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All Journal Jurnal Penelitian Kesehatan Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Analis Farmasi Borneo Journal Of Pharmascientech Medfarm: Jurnal Farmasi dan Kesehatan Natural Sciences Engineering and Technology Journal JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT JAF (Jurnal Analis Farmasi) Medical Sains : Jurnal Ilmiah Kefarmasian Journal Borneo Jurnal Ilmiah Farmasi Akademi Farmasi Jember Hippocampus: Jurnal Pengabdian Kepada Masyarakat Serulingmas Health Journal (SHJ) Indonesian Journal of Pharmaceutical Research

Iswandi Iswandi

Faculty Of Pharmacy, Setia Budi University

Author-ID : 3552698

Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Library & Information Science Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Veterinary Other

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Aktivitas Antijamur Fraksi n-Heksana, Etil Asetat, dan Air dari Ekstrak Metanolik Daun Bunga Pukul Empat (Mirabilis jalapa L.) terhadap Pityrosporum ovale ATCCÂ® 3179 Agnes Christina Budiwati; Gunawan Pamudji Widodo; Iswandi Iswandi
Jurnal Farmasi Indonesia Vol 11 No 1 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Leaves of Mirabilis jalapa L. can inhibit the growth of Staphylococcus aureus and Aspergillus sp. The study aimed to determine the antifungal activity of n-hexane, ethyl acetate, and water fractions from the methanolic extract of leaves of Mirabilis jalapa L. against Pityrosporum ovale fungi and to determine the most effective fraction in inhibiting the growth of Pityrosporum ovale. Antifungal activity assays using the diffusion method, in which the test solution of Mirabilis jalapa L. leaves made serial consentrations of 10%, 5%, 3% entered in wells that have been applied to SGA media fungal suspension test. The results was analyzed using two ways statistical analysis. The result showed that of n-hexane, ethyl acetate, and water fractions from methanolic extracts Mirabilis jalapa L. leaves have antifungal activity against Phytyrosporum ovale. Ethyl acetate fraction at a concentration of 10% had the highest antifungal activity was 25 mm.

Pengaruh Waktu Fermentasi Teh Kombucha terhadap Penurunan Kadar Glukosa Darah pada Tikus Putih Jantan Galur Wistar dengan Induksi Aloksan Nilam Kristianingtyas; Inaratul Rizkhy Hanifah; Iswandi Iswandi
Jurnal Farmasi Indonesia Vol 12 No 1 (2015): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Diabetes mellitus is a group of metabolism disorders which is characteristic by the blood glucosa levels. Kombucha tea is a fermented product of sweet tea due o activity of yeast and bacteria.The research was aimed to determine the influence of various kombucha fermentation time on the decrease of glucose level in white male rats wistar. The tested animal is were inducted with aloksan and arranged into groups. Each group consisted of 5 white male rats. Group I as negative control was treated by aquadest. Group II, III dan IV were treated by 5,5 ml of 4, 8 and 12 days-fermentation kombucha tea, respectively. Group V, as positive control was treated by glibenclamide at 0,09 mg/200 g BB. The treatments were conducted for two weeks. Each group was observed for glucose levels an the firstand second week. The results were analyzed using one way ANOVA. The result showed that tea kombucha is able to decreaseglucose levels and the 12 days fermented kombucha tea has ability to decrease glucose levels better than 4 and 8 days fermented tea kombucha.

Pembinaan Teknik Bercocok Tanam Hidroponik Tanaman Obat di Perumahan Josroyo Ika Purwidyaningrum; Iswandi Iswandi; Meta Kartika Untari
Journal of Dedicators Community Vol 4, No 2 (2020)
Publisher : Universitas Islam Nahdlatul Ulama Jepara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34001/jdc.v4i2.1056

The development of the Hydroponic Planting Technique for Medicinal Planting in the Central Java Josroyo Housing was carried out with the aim of improving the quality of health and the economy of the community. Pollution is a daily consumption for residents living in big cities and densely populated settlements. On free roads, motor vehicle fumes mixed with cigarette smoke are almost inevitable. Health research about cigarette smoke that causes lung cancer is not new and widely reported by researchers. Hydroponics is a method of planting that is positive for health. Consuming vegetables and medicinal plants hydroponics is better than conventional vegetables and free of pesticides so it is healthy. Vegetables and medicinal hydroponic drugs are fresher and tastier than similar products from the market or vegetable vendors. The durability of vegetables and hydroponic medicinal plants is recognized relatively longer than vegetables grown above ground. The advantages of hydroponic planting methods are saving land, saving water, without pesticides, free of weed disturbances, on-target nutrition as well as saving land and labor so as to answer the problem of planting in Josroyo housing

