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Correlation between specific rubella immunoglobulin G (Ig G) and response evoked brainstem audiometry examination on confirmed congenital rubella syndrome (CRS) patients Rianto, Bambang Udji Djoko; Pratomo, Akmaluddin Agung; Prasetyo, Ashadi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Congenital rubella syndrome (CRS) is a health problem that can cause deaf child. Itsdiagnosis is based on clinical manifestation, specific rubella Immunoglobulin M (IgM) andIgG examination. The aim of this study was to evaluate the correlation between the specificrubella IgG level and the brainstem evoked response audiometry wave V. This was across sectional study involving congenital rubella syndrome (CRS) child patients at Dr.Sardjito General Hospital, Yogyakarta from 2011 to December 2016. The inclusion criteriawere 1) aged less than 24 months; 2) wave V of brainstem evoked response audiometryexamination has been identified. The exclusion criteria were 1) the patient’s parents refusedto participate and 2) incomplete data. Based on α: 5%, β: 20% and coefficient correlationestimation 0.04, minimal sample size were 47 subjects. All of subjects was underwentspecific rubella IgG examination. Statistical analysis by using Spearman`s correlation test.Wave V at the level <25 dB were found in 2 patients (4.3%), 26-40 dB results in 3 (6.4%)patients, 41-60 dB in 1 (2.1%) patient, 61-80dB was found in 9 (19.1%) patients and > 81db in 32 (68.1%) patients. A significant positive linear correlation between IgG levels (4-400 IU/mL) and wave V of brainstem evoked response audiometry was reported (p<0.05;r = 0.432). In conclusion, there is a positive correlation between specific rubella IgG leveland brainstem evoked response audiometry test results.

Effect of tonsillectomy with or without adenoidectomy on formant sound frequency Rianto, Bambang Udji Djoko; Jenny, .; Indrasari, Sagung Rai
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACT Vocal tract resonance characteristics are reflected by formant frequencies which determined by the size and shape of the vocal tract. Tonsillectomy may cause changes in the structure of the oral cavity as a resonator in the speech process. The aim of this study is to determine the effect of tonsillectomy on formant sound frequency. This study used a pre-test and post-test only design experimental. The study underwent in the Otorhinolaryngology Department between August up to November 2012. Inclusion criteria were: 1) chronic tonsillitis, 2) tonsil size was T3-T4, 3) age up to 5 years. The exclusion criteria were craniofacial abnormality and neurological disorders. All patients performed a sound analysis by recording vowel / a /, / e /, / i /, / o /, and / u / in 1 day before and 4 weeks after surgery. The sample consisted of 24 (60%) women and 16 (40%) men. The T3-T3 tonsil size were 25 (62.5%) samples and the lowest than T3-T4/T4-T3 were 6 (15%) samples. Based on paired T test there was a statistically significant increase of all F1 vowels (p <0.05), except for / i / (p> 0,05) and decrease of F2 / e / and F3 / u / (p >0,05). Based on these results it can be concluded that tonsillectomy affects the F1 mean difference almost in all vowel except the vowels / i /, F2 & F3.

The difference of nasal mucosal cytology features in gas station workers compared to non-gas station workers Rianto, Bambang Udji Djoko; Kurniawan, Linggawati; Sudarman, Kartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 1 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The pollutants contained in an outdoor air environment for example gasoline vapors can cause epithelial inflammation, metaplasia, and dysplasia. This study aimed to determine the difference in cytological nasal mucosa between gas station workers and non-gas station workers. This research used a cross-sectional design. There were 80 samples with inclusion criteria: aged 20-50 years, worked more than 3 months, consisting of 40 gas station workers (exposed group) and 40 non-gas station workers (unexposed group) who did not use nasal drops in the last ten days. The exclusion criteria of both groups were: 1) patients with acute rhinitis, 2) had nasal trauma, 3) had nasal surgery, 4) consume alcohol, 5) history of allergic rhinitis, and 6) refused to participate in the study. All samples performed brushing at 1/3 anterior nose inferior turbinate and cytology examination. The statistical analyses used X2 tests. From the exposed group we found 18 (45%) with inflammation, 17 samples (42.5%) with metaplasia, and 9 samples (22.5%) with dysplasia, while in the unexposed group there were 10 (20.5%) with inflammation, 4 (10.0%) with metaplasia and 2 (5.0%) dysplasia. There were statistically significant differences in nasal mucosal cytology, particularly metaplasia (p: 0.001; RP: 6.65; 95% CI: 1.78-27.01) and dysplasia (p: 0.023; RP: 5.52; 95% CI: 1.22-32.10) between both group samples. It can be concluded that there are statistically significant differences involving metaplasia and dysplasia in nasal mucosa cytology features of gas station workers compared to non-gas station workers.

