu 5°C dan 35°C. Pengamatan menunjukkan tidak ada perubahan secara organoleptis, warna dan bau pada tiga formula krim. Data penelitian menunjukkan secara signifikan tidak terjadi adanya kriming, inversi fase, perubahan viskositas, pH, dan ukuran fase terdispersi. Hasil penelitian pada tiga formula krim tipe M/A dengan variasi konsentrasi emulgator phytocream® adalah stabil secara fisik.
Co-Authors Asnah Marzuki Hamsinah Hamsinah Jufri Jufri Muzakkir Rewa Nur Irma