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All Journal Jurnal Farmasi Indonesia Jurnal Inovasi Farmasi Indonesia
Prayoga Fery Yuniarto
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Optimasi Formula Gel Buah Apel Hijau (Pyrus malus L.) sebagai Antioksidan dengan Kombinasi Basis Carbopol 940 dan Gliserin secara Simplex Lattice Design Prayoga Fery Yuniarto; Endang Sri Rejeki; Dewi Ekowati
Jurnal Farmasi Indonesia Vol 11 No 2 (2014): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1299.007 KB) | DOI: 10.31001/jfi.v11i2.64

Abstract

Apple is suspected has an antioxidant. The use of apple fruit directly considered less practical, so that it made the gel preparations. This research was aimed to optimation by Simplex Lattice Design method to get the most optimum formula gel of apple fruit as antioxidant gel. The apple fruit was macerated. The apple fruit gel use carbopol 940 (C) and glycerin (G) with three formula, F1 (100%C), F2 (50%C: 50%G), dan F3 (100%G). Optimation gel was done based on viscosity, adhesion, and dispersive power by Simplex Lattice Design method with design- expert 8.0.6.1 program. The optimum gel was analyzed the antioxidant activity by DPPH method by probit analysis for calculate IC50 value and vitamin C was used as control. The study shown that optimum combination of carbopol 940 and gliserin as basis was carbopol 2.448 g and glycerin 2.552 g. The optimum gel of apple fruit had antioxidant activity (IC50 151,43 ppm). Storage time affected the viscosity of the gel which tends to decrease during the months of storage.
OPTIMASI CARBOPOL 940 DAN GLISERIN PADA GEL TANAMAN ANTING-ANTING (Acalypha indica L.) SEBAGAI ANTIOKSIDAN prayoga fery yuniarto
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol 2, No 1 (2020): Vol. 2 No. 1 Desember 2020
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v2i1.1252

Abstract

Acalypha indica L. is suspected has an antioxidant. The use of anting-anting directly considered less practical, so that it made the gel preparations. And then it use optimation by Simplex Lattice Design method so get the most optimum antioxidant gel. This research purpose for know the efficacy of apple optimation gel as an antioxidant. Maceration extract made of gel with components carbopol 940(A) and glycerin(B) so that get three formulas, F1 (100%A), F2 (50%A, 50%B), dan F3 (100%B) and then optimation by viscosity, adhesion, and dispersive power. Simplex Lattice Design method with use program design- expert 8.0.6.1. Research antioxidant activity of optimum gel by method of DPPH. Antioxidant activity calculated by λ maximum and operating time so that get IC50 values by probit analysis. Optimation mixture between carbopol 940 and gliserin as components is carbopol 1,18 and glycerin 3,82. The resulted of t-test of viscosity, adhesion, and dispersive power showed no significant difference between the predictions with actual experimental result. The result showed optimum gel of apple fruit has antioxidant activity amounted to 164,58 ppm.
Co-Authors Dewi Ekowati Endang Sri Rejeki