Development of a Simultaneous Sulfadiazine, Sulfamethoxazole, and Tetracycline Antibiotic Level Determination Method with High-Performance Liquid Chromatography Yanulia Handayani; Iswandi; Supriyadi
Natural Sciences Engineering and Technology Journal Vol. 3 No. 1 (2023): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v3i1.25

Sulfonamides and tetracyclines are a group of synthetic antibacterials that are widely used in veterinary practice for the treatment and prevention of infections in animals that can be consumed by humans. The purpose of this study was to determine the optimum conditions for High-Performance Liquid Chromatography for simultaneous analysis of sulfadiazine, sulfamethoxazole, and tetracycline and meet the validation requirements. The research method used is the HPLC method. The instruments used are Agilent 1220 Infinity II low-pressure dual-channel gradient valve, variable wavelength detector (VWD) BI detector, the column used is Agilent 5 TC-C18 (250 x 4.6 mm), motion phase A = acetic acid 0.08%: acetonitrile (9:1) and motion phase B = methanol with a flow rate gradient of 0.5 mL/minute and UV-VIS detector at wavelength 295 hm. The results showed that the method of determining the levels of sulfadiazine, sulfamethoxazole, and tetracycline met the requirements of selectivity, accuracy, precision, linearity, LOD, and LOQ and could be applied to fish samples. The accuracy parameter test obtained recovery results between 96.99%-103.16% at all sample concentration levels of 80%, 100%, and 120%. Testing the precision parameters showed that all sample concentrations were 100% repeated for 6 times replications, fulfilling the precision requirements, namely, the concentration of ≥10 ppm was < 7.3%. The linearity test showed that the correlation coefficient of sulfadiazine was 0.999, sulfamethoxazole was 0.999, and tetracycline was 0.998. LOD and LOQ values of sulfadiazine 1.15 ppm and 3.84 ppm, sulfamethoxazole LOD 2.51 ppm and LOQ 8.37 ppm, and tetracycline LOD 3.37 ppm and LOQ 11.22 ppm. Applications to fish samples were carried out by addition and obtained levels of 14.79 ppm sulfadiazine, 14.01 ppm sulfamethoxazole, and 45.05 ppm tetracycline.

PENGARUH SUHU TERHADAP PERURAIAN KADAR ASETOSAL PADA TABLET GENERIK DAN PATEN SECARA SPEKTROFOTOMETRI UV Iswandi Iswandi
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 11 No 1 (2022): MEDFARM: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v11i1.92

Acetosal has many properties or broad therapeutic effects, including analgesic, antipyretic, non-steroidal anti-inflammatory, antifibrinolysis, inhibition of prostaglandin biosynthesis, pain relief, and cardiovascular disorders. The purpose of this study was to determine the effect of storage temperature on acetosal content and acetosal decomposition in generic and patent tablets. Acetosal tablets were stored at 250C, 500C and 750C, then weighed 50.0 mg and dissolved with 5.0 mL of ethanol and aquabidestilata to 100.0 mL, then diluted and read with the maximum wavelength. The results were calculated as percent acetosal content and percent decomposition and were analyzed using the Two Way Anova statistical test. The levels of generic acetosal tablets at 250C, 500C and 750C respectively yielded 94.3% (± 0.64) ; 91.53% (±1.19) ; 81.43% (± 0.73). Acetosal levels in patent tablets at temperatures of 250C, 500C and 750C respectively yielded 96.06% (± 0.68) ; 92.74% (±0.53) ; 87.15% (± 0.67). Acetosal decomposition results in generic tablets at temperatures of 250C, 500C and 750C respectively yielded 5.07% (± 0.64) ; 8.47 %(± 1.19); 18.57% (± 0.73). The levels of acetosal decomposition products in patent tablets at temperatures of 250C, 500C and 750C respectively yielded 3.94% (± 0.68) ; 7,26 %(± 0,53) ; 12.85% (± 0.67). The results of the two-way ANOVA showed that there was a significant difference in the levels of acetosal and decomposition products between generic tablets and patented tablets which were affected by storage temperature.