Pengaruh Asap Rokok Terhadap Histopatologi Koklea: Studi pada Tikus Putih (Rattus norvegicus) Bambang Udji Djoko Rianto
MEDIA MEDIKA INDONESIANA 2013:MMI VOLUME 47 ISSUE 1 YEAR 2013
Publisher : MEDIA MEDIKA INDONESIANA

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ABSTRACT The effect of cigarette smoke on histopathology of cochleaBackground: Clinical studies have suggested that cigarette smoking associate with hearing loss. Smoke exposure is a risk factor to endothelial disfunction and developing atherosclerosis. Cochlea is a auditory organ that is sensitive to hipoxia condition. Objective this study was to determine the effect of cigarette smoke exposure to histological cochlear integrity.Methods: This was post test only design experimental study, using twenty male rats (Rattus norvegicus) were divided into 2 groups. The control group (10 rats) was kept in room free from cigarette smoke, while the experimental group (10 rats) was exposed to tobacco smoke, two cigarette per 1 hour exposure, twice a day, every work day, for 6 months from July 2004-February 2005. The cochlea rats were examined in Patologi Anatomi Laboratory Gadjah Mada University for histopathological examination.Results: There was 1 rat died in each group, and 18 rats (9 control group and 9 experimental group) were still alive. Based on histopathological result, there were abnormality in 7 rats (77.7%) of experimental group while all of control group were normal. This difference is significant statistically with Relatif Risk (RR) was 3.5 (95% CI: 0.66-34.53). The histopathological abnormality were of congestion of capilare, vacuolar degeneration, foam cell and necrosis of hair cells.Conclusion: Tobacco smoke causes histopatological abnormality in cochlear integrity. The relatif risk (RR) of histopathological abnormality on experimental group was 3.5.Keywords: Tobacco smoke, cochlea, stria vascularis, hair cells ABSTRAKLatar belakang: Beberapa studi klinik membuktikan bahwa kebiasaan merokok berhubungan dengan penurunan pendengaran. Paparan asap rokok merupakan faktor risiko terhadap disfungsi endotel yang dapat berkembang menjadi aterosklerosis. Koklea merupakan organ pendengaran yang sensitif terhadap keadaan hipoksia. Penelitian ini membuktikan pengaruh paparan asap rokok terhadap integritas histologis koklea.Metode: Rancang penelitian eksperimental yang digunakan adalah post test only design, dengan sampel sebanyak 20 ekor tikus putih jantan (Rattus norvegicus) dibagi menjadi 2 kelompok. Kelompok kontrol (10 ekor) disimpan di dalam ruangan bebas asap rokok. Kelompok eksperimental (10 ekor) diberi pajanan asap rokok 2 batang rokok per pajanan selama 1 jam, 2 kali sehari, setiap hari kerja selama 6 bulan dari bulan Juli 2004-Februari 2005. Koklea tikus diperiksa secara histopatologi di Laboratorium Patologi Anatomi Fakulatas Kedokteran Hewan Universitas Gadjah Mada.Hasil: Dari seluruh sampel didapatkan pada masing-masing kelompok 1 sampel mati, sedangkan 18 ekor tikus yang berhasil hidup sampai akhir masa pajanan (masing-masing kelompok 9 ekor) terdapat kelainan histologi pada 7 (77,7%) ekor tikus kelompok pajanan dengan RR 3,5 (95% CI: 0,66-34,53). Perubahan histopatolgi yang terjadi berupa kongesti pembuluh darah, degenerasi vakuoler, foam cell dan nekrosis sel rambut getar.Simpulan: Asap rokok berpengaruh pada kerusakan integritas histologis koklea. Kerusakan koklea pada kelompok pajanan asap rokok lebih besar dibanding kelompok kontrol dengan risiko relatif/RR sebesar 3,5.

The Role of Hearing Aids use on Reading Ability in Deaf Students Bambang Udji Djoko Rianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 02 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Introduction: Reading is a very complex process, which includes the cognitive process, initialized by visual analysis and letter transformation into vocabulary form, word identification by letter sound mapping, correlating words and interpretation. Deafness causes difficulties in acquiring language information via hearing process thus inhibiting a successful conversation process. Hearing aids can amplify sound information to the auditory organs. Objective: To know the effect of hearing aids on deaf students. Methods: A historical cohort design was done. The reading ability of 35 deaf students with hearing aids who received early education were compared to those without hearing aids. The variables measured included age, age of school enrollment, length of studies, degree of deafness, sex, parental educational level. Results: Regression analysis showed that hearing aids plays a role to significantly increase reading ability statistically (p: 0.006; OR: 10.197; 95% CI: 1.939-53.628) compared to students without hearing aids, besides the length of studies variable (p: 0.002; OR: 38.250: 95% CI: 3.739-391.361). Conclusion: This study concluded that the use of hearing aids significantly play a role to increase reading ability in deaf students who receive early education. Key words: hearing aids - deaf student - reading ability.

