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All Journal Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Aldy S. Rambe
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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NEUTROPHIL-LYMPHOCYTE RATIO AND HIGH SENSITIVITY C-REACTIVE PROTEIN AS ISCHEMIC STROKE OUTCOME PREDICTOR Tissi Liskawini Putri; Ratna Akbari Ganie; Aldy S. Rambe
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 23, No 3 (2017)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v23i3.1201

Abstract

Proses inflamasi merupakan perjalanan penyakit dari strok iskemik akut, yang melibatkan penumpukan mediator inflamasi daninfiltrasi leukosit. Nilai Rasio Neutrofil-Limfosit (RNL) di beberapa penelitian dapat digunakan untuk meramalkan strok akibat iskemikakut yang caranya mudah dilakukan. High sensitivity C Reactive Protein (hs-CRP) merupakan reaktan tahap akut yang kadarnyameningkat di strok iskemik. Oleh karena itu bermanfaat sebagai petanda peramal hal terkait. Penelitian ini bertujuan untuk mengetahuiperbedaan nilai antara RNL dan hs-CRP dalam meramalkan hasilan pasien strok iskemik akut. Metode penelitian analitik observasionaldengan rancangan kohort prospektif. Hasil dinilai dengan modified Rankin Scale (mRS) (1–2=baik; 3–6=buruk) dan Barthel Index (BI)(0–20=ketergantungan jumlah keseluruhan, 21-60=berat; 1–90=sedang; 91–99=ringan dan 100=normal). Dari 43 sampel, didapatkanlaki-laki 24 orang (55,8%) dan perempuan 19 orang (44,2%) dengan rerata usia 57,12 ± 9,8 tahun. hubungan positif didapatkansedang dan bermakna antara RNL dengan hasilan mRS dan BI pasien strok iskemik akut (r=0,585; p=0,001 dan r=0,564; p=0,001).Hubungan positif didapatkan kuat dan bermakna antara hs-CRP dan hasilan mRS (r=0,614; p=0,001) serta didapatkan hubunganpositif dengan kekuatan sangat kuat dan bermakna antara hs-CRP dan hasilan n BI pasien strok iskemik akut (r=0,881; p=0,001).Dengan membandingkan ketepatan kedua data didapatkan RNL 86% dan hs-CRP 88% (p=0,6554). Perbedaan tidak bermakna terdapatantara nilai RNL dan hs-CRP sebagai peramal hasilan pasien strok iskemik akut.
Perbandingan akurasi diagnostik antara general practitioner assessment of cognition dan memory impairment screen terhadap mini-cog untuk screening poststroke dementia Annisa Ismira; Aldy S. Rambe; Fasihah Irfani Fitri
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 3 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background : Poststroke dementia is a common type of dementia which diagnosed at least 3 months after stroke. Early detection may relate to a better quality of life of the patients. GPCOG and MIS were proven to be the best instruments to use in screening of postsstroke dementia with high sensitivity and specifity.Objective : The aim of this study was to compare the diagnostic accuracy of General Practitioner Assessment of Cognitions and Memory Impairment Scale to Mini-Cog in screening of poststroke.Method : A cross sectional study of 66 subjects who came to Haji Adam Malik General Hospital with thew history of stroke at least three months before. All the subjects were assessed with Mini-Cog, GPCOG and MIS.Result : Disgnostic analysis of GPCOG in screening of poststroke dementia showed sensitivity 85%; specificity 68^; PPV 74%; NPV 81%; and accuracy 77%. And the diagnostic analiysis of MIS showed sensitivity 97%; speccificity 37%; PPV 62%; NPV 92%; and accuracy 68%.Conclusion : The GPCOG was better in screening poststroke dementia than the MIS with an insignificant difference of accuracy between GPCOG and MIS in screening of poststroke dementia (p=0.94)Keywords : Mini-Cog; GP-COG; MIS; Poststroke Deementia.
Co-Authors Annisa Ismira Fasihah Irfani Fitri Ratna Akbari Ganie Tissi Liskawini Putri