Karakterisasi Cocrystal Glibenklamida Dengan Variasi Pelarut dan Uji Stabilitas Termal Anang Kuncoro Rachmad Setiawan; Iswandi Iswandi; Dian Marlina
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 7, No 3 (2022)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v7i3.59893

Glibenklamida termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yaitu kelarutannya rendah. Kelarutan dapat ditingkatkan dengan dengan mengubah glibenklamida menjadi bentuk cocrystal. Penelitian bertujuan mengetahui karakteristik kristal dan pengaruh termal terhadap cocrystal glibenklamida yang dibuat dengan variasi pelarut aceton, etanol dan pelarut acetonitril-aceton, dan untuk mengetahui peningkatan kelarutan cocrystal glibenklamida. Cofomer yang digunakan asam oksalat dalam perbandingan equivalensi molar 1:1 dibuat dengan metode solvent evaporasi, menggunakan variasi pelarut aceton (F1), etanol (F2) dan pelarut campuran acetonitril-aceton (F3). Karakteristik cocrystal menggunakan Scanning Electron Microscopy (SEM), X-ray diffraction (XRD), Fourier Transform Infrared (FTIR), Differential Thermal Analysis (DTA), Differential Scanning Calorimetry (DSC), Thermal Gravimetric Analysis (TGA) dan uji kelarutan. Hasil penelitian cocrystal yang dibuat dengan variasi pelarut aceton (F1), etanol (F2) dan pelarut campuran acetonitril-aceton (F3) pada difraktogram XRD memiliki intensitas kristalisasi sudut 2θ: (F1) 5230,55; (F2) 4115,12 dan (F3)3404,17. Hasil spektra FTIR cocrystal pada gugus NH (F1) 3398,72 cm-1 (F2) 3381,36 (F3) 3404,51, pada gugus C=O (F1)1641,42 cm-1; (F2) 1433,17 cm-1; (F3) 1437,64 cm-1. Analisis termal DTA menunjukan titik leleh pada suhu 141-169,90C. Nilai entalpi (ΔH) dari DSC glibenklamida murni -38,0044 J/g; (F1) -12,14874 J/g; (F2) -38,8612 J/g; (F3) -5,8400 J/g. Hasil uji kelarutan terjadi peningkatan pada F1 6,75-12,65%, F2 7,40-12,52% dan F3 5,46-10,75%. Kesimpulan dari penelitian ini, cocrystal glibenklamida yang dibuat dengan variasi pelarut F1, F2 dan F3 memiliki perbedaan karakteristik kristal dan karakteristik terhadap pengaruh termal, cocrystal yang dibuat dengan pelarut aceton mempunyai peningkatan kelarutan yang paling tinggi sebesar 12,65 % pada medium pelarut dapar pH 4,5.

Evaluasi Perbandingan Sistem Rantai Dingin Penyimpanan Vaksin Maelana Eka Dewi; Iswandi Iswandi; meta kartika
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16485

Vaccines are preparations of biological products that contain antigens or contain components of microorganisms that have been attenuated from genetic engineering. Defective vaccine quality can be caused by the time of the cold chain storage process that is not in procedure. This study aims to compare the vaccine cold chain system in the warehouse of the City Health Office and Salatiga City Health Center which is guided by the Indonesian Minister of Health Regulation Number 12 of 2017. This type of research uses a descriptive observational method. The data collected in the form of quantitative and qualitative. Collecting qualitative data obtained from interviews and observations. Qualitative data were obtained from vaccine storage data in 2021. The results of the study obtained that he cold chain compatibility system at the City Health Office and Salatiga City Health Center was in good category, with the percentage of the City Health Office 88.88%, Cebongan Health Center 77.77%, Mangunsari Health Center 70.37%, Kalicacing Health Center 85.18%, Tegalrejo Health Center 81.48%, Sidorejo Lor Health Center 81.48%, Sidorejo Kidul Health Center 77.77%. Supporting facilities for vaccine storage are in accordance with the guidelines of the Permenkes RI Nomor 12 tahun 2017, in good category. With the percentage of the City Health Office 99.64%, Cebongan Health Center 96.87%, Mangunsari Health Center 97.02%, Kalicacing Health Center 91.80%, Tegalrejo Health Center 94.11%, Sidorejo Lor Health Center 96.29%, Sidorejo Kidul Health Center 98,30%.