Human papillomavirus (HPV) as the causal factor of tympanal cholesteatoma in malignant-type chronic suppurative otitis media Bambang Udji Djoko Rianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Tympanal cholesteatoma is an uncoordinated, uncontrolled hyperproliferative epidermic epithelial cells keratinized with aggressive, erosive and destructive development to the mucous membrane and the bone of external auditory canal and tympanic cavity. This process is invasive and may migrate to the surrounding tissue. Ethiopathogenesis of tympanic cholesteatoma is unknown. Histological examination shows that there are hyperproliferative development, papillomatous, koilocyte clusters and destruction of the bone. These abnormalities are characteristics of papillomavirus.Objective: To know the whether HPV-18 is the risk factor in the occurrence of tympanic cholesteatoma ini malignant-type chronic suupurative otitis media.Methods: A case-control study was conducted on 31 tympanal cholesteatoma specimens from malignanttype chronic suppurative otitis media as the case group, and 31 mucosal tympanic cavity specimens from benign-type chronic suppurative otitis media as the control group. For detecting Polymerase chain reaction (PCR) examination was used to detect DNA HPV-18, that performed in Parasitology laboratorium Faculty of Medicine, Gadjah Mada University.Results: Polymerase chain reaction (PCR) examination showed that there were 21 (67.7%) DNA HPV-18 positive specimens in the case group, while in the control group there were 5 (16.1 %) DNA HPV-18 positive specimens. This difference was statistically significant (p = 0.0001; Odds ratio: 1 0.92; 95 % confidence interval = 2.83-45.29). Immunohistochemistry examination was used to identify host immune response to HPV, by observing the interleukin-1 IIl-1) and interferon g IIFN g) expressions. Both Il-1 and IFN g cytokines were highly expressed in tympanic cholesteatoma samples, compared to both in the control group. The difference was statistically significant (p < 0.05, Odds ratio 14.29; 95% confidence interval: 3.64-60.5 and p< 0.05, Odds ratio:10.2; 95% confidence interval: 2.74-40.35, respectively). Conclusion: It can be concluded that HPV-18 DNA was iidentified, and was one of the multiple risk factors in the occurence of tympanic cholesteatoma in malignant-type chronic suppurative otitis media..Key words: tympanal cholesteatoma - human papillomavirus - malignant-type chronic suppurative otitis media

Non infectious risk factors in pediatric sensorineural hearing loss Bambang Udji Djoko Rianto; Bondan Herwindo; Ashadi a Prasetyo; Anggoro Eka Radity
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 4 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Pediatric sensorineural hearing loss can cause delay in speech and daily socialcommunication. The causative factors are infectious or non infecious. The role ofinfectious risk factors in pediatric sensorineral hearing loss has been proven. However,the role of non infectious factors has not been reported, yet. The aim of the study was toevaluate the role of non infectious factors in pediatric sensorineural hearing loss (SNHL).This was a case control study using data collected from outpatients and medical recordsin Dr. Sardjito General Hospital, Yogyakarta from June to December 2015. The inclusioncriteria of case group were children with SNHL and aged 0 – 5 years old, whereasthe inclusion criteria of control group was children with normal hearing and aged 0-5years old. The exclusion criteria were children with history of infectious risk factors andhead trauma. Hearing status were determined by Otoacoustic Emission Testing (OAE)and Brainstem Evoked Response Auditory (BERA), based on a= 5%, b = 20%; ORasumption = 3.0. Sixty two subjects were selected with 31 subjects in each group.Multivariate analysis showed that low birth weight (LBW) (p=0.018; OR=6.553; 95%CI=1.38 – 31.13) and asphyxia (p= 0.041; OR=6.448; 95% CI=1.077 – 38.595)were risk factors, while hyperbilirubinemia (p= 0.382; OR=2.46; 95% CI=0.365 –13.805) and gestation (p=0.876; OR=0.831; 95% CI=0.081 – 8.483) were not riskfactors for pediatric SNHL. In conclusion, LBW and asphyxia are risk factors for pediatricSNHL, whereas prematurity and hyperbilirubinemia are not risk factors.

