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All Journal Juke Journal Syifa Sciences and Clinical Research (JSSCR) JK Unila (Jurnal Kedokteran Universitas Lampung)
Muhammad Ricky Ramadhian
Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Bakteriological Quality Of Refill Drinking Water At Refill Drinking Water Depots In Bandar Lampung Ety Apriliana; M Ricky Ramadhian; Meta Gapila
JUKE Unila Vol 4, No 07 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (94.34 KB)

Abstract

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INHERITED VARIATIONS IN DRUGS EFFECT INDEPENDENT IN PHARMACOKINETIC: POLYMORPHISM IN PHASE II BIOTRANSFORMATION ENZYMES Muhammad Ricky Ramadhian
JUKE Unila Vol 4, No 8 (2014)
Publisher : Fakultas Kedokteran Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.959 KB)

Abstract

Phase II enzymes play an important role in the biotransformation of endogenous compounds and xenobiotics to more easily excretable forms as well as in the metabolic inactivation of pharmacologically active substances. The purpose of phase II biotransformation is to perform conjugating reactions. These include glucuronidation, sulfation, methylation, acetylation, glutathione, and amino acid conjugation. In general, the respective conjugates are more hydrophilic than the parent compounds. Polymorphism in Phase II drug metabolism enzymes may have role in diseases, cancer, and others. This review discuss brief about polymorphism in Phase II drug metabolism enzyme. [JuKe Unila 2014; 4(8):254-268]
AKTIVITAS DIURESIS Leucaena leucocephala.L PADA MENCIT JANTAN (Mus musculus) Muhammad Ricky Ramadhian; Khairil Pahmi; Muhammad Taupik
Journal Syifa Sciences and Clinical Research Vol 3, No 1 (2021): Volume 3 Edisi 1 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i1.9894

Abstract

Diuretics are compounds or drugs that can increase urine volume. This study focused on exploring the activity and concentration of ethanol extract of lamtoro leaves (Leucaenaleucocephala L.) as a diuretic in male house mice (Musmusculus) using experimental research. The method used was to observe the physical activity of urine produced for 120 minutes. Lamtoro leaves extraction was done by maceration using solvent ethanol, then phytochemical screening tests. The screening results stated positively contained alkaloids, flavonoids, terpenoids, and tannins. The animals used were 25 house mice, divided into 5 groups. Group 1 was given Na-CMC 1% w/v suspension, group 2 with furosemide suspension 0.0041% w/v, group 3 with 25% w/v lamtoro leaf ethanol extract, group 4, ethanol extract 50% w/l lamtoro leaf , and group 5 was ethanol extract 75% w/v of lamtoro leaves. Urine volume of the house mice was measured at 15, 30, 45, 60, 75, 90, 105, and 120 minutes.
The Effect of Telmisartan on Collagen Percentages by Picrosirius Staining in the Glomerular Renal Organ of 8% NaCl-Induced Rats Khairil Pahmi; M Sidratullah; M Ricky Ramadhian
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.6976

Abstract

Excessive salt consumption is one of the hypertension and kidney disease factors, while telmisartan is one of antihypertensive drugs used in the therapy. Telmisartan not only blocks angiotensin receptor which leads to the decrease of blood pressure, but also activates peroxisome proliferator activated receptor gamma (PPAR-γ) and inhibits transforming growth expression factor of beta-1 (TGFβ-1). Whether telmisartan decreases the kidney collagen volume fraction of excessive NaCl-induced Wistar rats are studied in this experiment. Twenty five male Wistars 2.5-3 months of age and 100-150 g BW rats were used in this research. They were grouped into 5, each consists of 5 rats. Group I (G I) as first negative control did not receive NaCl and telmisartan. G II as second negative control received NaCl but not telmisartan. G III, IV and V received NaCl and telmisartan 3, 6 and 12 mg/kg BW. The treatments were given every day within 8 weeks. At the day of 56 all rats were sacrificed by mean of neck dislocation and operated to take the kidney. The collagen was stained by picrosirius red staining. Data were expressed as mean ± standard deviation. They were analyzed by parametric test (analysis of variance-ANOVA and paired samples t-test) or nonparametric test (Kruskal-Wallis). A value of p0.05 was considered statistically significant. The results showed that intraglomerular and extraglomerular collagen volume fraction were lower in telmisartan-treated Wistar rats group than negative control group (0.05p0.05). In conclusion, intraglomerular and extraglomerular collagen volume fraction were lower in 8% sodium chloride-induced and telmisartan-treated male Wistar rats than the items of negative control group.
Uji Diagnostik Kecacingan antara Pemeriksaan Feses dan Pemeriksaan Kotoran Kuku pada Siswa SDN 1 Krawangsari Kecamatan Natar Lampung Selatan Betta Kurniawan; Muhammad Ricky Ramadhian; Nurul Sahana Rahmadhini
Jurnal Kedokteran Universitas Lampung Vol 2, No 1 (2018): JK UNILA
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jk unila.v2i1.1907

Abstract

Kecacingan terjadi diawali dengan tertelannya telur atau masuknya larva yang infektif ke dalam kulit. Beberapa faktor yang dapat mempengaruhi tertelannya telur cacing berkaitan dengan higinitas yaitu kuku yang panjang dan tidak terawat. Pemeriksaan kotoran kuku akan dibandingkan dengan pemeriksaan gold standard untuk mengetahui nilai sensitivitas pemeriksaan kotoran kuku. Penelitian ini bersifat analitik komparatif dengan pendekatan cross sectional. Subjek penelitian terdiri dari 58 siswa dengan mengambil sampel feses dan kotoran kuku. Pemeriksaan feses dilakukan dengan metode apung dan pemeriksaan kuku dilakukan dengan metode sedimentasi. Angka kejadian kecacingan menggunakan bahan pemeriksaan feses sebesar 56% dan angka kejadian kecacingan menggunakan bahan pemeriksaan kotoran kuku sebesar 24,1%. Berdasarkan uji Mc-nemar didapatkan nilai p sebesar 0,02 yang artinya ada perbedaan yang bermakna antara pemeriksaan kotoran kuku dan pemeriksaan feses. Nilai sensitivitas dan spesifisitas sebesar 18,2% dan 68%. Nilai duga positif sebesar 42,8% dan nilai duga negatif sebesar 43,1%. Hasil pemeriksaan kuku dengan pemeriksan feses secara statistik terdapat perbedaan. Nilai sensitivitas didapatkan rendah, sehingga pemeriksaan kotoran kuku tidak mampu disetarakan dengan pemeriksaan feses.Kata Kunci : Diagnosis, kecacingan, pemeriksaan feses, pemeriksaan kuku
Co-Authors Betta Kurniawan, Betta Ety Apriliana Khairil Pahmi Khairil Pahmi M Sidratullah Meta Gapila Muhammad Taupik Nurul Sahana Rahmadhini