Evaluasi Penyaluran Vaksin Sesuai Standar CDOB (Cara Distribusi Obat yang Baik) Kintan Fahra Ningrum; Iswandi Iswandi; Meta Kartika Untari
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.15644

Vaccines are biological products made using germs and then weekened. According to existing studies, 75% of vaccines in Indonesia are exposed to freezing temperatures during the distribution process, as a result, vaccines cannot be used anymore. The City Health Office has responsibility for the distribution of vaccines, especially in health centers, which must be evenly distributed and given regularly at the right time. The purpose of this study is the distribution of cold chain vaccines from the City Health Office to Salatiga Health Centers using the 2020 CDOB regulatory guidelines. This study uses an observational method that has a descriptive nature and evaluation using data collection techniques by interviewing with pharmacists or vaccine managers. The data will be based on the analysis of the result of data collection using an interview sheet, and the results will be stated with a percentation. The results of the study indicate that the distribution guidelines for the rantai dingin vaccine distribution system from the Health Office to the Salatiga City Health Center using the 2020 CDOB have a good category with a percentage of 72,72% and 84,21%. Then, there was a discrepancy in the distribution carried out by the Health Service to the Salatiga City Health Center but no deviation occurred, the vaccine distributed was not damaged or expired. Factors that may occur due to discrepancies are the lack of Human Resources (HR) for vaccine managers and vaccine warehouses that have not been maximized.

POLA PENGGUNAAN ANTIBIOTIK PADA PASIEN PNEUMONIA RAWAT INAP DI RSUD dr. GONDO SUWARNO TAHUN 2021 Iswandi Iswandi
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 2 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v5i2.115

Pneumonia is an infection at the ends of the bronchioles and alveoli which causes acute inflammation of the lung parenchyma caused by various pathogens such as bacteria, fungi, viruses and parasites. Most are caused by bacteria. Inappropriate use of antibiotics can lead to increased resistance, wasted costs and does not achieve optimal clinical benefits in the prevention and treatment of infections and bacterial resistance to drugs. The purpose of this study was to determine the suitability of the use of antibiotics according to therapy with the American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA) guidelines. This research method is a type of descriptive non-experimental research with a retrospective approach using cross sectional. Data collection according to the prescription of inpatients at dr. Gondo Suwarno who received antibiotics. Then grouped by type of antibiotic, dose, class, and duration of antibiotic administration. The number of samples is 100. Then the data is adjusted between therapy and guidelines. Based on the results of the study, it was found that there were more male patients. The most widely used dosage form is injection. The most common class of antibiotics is the cephalosporin group. In CAP pneumonia, the number of patients was 46 with the accuracy of the type of drug levofloxacin as many as 12 (26.08%). In HAP pneumonia, the number of patients was 54, with the accuracy of the type of antibiotic levofloxacin in 16 (29.62%). The accuracy of the type of ceftriaxone drug was 22 (40.74%)

Analisis Metampiron, Vitamin B1, B6, dan B12 secara Simultan menggunakan Kromatografi Cair Kinerja Tinggi Kolom Zic-HILIC Moh. Rivaldi Mappa; Iswandi Iswandi; Supriyadi Supriyadi
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 13 (2022): Nomor Khusus Desember 2022
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf.v13i0.2471