Hearing treshold before and after middle ear surgery in chronic suppurative otitis media (CSOM) Bambang Udji Djoko Rianto*; . Suwardi; Edhie Samodra
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 2 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Hearing loss is a common symptom in chronic suppurative otitis media (CSOM),often cause social communication disturbance. Canal wall up tympanoplastyand canal wall down tympanoplasty are surgery procedures for managing thisdisease that no response to convensional treatment. These surgery proceduresshould consider to hearing function impact. The aim of this study was to evaluatethe difference hearing threshold between before and after middle ear surgeryon CSOM patients. It was an historical cohort study conducted from January2015 to December 2016 involving CSOM patients who underwent canal wall uptympanoplasty surgery and canal wall down tympanoplasty in The Otology Division,Departement of Ear, Nose, Throat, Head and Neck Health, Dr. Sardjito GeneralHospital, Yogyakarta. The inclusion criteria included basic data, diagnostics,surgery reports, and audiometry results before and 3 months postoperatively,while the exclusion criteria were not complete medical record data. Total of 64patients with CSOM were involved in this study consisting of 32 patients whounderwent canal wall up tympanoplasty and 32 patients who underwent canal walldown tympanoplasty. Significantly different in the increasing of hearing thresholdbetween before and after canal wall up tympanoplasty surgery compared to thecanal wall down tympanoplasty was observed (p = 0.021). In addition, surgicaltechnique was the main factor affecting postoperative hearing threshold in CSOMpatients (p < 0.05). In conclusion, the increasing of hearing threshold in CSOMpatients underwent canal wall up tympanoplasty surgery is better than those underwentcanal wall down tympanoplasty.

The role of thyroid stimulating hormone level as a predictive factor for advance stage thyroid carcinoma Bambang Udji Djoko Rianto; Anton Sony Wibowo; Camelia Herdini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 51, No 4 (2019)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Thyroid stimulating hormone (TSH) is a cancer growth stimulus factor that have effect on the progression of thyroid carcinoma, common neck head malignancy. This hormonelevel has diagnostic value and can assist in the diagnosis, staging and management of the thyroid carcinoma.This study aimed to investigatethe role of TSH level as a predictor of advance stage thyroid carcinoma. This was case-control study involvingthyroid enlargement subjects who underwent thyroidectomy at Dr. Sardjito General Hospital, Yogyakartafrom 2015 to 2017. Cancer staging examination using AJCC 2102and TSH levels examination were conducted before underwent thyroidectomy.The inclusion criteria for case group were advanced stage(stage III and IV), while for control group wereearly-stage of thyroid carcinoma (stage I and II). The exclusion criteria for both case and control groups were 1) suffering from thyroid hormone disorders requiring therapy before thyroidectomy, 2) receiving thyroid suppression therapy prior to thyroidectomy. Sixty-six post thyroidectomy patients were involved in this study. The patients were divided into case and control groups consisted of 33 patients in each group. Based on receiver operating characteristic curve, the cut of point 1.27 mIU/L for TSH was obtained with sensitivity of 72.7% and specificity of 78.8%. There was statistically significant difference TSH levelsbetween early stage thyroid carcinoma and late stage thyroid carcinoma(p = 0.001;OR: 9.9;95% CI: 3.19-30.15).It can be concluded that TSHlevels ≥ 1.27mIU/L as predictor of advance stage thyroid carcinoma.

The relationship between duration suffering diabetes mellitus and hearing threshold based on audiometric examination Bambang Udji Djoko Rianto; Heri Puryanto; Kartono Sudarman
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art7

Background: Chronic hyperglycemia is associated with a long term damage, dysfunction or failure of several organs, which is a degenerative disorder caused by persistent hyperglycemia. Complications also can cause interference with the threshold of hearing. These degenerative changes include atrophy of axons, demyelinization, and loss of nerve fibers.Objective: This study aimed to determine the relationship between long suffering diabetes mellitus and hearing thresholds based on its frequency. Methods: This study was a cross sectional design on patients with diabetes mellitus in the Internal Medicine Clinic and Otorhinolaryngology Department Dr. Sardjito General Hospital Yogyakarta from early November 2010 until the end of June 2011. Inclusion criterion were: 1) >50 years old 2) normal physical ENT examination, 3) all DM types, 4) Sensorineural (Perceptive) Hearing Loss, 5) Right and left ear gap audiogram less than 15dB, and 6) agreed to participate. Mean difference such as age and duration of DM were assessed by using independent t test and Mann Whitney test. Distribution of sex and educational level were assessed by using Chi square test and Fisher's Exact test. Correlation between duration suffering diabetes mellitus and hearing threshold was assessed by the Spearman and Pearson method. Results: Subjects participated in this research were 25 (41.7%) men and 35 (58.3%) women. Result of this study showed that there were correlation between long suffering DM and hearing thresholds at 2000Hz : (r=0.459, p=0.097), 4000Hz (r=0.4966, p=0.098), and 6000Hz (r=0.757, p=0.422), respectively.Conclusion: It is can be concluded that there is a positive correlation between long suffering DM and hearing threshold, especially after 6 years.

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