Determination of dosage levels needs to be done to maintain the quality of the preparation itself, so that the analytical method becomes an important part in examining pharmaceutical formulations in terms of quality control and safety. Therefore, it is necessary to study the determination of the levels of methampyrone, vitamins B1, B6, and B12 in multicomponent drugs simultaneously using Zic-HILIC column high performance liquid chromatography (HPLC). This literature review involved national and international research articles related to the analysis of methampyrone, vitamins B1, B6, and B12 in multicomponent drugs using the Zic-HILIC column HPLC method. Literature was obtained from several Elsevier, National Center for Biotechnology Information (NCBI), and Google Scholar. Based on the results of the literature study, it can be seen that the conditions of high performance liquid chromatography using a Zic-HILIC column which includes the composition of the mobile phase, the velocity of the mobile phase, the type of buffer, the pH of the mobile phase, the concentration of the buffer and the type of organic solvent affect the analysis process of methampyrone, vitamins B1, B6, and B12 simultaneously based on chromatographic parameters namely retention time, selectivity, retention factor, resolution, tailings factor, and the number of theoretical plates. The wavelengths that can be used to detect drug and vitamin mixtures are 272 and 275 nm. The solvent composition that can be used is a mixture of water, acetonitrile and buffer. The best speed of the mobile phase in the analysis process is 0.8 mL/minute. The types of buffers that can be used are ammonium formate, ammonium acetate, sodium dihydrogen phosphate and sodium sulfite with a buffer concentration of 10 mM and a pH of the mobile phase ranging from 3-6.Keywords: high performance liquid chromatography; Zic-HILIC; methampyron; vitamin; multicomponent ABSTRAK Penetapan kadar sediaan perlu dilakukan untuk menjaga mutu dari sediaan itu sendiri, sehingga metode analisis menjadi bagian penting dalam pemeriksaan formulasi sediaan farmasi dalam hal kontrol kualitas dan keamanannya. Maka diperlukan kajian penetapan kadar metampiron, vitamin B1, B6, dan B12 dalam obat multikomponen secara simultan menggunakan kromatografi cair kinerja tinggi (KCKT) kolom Zic-HILIC. Kajian literatur ini melibatkan artikel-artikel penelitian nasional maupun internasional, yang berhubungan dengan analisis metampiron, vitamin B1, B6, dan B12 dalam obat multikomponen menggunakan metode KCKT kolom Zic-HILIC.Literatur diperoleh dari beberapa Elsevier, National Center for Biotechnology Information (NCBI), dan Google Scholar. Berdasarkan hasil studi literatur dapat diketahui bahwa kondisi kromatografi cair kinerja tinggi menggunakan kolom Zic-HILIC yang meliputi komposisi fase gerak, kecepatan fase gerak, jenis buffer, pH fase gerak, konsentrasi buffer dan jenis pelarut organik mempengaruhi proses analisis metampiron, vitamin B1, B6, dan B12 secara simultan berdasarkan parameter kromatografi yakni waktu retensi, selektivitas, faktor retensi, resolusi, faktor tailing, dan jumlah lempeng teori. Panjang gelombang yang dapat digunakan untuk mendeteksi campuran obat dan vitamin adalah 272 dan 275 nm. Komposisi pelarut yang dapat digunakan adalah campuran air, asetonitril dan buffer. Kecepatan fase gerak pada proses analisis yang paling baik adalah 0,8 mL/menit. Jenis buffer yang dapat digunakan adalah amonium format, amonium asetat, natrium dihidrogen fosfat dan natrium sulfit dengan konsentrasi buffer 10 mM serta pH fase gerak berkisar antara 3-6.Kata kunci: kromatografi cair kinerja tinggi; Zic-HILIC; metampiron; vitamin; multikomponen

Co-Authors Agnes Christina Budiwati Anang Kuncoro Rachmad Setiawan Anita Nilawati Asmiyenti Djaliasrin Djalil Bangkit Riska Permata Cut Bidara Panita Umar Dian Marlina Endang Sri Rejeki Eva Widhia Saprini Sipa Fatmawati Fatmawati Fitra Indah Wiratantri Gunawan Pamudji Widodo Ika Purwidyaningrum Inaratul Rizkhy Hanifah Jena Hayu Widyasti Khusnul Hotimah Kintan Fahra Ningrum Kristanti Kristanti M. Aisy Akbar Firdaus Firdaus Maelana Eka Dewi meta kartika Meta Kartika Untari Meta Kartika Untari Meta Kartika Untari Moh. Rivaldi Mappa Nilam Kristianingtyas Nur Anggreini Dwi Sasangka PURWIDYANINGRUM, IKA Safira Prasita Dewanti Sri Devi Rahma Suherman Sumaryana Sumaryana Supriyadi Supriyadi Supriyadi TN Saifullah Tri Nur Azizah Yanulia Handayani

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